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Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 831, Issue 1-2, 2006, Pages 147-155

Quantitative determination of zebularine (NSC 309132), a DNA methyltransferase inhibitor, and three metabolites in murine plasma by high-performance liquid chromatography coupled with on-line radioactivity detection

(5) Beumer, Jan H a Joseph, Erin a Egorin, Merrill J a,b Covey, Joseph M c Eiseman, Julie L a,b

a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE (United States)

b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE (United States)

c NATIONAL CANCER INSTITUTE (United States)

Author keywords

DNA methyltransferase inhibitor; Metabolism; Murine; Radioactivity; Zebularine

Indexed keywords

ENZYMES; HYDROPHILICITY; LIQUID CHROMATOGRAPHY; METABOLISM; METABOLITES; PLASMAS; RADIOACTIVITY;

DNA METHYLTRANSFERASE INHIBITOR; DNA METHYLTRANSFERASES; MURINE; ZEBULARINE;

DNA;

DIHYDROURACIL; DNA METHYLTRANSFERASE INHIBITOR; DRUG METABOLITE; NSC 309132; UNCLASSIFIED DRUG; URACIL; URIDINE; ZEBULARINE; ZIDOVUDINE;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG METABOLISM; FOOD AND DRUG ADMINISTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; ONLINE ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIATION DETECTION;

ANIMALS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTIDINE; DNA MODIFICATION METHYLASES; DRUG STABILITY; MALE; MICE; MICE, INBRED STRAINS; ONLINE SYSTEMS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECIFIC PATHOGEN-FREE ORGANISMS; SPECTROPHOTOMETRY, ULTRAVIOLET; URACIL; URIDINE;

ANIMALIA; MURINAE;

EID: 31544441667 PISSN: 15700232 EISSN: None Source Type: Journal
DOI: 10.1016/j.jchromb.2005.11.048 Document Type: Article

Times cited : (13)

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