Lithium ion "cyclotron resonance" magnetic fields decrease seizure onset times in lithium-pilocarpine seized rats

International Journal of Neuroscience

Volumn 114, Issue 8, 2004, Pages 1035-1045

  McKay, B E ^a   Persinger, M A ^a  

^a LAURENTIAN UNIVERSITY   (Canada)

Author keywords

Cyclotron resonance; Epilepsy; Magnetic fields; Rats; Seizures

Indexed keywords

LITHIUM ION; PILOCARPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCULATION; CHOLINERGIC SYSTEM; CYCLOTRON; ELECTRICITY; MAGNETIC FIELD; MALE; MASS; NONHUMAN; PREDICTION; RAT; SEIZURE; STATISTICAL SIGNIFICANCE;

ANALYSIS OF VARIANCE; ANIMALS; CYCLOTRONS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTROMAGNETIC FIELDS; LITHIUM; LITHIUM CHLORIDE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PILOCARPINE; RATS; RATS, WISTAR; SEIZURES; TIME FACTORS;

EID: 3142778700     PISSN: 00207454     EISSN: None     Source Type: Journal    
DOI: 10.1080/00207450490461350     Document Type: Article

References (25)

1. Bawin, S. M., & Adey, W. R. (1977). Calcium binding in cerebral tissue. In D. G. Hazzard (Ed.), Symposium on Biological Effects and Measurement of Radio Frequency/Microwaves (pp. 305-313). Washington: U.S. Government Printing Office.
2. 2+ from chicken cerebral tissue by electromagnetic fields. Proceedings of the National Academy of Sciences U.S.A., 75, 6314-6318.
3. Del-Bel, E. A., Oliveira, P. J., Oliveira, J. A., Mishra, P. K., Jobe, P. C., & Garcia-Cairasco, N. (1997). Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models. Brazilian Journal of Medical and Biological Research, 30, 971-997.
4. Dzoljic, E., De Vries, R., & Dzoljic, M. R. (1997). Anticonvulsant activity of new and potent inhibitors of nitric oxide synthase. Brain Research Bulletin, 43, 191-195.
5. Harrigan, T., Bureau, Y. R. J., Persinger, M. A., & Parker, G. H. (1994). Prevention of sudden cardiac death by the atypical neuroleptic acepromazine following status epilepticus in rats. Life Sciences, 54, PL457-462.
6. Honchar, M. P., Olney, J. W., & Sherman, W. R. (1983). Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. Science, 220, 323-325.
7. Kavaliers, M., Choleris, E., Prato, F. S., & Ossenkopp, K. (1998). Evidence for the involvement of nitric oxide and nitric oxide synthase in the modulation of opioid-induced antinociception and the inhibitory effects of exposure to 60-Hz magnetic fields in the land snail. Brain Research, 809, 50-57.
8. Liboff, A. R. (1985). Cyclotron resonance in membrane transport. In A. Chiabrera, C. Nicolini, and H. P. Schwan (Eds.), Interactions between electromagnetic fields and cells (pp. 279-294). London: Plenum Press.
9. Liboff, A. R., Smith, S. D., & McLeod, B. R. (1987). Experimental evidence for ion cyclotron resonance mediation of membrane transport. In M. Blank and E. Findl (Eds.), Mechanistic approaches to interactions of electric and electromagnetic fields with living systems (pp. 109-132). London: Plenum Press.
10. 2-45 cyclotron resonance in human lymphocytes. Journal of Bioelectricity, 6, 13-22.
11. Maggio, R., Fumagalli, F., Donati, E., Barbier, P., Racagni, G., Corsini, G. U., & Riva, M. (1995). Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats. Brain Research, 679, 184-187.
12. McLeod, B. R. Smith, S. D., Cooksey, K. E., & Liboti, A. R. (1987). Ion cyclotron resonance frequencies enhance Ca++-dependent motility in diatoms. Journal of Bioelectricity, 6, 1-12.
13. Persinger, M. A., Makarec, K., & Bradley, J. C. (1988). Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine. Physiology and Behavior, 44, 27-37.
14. Persinger, M. A., Cook, L. L., & Koren, S. A. (2000). Suppression of experimental allergic encephalomyelitis in rats exposed nocturnally to magnetic fields. International Journal of Neuroscience, 100, 107-116.
15. Prato, F. S., Carson, J. J. L., Ossenkopp, K.-P., & Kavaliers, M. (1995). Possible mechanisms by which extremely low frequency magnetic fields affect opioid function. FASEB Journal, 9, 807-814.
16. Racine, R. J. (1992). Modification of seizure activity by electrical stimulation: II Motor seizure. Electroencephalography and Clinical Neurophysiology, 32, 281-294.
17. Starr, M., & Starr, B. S. (1993). Paradoxical facilitation of pilocarpine-induced seizures in the mouse by MK-801 and the nitric oxide synthesis inhibitor L-NAME. Pharmacology Biochemistry and Behavior, 45, 321-325.
18. Stewart, L. S., Leung, L. S., & Persinger, M. A. (2001). Diumal variation in pilocarpine-induced generalized tonic-clonic seizure activity. Epilepsy Research, 44, 207-212.
19. Thomas, J. R., Schrot, J., & Liboff, A. R. (1987). Low-intensity magnetic fields alter operant behavior in rats. Bioelectromagnetics, 7, 349-357.
20. Thomas, A. W., Kavaliers, M., Prato, F. S., & Ossenkopp, K. P. (1998). Analgesic effects of a specific pulsed magnetic field in the land snail, Cepaea nemoralis: Consequences of repeated exposures, relations to tolerance and cross-tolerance with DPDPE. Peptides, 19, 333-342.
21. Turski, W. A., Cavalheiro, E. A., Schwartz, M., Czuczwar, S. J., Kleinrok, Z., & Turski, L. (1983). Limbic seizures produced by pilocarpine in rats. Behavioral, electroencephalographic and neuropathological study. Behavioral Brain Research, 9, 315-334.
22. Turski, L., Ikonomidou, C., Cavalheiro, E. A., Kleinrok, Z., Czuczwar, S., & Turski, W. (1985). Effects of morphine and naloxone on pilocarpine-induced convulsions in rats. Neuropeptides, 5, 315-318
23. Turski, W. A., Bortolotto, Z. A., Ikonomidou-Turski, C., Moraes Mello, L. E., Cavalheiro, E. A., & Turski, L. (1986). The threshold for limbic seizures in rats is decreased by intranigral morphine. NIDA Research Monographs, 75, 547-550.
24. Tysdale, D. M., Lipa, S. M., Ossenkopp, K. P., & Kavaliers, M. (1991). Inhibitory effects of 60-Hz magnetic fields on opiate-induced "analgesia" in the land snail, Cepaea nemoralis, under natural conditions. Physiology and Behavior, 49, 53-56.
25. Van Leeuwen, R., De Vries, R., & Dzoljic, M. R. (1995). 7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures. European Journal of Pharmacology, 287, 211-223.