Parathyroid growth and regression in experimental uremia

Kidney International

Volumn 69, Issue 3, 2006, Pages 464-470

  Taniguchi, M ^a   Tokumoto, M ^a   Matsuo, D ^a   Tsuruya, K ^a   Hirakata, H ^a,b   Iida, M ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Calcium sensing receptor; Hyperplasia; Hypertrophy; p21; Vitamin D receptor

Indexed keywords

CALCITRIOL; CALCITRIOL RECEPTOR; CALCIUM SENSING RECEPTOR; KI 67 ANTIGEN; PHOSPHORUS; PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL SIZE; CONTROLLED STUDY; DIET; DISEASE COURSE; DRUG MECHANISM; HYPERPARATHYROIDISM; IMMUNOHISTOCHEMISTRY; MALE; NEPHRECTOMY; NICK END LABELING; NONHUMAN; ORGAN WEIGHT; PARATHYROID GLAND; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UREMIA;

ANIMALS; CALCITRIOL; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; GENE EXPRESSION REGULATION; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MALE; NEPHRECTOMY; ORGAN SIZE; PARATHYROID GLANDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCITRIOL; RECEPTORS, CALCIUM-SENSING; TIME FACTORS; UREMIA;

EID: 31544438582     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5000090     Document Type: Article

References (33)

1. Fukuda N, Tanaka H, Tominaga Y et al. Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest 1993; 92: 1436-1443.
2. Liu M, Lee MH, Cohen M et al. Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev 1996; 10: 142-153.
3. Tokumoto M, Tsuruya K, Fukuda K et al. Reduced p21, p27 and vitamin D receptor in the nodular hyperplasia in patients with advanced secondary hyperparathyroidism. Kidney Int 2002; 62: 1196-1207.
4. Brown AJ, Ritter CS, Finch JL et al. Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphate. Kidney Int 1999; 55: 1284-1292.
5. Naveh-Many T, Rahamimov R, Livni N et al. Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D. J Clin Invest 1995; 96: 1786-1793.
6. Ho C, Conner DA, Pollak MR et al. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet 1995; 11: 389-394.
7. Wada M, Furuya Y, Sakiyama J et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. J Clin Invest 1997; 100: 2977-2983.
8. WAF1 and transforming growth factor-α mediate dietary phosphate regulation of parathyroid cell growth. Kidney Int 2001; 59: 855-865.
9. 3 and 22-oxacalcitriol prevent the decrease in vitamin D receptor content in the parathyroid glands of uremic rats. Kidney Int 1996; 50: 34-39.
10. WAF1 and TGF-α mediate parathyroid growth arrest by vitamin D and high calcium. Kidney Int 2001; 60: 2109-2117.
11. Itin PH, Pittelkow MR, Kumar R. Effects of vitamin D metabolites on proliferation and differentiation of cultured human epidermal keratinocytes grown in serum-free or defined culture medium. Endocrinology 1994; 135: 1793-1798.
12. 3 upregulates the phosphatidylinositol signaling pathway in human keratinocytes by increasing phospholipase C levels. J Clin Invest 1995; 96: 602-609.
13. 2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes. J Clin Invest 1996; 97: 1577-1588.
14. 3 inhibits parathyroid cell proliferation in experimental uremia. Kidney Int 1989; 35: 1049-1056.
15. 3 in experimental renal hyperparathyroidism. Kidney Int 1993; 44: 1259-1265.
16. Fukagawa M, Kaname S, Igarashi T et al. Regulation of parathyroid hormone synthesis in chronic renal failure in rats. Kidney Int 1991; 39: 874-881.
17. Fukagawa M, Okazaki R, Takano K et al. Regression of parathyroid hyperplasia by calcitriol-pulse therapy in patients on long-term dialysis. N Engl J Med 1990; 323: 421-422.
18. Quarles LD, Yohay DA, Carroll BA et al. Prospective trial of pulse oral versus intravenous calcitriol treatment of hyperparathyroidism in ESRD. Kidney Int 1994; 45: 1710-1721.
19. Shiizaki K, Hatamura I, Negi S et al. Percutaneous maxacalcitol injection therapy regresses hyperplasia of parathyroid and induces apoptosis in uremia. Kidney Int 2003; 64: 992-1003.
20. Shiizaki K, Negi S, Hatamura I et al. Biochemical and cellular effects of direct maxacalcitol injection into parathyroid gland in uremic rats. J Am Soc Nephrol 2005; 16: 97-108.
21. Jara A, Gonzalez S, Felsenfeld AJ et al. Failure of high doses of calcitriol and hypercalcaemia to induce apoptosis in hyperplastic parathyroid glands of azotaemic rats. Nephrol Dial Transplant 2001; 16: 506-512.
22. 3 receptors in experimental uremia. Kidney Int 1987; 32: 350-353.
23. 2D receptors are decreased in parathyroid glands from chronically uremic dogs. Kidney Int 1989; 35: 19-23.
24. Shvil Y, Naveh-Many T, Barach P et al. Regulation of parathyroid cell gene expression in experimental uremia. J Am Soc Nephrol 1990; 1: 99-104.
25. Fukagawa M, Kitaoka M, Kurokawa K. Resistance of the parathyroid glands to vitamin D in renal failure: implications for medical management. Kidney Int 1997; 62(Suppl): S60-S64.
26. Ritter CS, Finch JL, Slatopolsky EA et al. Parathyroid hyperplasia in uremic rats precedes down-regulation of the calcium receptor. Kidney Int 2001; 60: 1737-1744.
27. Chattopadhyay N, Mithal A, Brown EM. The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism. Endocr Rev 1996; 17: 289-307.
28. Denda M, Finch J, Slatopolsky E. Phosphorus accelerates the development of parathyroid hyperplasia and secondary hyperparathyroidism in rats with renal failure. Am J Kidney Dis 1996; 28: 596-602.
29. Nagano N, Miyata S, Abe M et al. Sevelamer hydrochloride reverses parathyroid gland enlargement via regression of cell hypertrophy but not apoptosis in rats with chronic renal insufficiency. Nephrol Dial Transplant 2005; September 16 2005 [E-pub ahead of print].
30. Canaff L, Hendy GN. Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D. J Biol Chem 2002; 277: 30337-30350.
31. Slatopolsky E, Finch J, Denda M et al. Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro. J Clin Invest 1996; 97: 2534-2540.
32. 3 and 22-oxacalcitriol on phosphate and calcium metabolism. Kidney Int 1993; 43: 561-566.
33. Zhang P, Duchambon P, Gogusev J et al. Apoptosis in parathyroid hyperplasia of patients with primary or secondary uremic hyperparathyroidism. Kidney Int 2000; 57: 437-445.