New data on biological effects of chlorhexidine: Fe2+ induced lipid peroxidation and mitochondrial permeability transition

Toxicology Letters

Volumn 151, Issue 3, 2004, Pages 407-416

  Negrelo Newton, Ana Paula ^a   Cadena, Silvia Maria S C ^a   Merlin Rocha, Maria Eliane ^a   Skäre Carnieri, Eva Gunilla ^a   Martinelli De Oliveira, Maria Benigna ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Chlorhexidine; Lipid peroxidation; Mitochondrial permeability transition (MPT)

Indexed keywords

CHLORHEXIDINE; CYCLOSPORIN A; DITHIOTHREITOL; EGTAZIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CHEMICAL INTERACTION; CONTROLLED STUDY; IRON KINETICS; LIPID PEROXIDATION; MALE; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CALCIUM; CHLORHEXIDINE; FERRITINS; IRON; LIPID PEROXIDATION; MALE; MITOCHONDRIA; MITOCHONDRIAL SWELLING; PERMEABILITY; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 3142782441     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2004.02.013     Document Type: Article

References (43)

1. Addy M., Wade W., Goodfield S. Staining and antimicrobial properties in vitro of some chlorhexidine formulations. Clin. Prev. Dent. 12:1990;13-17
2. Babich H., Wurzburger B.J., Rubin Y.L., Sinensky M.C., Blau L. An in vitro study on the cytotoxicity of chlorhexidine digluconate to human gingival cells. Cell Biol. Toxicol. 11:1995;79-88
3. 2+-induced dysfunction of isolated rat liver mitochondria: doubts no more. Arch. Biochem. Biophys. 405:2002;252-264
4. Bernardi P. Mitochondrial transport of cations: channels, exchangers and permeability transition. Physiol. Rev. 79:1999;1127-1155
5. Bonine F.L. Effect of chlorhexidine rinse on the incidence of dry socket in impacted mandibular third molar extraction sites. Oral. Surg. Oral. Med. Oral. Pathol. 79:1995;154-157
6. Buege, J.A., Aust, S.D., 1978. Microssomal lipid peroxidation. In: Fleischer, S., Packer, L. (Eds.), Methods in Enzymology, vol. 52. Academic Press, San Diego, pp. 302-310.
7. Carbonera D., Azzone G.F. Permeability of inner mitochondrial membrane and oxidative stress. Biochim. Biophys. Acta. 943:1988;245-455
8. Christensen F., Bleeg H.S., Jensen J.E. The effect of chlorhexidine on some biochemical parameters of rat liver mitochondria. Acta Pharmacol. Toxicol. 36:1975;01-12
9. Christensen F., Jensen J.E. The effect of chlorhexidine on some biochemical parameters of rat liver microsomes. Acta Pharmacol. Toxicol. 35:1974;33-41
10. Ellingsen J.E., Rolla G., Eriksen H.M. Extrinsic dental stain caused by chlorhexidine and other denaturing agents. J. Clin. Periodontol. 9:1982;317-322
11. 2+ plus oxidants. J. Biol. Chem. 265:1990;19955-19960
12. Ferreira F.M.L., Madeira U.M.C., Moreno A.J. Interaction of 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene with mitochondrial oxidative phosphorylation. Biochem. Pharmacol. 53:1997;299-308
13. Gabler W.L., Bullock W.W., Creamer H.R. The influence of chlorhexidine on superoxide generation by induced human neutrophils. J. Periodontal Res. 22:1987;445-450
14. Gendron R., Grenier D., Sorsa T., Mayrand D. Inhibition of the activities of matriz metalloproteinases 2, 8 and 9 by chlorhexidine. Clin. Diagn. Lab. Immun. 6:1999;437-439
15. Greenstein G., Polson A. The role of local drug delivery in the management of periodontal diseases: a comprehensive review. J. Periodontol. 69:1998;507-520
16. Gunter T.E., Pfeiffer D.R. Mechanisms by which mitochondria transport calcium. Am. J. Physiol. 258:1990;755-786
17. Halestrap A.P., Kerr P.M., Javadov S., Woodfield K.Y. Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. Biochim. Biophys. Acta. 1366:1998;70-94
18. Halliwell, B., Gutteridge, J.M.C., 1999. Free Radicals in Biology and Medicine. Oxford University Press, New York.
19. He L., Lemasters J.J. Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function? FEBS Lett. 512:2002;1-7
