Vitamin B12 deficiency and gastric histopathology in older patients

World Journal of Gastroenterology

Volumn 11, Issue 45, 2005, Pages 7078-7083

  Dholakia, K R ^a   Dharmarajan, T S ^a,c,d   Yadav, D ^a,c   Oiseth, S ^a,c   Norkus, E P ^a,c   Pitchumoni, C S ^b  

^a OUR LADY OF MERCY MEDICAL CENTER   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

^d NONE   (United States)

Author keywords

Gastric histopathology; Older adults; Vitamin B12 deficiency

Indexed keywords

ALBUMIN; CYANOCOBALAMIN; FERRITIN; INTRINSIC FACTOR; IRON; PROTEIN ANTIBODY;

ADULT; AGE DISTRIBUTION; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; ATROPHIC GASTRITIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYANOCOBALAMIN DEFICIENCY; FEMALE; FERRITIN BLOOD LEVEL; GASTRITIS; GASTROSCOPY; GERIATRIC PATIENT; HELICOBACTER INFECTION; HEMATOCRIT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFECTION RATE; INTESTINE MUCOSA; IRON DEFICIENCY; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; METAPLASIA; NUTRITIONAL STATUS; PATHOLOGIST; SEX DIFFERENCE; STOMACH BIOPSY; VITAMIN BLOOD LEVEL;

EID: 31544433398     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i45.7078     Document Type: Article

References (31)

1. Herbert V. Vitamin B12 - an overview. In: Herbert V. Vitamin B12 deficiency. London: Royal Society of Medicine Press, 1999: 1-81
2. Dharmarajan TS, Norkus EP. Approaches to vitamin B12 deficiency: Early treatment may prevent devastating complications. Postgrad Med 2001; 110: 99-106
3. Dharmarajan TS, Ugalino JT, Kanagala M, Pitchumoni S, Norkus EP. Vitamin B12 status in hospitalised elderly from nursing homes and the community. J Am Med Dir Assoc 2000;1: 21-24
4. Dharmarajan TS, Adiga GU, Norkus EP. Vitamin B12 deficiency: Recognizing subtle symptoms in older adults. Geriatrics 2003; 58: 30-38
5. Dharmarajan TS, Adiga GU, Pitchumoni S, Norkus EP. Vitamin B12 deficiency. In: Dharmarajan TS, Norman RA. Clinical Geriatrics, 1st ed., Boca Raton: CRC Press/Parthenon Publishing, 2003: 625-634
6. Dharmarajan TS, Yadav D, Norkus EP, Pitchumoni CS. Vitamin B12 deficiency in older adults: Upper endoscopic and fundic histopathologic findings in newly diagnosed patients. J Am Geriatrics Soc 2001; 49: S119
7. Pitchumoni S, Dharmarajan TS. Vitamin B12, the gastrointestinal system and aging. Pract Gastroenterol 2001; 25: 27-40
8. Toh B, van Driel IR, Gleeson PA. Pernicious Anemia. NEJM 1997; 337: 1441-1448
9. Pruthi RK, Tefferi A. Pernicious anemia revisited. Mayo Clin Proc 1994; 69: 144-1450
10. Weinstein WM. Gastritis and gastropathies. In: Feldman M, Scharschmidt BF, Sleisenger MH. Gastrointestinal and Liver disease, Pathophysiology, Diagnosis and Management. W. B. Saunders, 1993: 711-732
11. Pitchumoni CS, Kokkat AJ, Dharmarajan TS. The gastrointestinal system. In: Dharmarajan TS, Norman RA. Clinical Geriatrics, 1st ed., Boca Raton: CRC Press/Parthenon Publishing, 2003: 416-428
12. Boger WP, Wright LD, Strickland SC, Gylfe JS, Ciminera JL, Vitamin B12: Correlation of serum concentrations and age. Proc Soc Exp Biol Med 1955; 89: 375-378.
13. Chow BF, Wood R, Horonick A, Okuda K. Agewise variation of vitamin B12 serum levels. J Gerontol 1956; 11: 142-146
14. Green R, Kinsella LJ. Current concepts in the diagnosis of cobalamin deficiency. Neurology 1995; 45: 1435-1440
15. Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Ann Intern Med 1994; 120:211-215
16. Richter JE. Should patients receiving long-term gastric inhibition therapy be evaluated for vitamin B12 deficiency? Cleve Clin J Med 2000; 67: 785-787
17. Dharmarajan TS, Patel B, Norkus EP. Do acid lowering agents lower vitamin B12 status in the community elderly? J Am Coll Nutr 1999; 18: 546.
18. Lehy T, Roucayrol AM, Mignon M. Histomorphological characteristics of gastric mucosa in patients with Zollinger-Ellison syndrome or autoimmune gastric atrophy, role of gastrin and atrophying gastritis. Microsc Res Tech 2000; 48: 327-338
19. Strickland RG, Mackay IR. A reappraisal of the nature and significance of chronic atrophic gastritis. Am J Dig Dis 1973; 18: 426-440
20. Owen DA. The stomach. In: Sternberg SS. Diagnostic Surgical Pathology, 3rd ed., Philadelphia: Lippincott Williams and Wilkins, 1999: 1310-1327
21. Wyatt JI, Dixon MF. Chronic gastritis: a pathogenetic approach. J Pathol 1988; 154: 944-951
22. Fong TL, Dooley CP, Dehesa M. Helicobacter pylori infection in pernicious anemia: a prospective controlled study. Gastroenterology 1991; 100: 328-332
23. Kaye MD, Whorwell PJ, Wright R. Gastric mucosal lymphocyte subpopulations in pernicious anemia and in normal stomach. Clin Immunol Immunopathol 1983; 28: 431-440
24. Baur S, Fisher JM, Strickland RG, Taylor KB. Autoantibody containing cells in the gastric mucosa in pernicious anemia. Lancet 1968; 2: 887-894
25. Loffeld BC, Van Spreeuwel JP. The gastrointestinal tract in pernicious anemia. Dig Dis 1991; 9: 70-77
26. Serin E, Gumurdulu Y, Ozer B, Kayaselcuk F, Yilmaz U, Kocak R. Impact of Helicobacter pylori on the development of vitamin B12 deficiency in the absence of gastric atrophy. helicobacter 2002; 7: 337-341
27. Annibale B, Negrini R, Caruana P, Carvana p, Lahaier E, Grossi C, Bordi C, Delle Fave G. Two-thirds of atrophic body gastritis patients have evidence of Helicobacter pylori infection. Helicobacter 2001; 6: 225-233
28. Kaptan K, Beyan C, Ural AU, Cetin T, Avcu F. Helicobacter pylori - is it a novel causative agent in vitamin B12 deficiency? Arch Intern Med 2000; 160: 1349-1353
29. Carmel R, Aurangzeb I, Qian D. Associations of food-cobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis. Am J Gastroenterol 2001; 96: 63-70
30. Haruma K, Komoto K, Kawaguchi H, Okamoto S, Yoshihara M, Sumii K, Kajiyama G. Pernicious anemia and Helicobacter pylori infection in Japan: Evaluation in a country with a high prevalence of infection. Am J Gastroenterol 1995; 90: 1107-1110
31. Carmel R. Cobalamin, the stomach, and aging. Am J Clin Nutr 1997; 66: 750-759