Expression of the tyrosine kinase c-kit is an independent prognostic factor in patients with small cell lung cancer

International Journal of Cancer

Volumn 111, Issue 2, 2004, Pages 259-263

  Rohr, Ulrich Peter ^a   Rehfeld, Nina ^a   Pflugfelder, Lucy ^a   Geddert, Helene ^a   Müller, Wolfram ^a   Steidl, Ulrich ^a   Fenk, Roland ^a   Gräf, Thorsten ^a   Schott, Matthias ^a   Thiele, Klaus Peter ^a   Erich Gabbert, Helmut ^a   Germing, Ulrich ^a   Kronenwett, Ralf ^a   Haas, Rainer ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

C kit; Multivariate analysis; Small cell lung cancer; Survival

Indexed keywords

LACTATE DEHYDROGENASE; PARAFFIN; PROTEIN TYROSINE KINASE; STEM CELL FACTOR;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RETROSPECTIVE STUDY;

AGED; CARCINOMA, SMALL CELL; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-KIT; SURVIVAL ANALYSIS;

EID: 3142770459     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20252     Document Type: Article

References (22)

1. Hibi K, Takahashi T, Sekido Y, Ueda R, Hida T, Ariyoshi Y, Takagi H, Takahashi T. Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer. Oncogene 1991;6:2291-6.
2. Rygaard K, Nakamura T, Spang-Thomsen M. Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter factor and stem cell factor, in SCLC cell lines and xenografts. Br J Cancer 1993;67:37-46.
3. Heinrich MC, Rubin BP, Longley BJ, Fletcher JA. Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum Pathol 2002;33:484-95.
4. Hida T, Ueda R, Sekido Y, Hibi K, Matsuda R, Ariyoshi Y, Sugiura T, Takahashi T, Takahashi T. Ectopic expression of c-kit in small-cell lung cancer. Int J Cancer Suppl 1994;8:108-9.
5. Papadimitriou CA, Topp MS, Serve H, Oelmann E, Koenigsmann M, Maurer J, Oberberg D, Reufi B, Thiel E, Berdel WE. Recombinant human stem cell factor does exert minor stimulation of growth in small cell lung cancer and melanoma cell lines. Eur J Cancer 1995; 31A:2371-8.
6. Krystal GW, Hines SJ, Organ CP. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor. Cancer Res 1996;56:370-6.
7. Sekido Y, Takahashi T, Ueda R, Takahashi M, Suzuki H, Nishida K, Tsukamoto T, Hida T, Shimokata K, Zsebo KM. Recombinant human stem cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c-kit protooncogene. Cancer Res 1993; 53:1709-14.
8. Yamanishi Y, Maeda H, Hiyama K, Ishioka S, Yamakido M. Specific growth inhibition of small-cell lung cancer cells by adenovirus vector expressing antisense c-kit transcripts. Jpn J Cancer Res 1996;87:534-42.
9. Potti A, Moazzam N, Ramar K, Hanekom DS, Kargas S, Koch M. CD117 (c-KIT) overexpression in patients with extensive-stage small-cell lung carcinoma. Ann Oncol 2003;14:894-7.
10. Tamberi S, Longo L, Rossi G, Migaldi M, Crino L, Cavazza A, Marchioni A, Bavieri M, Petruzzelli S. Loss of c-kit expression after chemotherapy in small cell lung cancer: therapeutic implications. Proc ASCO 2003;22. Abstract 2607.
11. Naeem M, Dahiya M, Clark JI, Creech SD, Alkan S. Analysis of c-kit protein expression in small-cell lung carcinoma and its implication for prognosis. Hum Pathol 2002;33:1182-7.
12. Micke P, Basrai M, Faldum A, Bittinger F, Ronnstrand L, Blaukat A, Beeh KM, Oesch F, Fischer B, Buhl R, Hengstler JG. Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications. Clin Cancer Res 2003;9:188-94.
13. Blackhall FH, Pintilie M, Michael M, Leighl N, Feld R, Tsao MS, Shepherd FA. Expression and prognostic significance of kit, protein kinase B, and mitogen-activated protein kinase in patients with small cell lung cancer. Clin Cancer Res 2003;9:2241-7.
14. Mountain CF. The international system for staging lung cancer. Semin Surg Oncol 2000;18:106-15.
15. Sekido Y, Obata Y, Ueda R, Hida T, Suyama M, Shimokata K, Ariyoshi Y, Takahashi T. Preferential expression of c-kit protooncogene transcripts in small cell lung cancer. Cancer Res 1991;51:2416-9.
16. Natali PG, Nicotra MR, Sures I, Santoro E, Bigotti A, Ullrich A. Expression of c-kit receptor in normal and transformed human non-lymphoid tissues. Cancer Res 1992;52:6139-43.
17. Onn A, Correa AM, Gilcrease M, Moran C, Roach JS, Isobe T, Bucana CD, Hong WK, Putnam JB, Herbst RS. Epidermal growth factor receptor, HER2, and c-Kit as predictors of outcome in stage I non-small cell lung cancer. Proc ASCO 2003;22. Abstract 2553.
18. Lasota J, Jasinski M, Sarlomo-Rikala M, Miettinen M. Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas. Am J Pathol 1999;154:53-60.
19. Joensuu H, Fletcher C, Dimitrijevic S, Silberman S, Roberts P, Demetri G. Management of malignant gastrointestinal stromal tumors. Lancet 2002;3:655-64.
20. Wang WL, Healy ME, Sattler M, Verma S, Lin J, Maulik G, Stiles CD, Griffin JD, Johnson BE, Salgia R. Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571. Oncogene 2000;19:3521-8.
21. Krystal GW, Honsawek S, Litz J, Buchdunger E. The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth. Clin Cancer Res 2000;6:3319-26.
22. Burger H, den Bakker MA, Stoter G, Verweij J, Nooter K. Lack of c-kit exon 11 activating mutations in c-KIT/CD117-positive SCLC tumour specimens. Eur J Cancer 2003;39:793-9.