20. Hidalgo E., Domingues C. Mechanisms underlying chlorhexidine-induced cytotoxicity. Toxicol. In Vitr. 15:2001;271-276
21. Jaminet F.R., Delattre L., Delporte J.P., Moes A. Influence de la temperature de sterilization et du pH sur la stabilité de la chlorhexidine en solution. Pharm. Acta Helvetiae. 45:1970;60-63
22. Knuuttila M., Söderling E. Effect of chlorhexidine on the release of lysosomal enzymes from cultured macrophages. Acta Odontol. Scand. 39:1981;285-289
23. Kowaltowski A., Vercesi A.E. Mitochondrial damage induced by conditions of oxidative stress. Free Radic. Biol. Med. 26:1999;463-471
24. Kroemer G. Mitochondrial control of apoptosis: an introduction. Biochem. Biophys. Res. Commun. 304:2003;433-435
25. Lafforgue C., Carret L., Falson F., Reverdy M.E., Freney J. Pericutaneous absorption of a chlorhexidine digluconate solution. Int. J. Pharm. 147:1997;243-246
26. Lambert P.M., Morris H.F., Ochi S. The influence of 0.12% chlorhexidine digluconate rinses on the incidence of infectious complications and implant success. J. Oral Maxillofac. Surg. 55(Suppl. 5):1997;25-30
27. Löe H., Schiott C.R. The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man. J. Periodontal Res. 5:1970;79-83
28. Lowry O.H., Rosebrough N.J., Farr A.C., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275
29. Lucarotti M.E., White H., Deas J., Silver I.A., Leaper D.J. Antiseptic toxicity to breast carcinoma in tissue culture: an adjuvant to conservation therapy? Ann. R. Coll. Surg. Engl. 72:1990;388-392
30. Moghadam B.K.H., Drisko C.L., Gier R.E. Chlorhexidine mouthwash-induced fixed drug eruption. Case report and review of the literature. Oral Surg. Oral Med. Oral Pathol. 71:1991;431-434
31. Oteiza P.I., Kleinman C.G., Demasi M., Bechara E.J.H. 5-Aminolevulinic acid induces iron release from ferritin. Arch. Biochem. Biophys. 316:1995;607-611
32. Penzo D., Tagliapietra C., Colonna R., Petronilli V., Bernardi P. Effects of fatty acids on mitochondria: implications for cell death. Biochem. Biophys. Acta. 1555:2002;160-165
33. Rocha M.E.M., Ferreira A.M.D.C., Bechara E.J.H. Roles of phosphate and an enoyl radical in ferritin iron mobilization by 5-aminolevulinic acid. Free Radic. Biol. Med. 29:2000;1272-1279
34. Sassa H., Kogure K., Takaishi Y., Terada H. Structural basis of potent antiperoxidation activity of the triterpene celastrol in mitochondria: effect of negative membrane surface charge on lipid peroxidation. Free Radic. Biol. Med. 17:1994;201-207
35. Sakura I.K., Stoyanovski D.A., Fujimoto Y., Cederbaum A.I. Mitochondrial permeability transition induced by 1-hydroxyethyl radical. Free Radic. Biol. Med. 28:2000;273-280
36. Sheen S., Banfield N., Addy M. The propensity of individual saliva to cause staining in vitro - a developmental method. J. Dent. 29:2001;99-102
37. 2 levels in gingival crevicular fluid. Eur. J. Oral Sci. 106:1998;571-575
38. Vladimirov Y.A., Olenev V.I., Suslova T.B., Cheremisina Z.P. Lipid peroxidation in mitochondrial membranes. Adv. Lipid Res. 17:1980;173-249
39. Voss D.O., Campello A.P., Bacila M. The respiratory chain and oxidative phosphorylation of rat brain mitochondria. Biochem. Biophys. Res. Commun. 4:1961;48-51
40. Wallace K.B., Starkov A. Mitochondrial target of drug toxicity. Ann. Rev. Pharmacol. Toxicol. 40:2000;353-388
41. Walter L., Nogueira V., Leverve X., Heintz M.P., Bernardi P., Fontaine E. Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through a common site. J. Biol. Chem. 275:2000;29521-29527
42. Warner R.R., Myers M.C., Burns J., Mitra S. Analytical electron microscopy of chlorhexidine-induced tooth stain in humans: direct evidence for metal-induced stain. J. Periodontal Res. 28:1993;255-265
43. Zoratti M., Szabò I. The mitochondrial permeability transition. Biochim. Biophys. Acta. 1241:1995;139-176