The magnetic resonance imaging contrast agent mangafodipir exerts antitumor activity via a previously described superoxide dismutase mimetic activity [1]

Cancer Research

Volumn 66, Issue 1, 2006, Pages 598-

  Karlsson, Jan Olof G ^a   Brurok, Heidi ^a   Towart, Rob ^a   Jynge, Per ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CONTRAST MEDIUM; MANGAFODIPIR; OXALIPLATIN; SUPEROXIDE DISMUTASE;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CELL KILLING; CELL MEMBRANE TRANSPORT; CELL PROLIFERATION; DRUG MECHANISM; ELECTRON SPIN RESONANCE; LETTER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SPIN TRAPPING;

ANTINEOPLASTIC AGENTS; BIOMIMETIC MATERIALS; CONTRAST MEDIA; EDETIC ACID; HYDROGEN PEROXIDE; PYRIDOXAL PHOSPHATE; SUPEROXIDE DISMUTASE;

EID: 31544444499     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2053     Document Type: Letter

References (5)

1. Laurent A, Nicco C, Chéreau C, et al. Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res 2005;65:948-56.
2. Brurok H, Ardenkjær-Larsen JH, Hansson G, et al. Manganese dipyridoxyl diphosphate: MRI contrast agent with antioxidative and cardioprotective properties? In vitro and ex vivo assessments. Biochem Biophys Res Commun 1999;254:768-72.
3. Karlsson JOG, Brurok H, Eriksen M, et al. Cardioprotective effects of the magnetic resonance imaging agent manganese dipyridoxyl diphosphate and its metabolite manganese dipyridoxyl ethyldiamine upon reperfusion of the ischemic porcine myocardium. Acta Radiol 2001;42:540-7.
4. Bedda S, Laurent A, Conti F, et al. Manafodipir prevents liver injury induced by acetaminophen in the mouse. J Hepatol 2003;39:765-72.
5. Kensler TW, Bush DM, Kozumbo WJ. Inhibition of tumour promotion by a biomimetic SOD. Science 1983;221:75-81.