Guarana consumption: A review of health benefits and risks

Alternative and Complementary Therapies

Volumn 11, Issue 4, 2005, Pages 212-213

  Ravi Subbiah, M T ^a,b  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b Biostart Company   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE DERIVATIVE; CAFFEINE; CARBOHYDRATE; CATECHIN; EPHEDRA SINICA EXTRACT; EPHEDRINE; METHOXYPHENYLPROPENE; METHYLXANTHINE; OLEIC ACID; PROCYANIDIN; RESIN; SESQUITERPENE; TANNIN; THEOBROMINE; THEOPHYLLINE; THROMBOXANE; TOLUENE DERIVATIVE; UNCLASSIFIED DRUG;

DIET SUPPLEMENTATION; HEALTH HAZARD; HEART ARRHYTHMIA; HEART DISEASE; HEART VENTRICLE EXTRASYSTOLE; HERBAL MEDICINE; HUMAN; HYPERTENSION; PAULLINIA; PAULLINIA CUPANA; PHYTOCHEMISTRY; REVIEW; RISK BENEFIT ANALYSIS; STROKE; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

EID: 31444452628     PISSN: 10762809     EISSN: None     Source Type: Journal    
DOI: 10.1089/act.2005.11.212     Document Type: Review

References (24)

1. Henman AR. Guarana (Paullinia cupana var. sorbilis): Ecological and social perspectives on an economic plant of the Central Amazon Basin. J Ethnopharmacol 1982;6:311-338.
2. Erickson HT, Correa MPF, Escobar JR. Guarana. Econ Botany 1984;38:273-286.
3. Belliardo F, Martelli A, Valle MG. HPLC determination of caffeine and theophylline in Paullinia cupana Kunth (guarana) and Cola spp. samples. Z Lebensm Unters Forsch 1985;180:398-401.
4. Bempong D, Houghton PJ, Steadman K. The caffeine content of guarana. J Pharm Pharmacol 1991;43(suppl):125. Proceedings of the British Pharmaceutical Conference, Merseyside, UK, September 10-13, 1991.
5. Bempong D, Houghton PJ. Dissolution and absorption of caffeine from guarana. J Pharm Pharmacol 1992;44:769-771.
6. Marx F. Analysis of guarana seeds: II. Studies on the composition of the tannin fraction. J Lebensm Unters Forsch 1990;190:429-431.
7. Benoni H, Dallakian P, Taraz K. Studies on the essential oil from guarana. Z Lebensm Unters Forsch 1996;203:95-98.
8. Avato P, Pesante MA, Fanizzi FP, Santos CA. Seed oil composition of Paullinia cupana var. sorbilis (Mart) Ducke. Lipids 2003;38:773-780.
9. Bydlowski SP, Yunker RL, Subbiah MTR. A novel property of aqueous guarana extract (Paullinia cupana): Inhibition of platelet aggregation. Braz J Med Biol Res 1988;21:535-538.
10. Bydlowski S, D'Amico EA, Chamone DA. An aqueous extract of guarana (Paullinia cupana) decreases platelet thromboxane synthesis. Braz J Med Biol Res 1991;124:421-424.
11. Hirsh J. Hyperactive platelets and complications of coronary artery disease. N Engl J Med 1989;316:1543-1544.
12. Subbiah MTR. Cardiovascular risk associated with estrogen replacement therapy: Some critical questions about the type of estrogen used in most clinical trials. Atherosclerosis 2004;173:373-374.
13. Kennedy DO, Haskell CF, Wesnes KA, Scholey AB. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: Comparison and interaction with Panax ginseng. Pharmacol Biochem Behav 2004;79:401-411.
14. Campos AR, Barros AI, Santos FA, Rao VS. Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats. Phytother Res 2003;17:1199-1202.
15. Fukumasu H, Silva TC, Avanzo JL, et al. Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guarana on mouse hepatocarcinogenesis. Cancer Lett, May 2005.
16. Mattei R, Dias RF, Espinola EB, et al. Guarana (Paullinia cupana): Toxic behaviour effects in laboratory animals and antioxidant activity in vitro. J Ethnopharmacol 1998;60:111-116.
17. Ray S, Phadke S, Patel C, et al. Short-term and long-term in vivo exposure to an ephedra- and caffeine-containing metabolic nutrition system does not induce cardiotoxicity in B6C3F1 mice. Arch Toxicol 2005; 79:330-340.
18. Nyska A, Murphy E, Foley JF, et.al. Acute hemorrhagic myocardial necrosis and sudden death of rat exposed to a combination of ephedra and caffeine. Toxicol Sci 2005;83:388-396.
19. Haller CA, Jacob P, Benowitz NL. Pharmacology of ephedra alkaloids and caffeine after single dosage dietary supplement use. Clin Pharmacol Ther 2002;71:421-432.
20. Baghkhani L, Jafari M. Cardiovascular adverse reactions associated with guarana: Is this a causal effect? J Herb Pharmacother 2002;2: 57-61.
21. Cannon ME, Cooke CT, McCarthy JS. Caffeine-induced cardiac arrhythmia: An unrecognized danger of health food products. Med J Aust 2001;174:520-521.
22. Spinella M. Herbal medicines and epilepsy: The potential for benefit and adverse effects. Epilepsy Behav 2001;2:524-532.
23. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. Am J Med Sci 2004;327:356-357.
24. Donadio V, Bonsi P, Zele I, et.al. Myoglobinuria after ingestion of guarana, ginkgo biloba and kava. Neurol Sci 2000;21:124.