A quantitative trait locus mixture model that avoids spurious LOD score peaks

Genetics

Volumn 167, Issue 2, 2004, Pages 959-965

  Feenstra, Bjarke ^a   Skovgaard, Ib M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE MAPPING; GENETIC LINKAGE; GENETIC MODEL; GENOME; GENOTYPE; MAXIMUM LIKELIHOOD METHOD; NORMAL DISTRIBUTION; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS;

GENETIC TECHNIQUES; LOD SCORE; MODELS, GENETIC; MODELS, THEORETICAL; QUANTITATIVE TRAIT LOCI;

EID: 3142754122     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.103.025437     Document Type: Article

References (14)

1. BROMAN, K. W., 2003 Mapping quantitative trait loci in the case of a spike in the phenotype distribution. Genetics 163: 1169-1175.
2. BROMAN, K. W., H. WU, Ś. SEN and G. A. CHURCHILL, 2003 R/qtl: QTL mapping in experimental crosses. Bioinformatics 19: 889-890.
3. DEMPSTER, A. P., N. M. LAIRD and D. B. RUBIN, 1977 Maximum likelihood from incomplete data via the EM algorithm. J. R. Stat. Soc. B 39: 1-38.
4. IHAKA, R., and R. GENTLEMAN, 1996 R: a language for data analysis and graphics. J. Comp. Graph. Stat. 5: 299-314.
5. KAO, C.-H., Z-B. ZENG and R. D. TEASDALE, 1999 Multiple interval mapping for quantitative trait loci. Genetics 152: 1203-1216.
6. KNOTT, S. A., and C. S. HALEY, 1992 Aspects of maximum likelihood methods for the mapping of quantitative trait loci in line crosses. Genet. Res. 60: 139-151.
7. KRUGLYAK, L., and E. S. LANDER, 1995 A nonparametric approach for mapping quantitative trait loci. Genetics 139: 1421-1428.
8. LANDER, E. S., and D. BOTSTEIN, 1989 Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199.
9. LYNCH, M., and B. WALSH, 1998 Genetics and Analysis of Quantitative Traits. Sinauer, Sunderland, MA.
10. MARTÍNEZ, O., and R. N. CURNOW, 1992 Estimating the locations and the sizes of the effects of quantitative trait loci using flanking markers. Theor. Appl. Genet. 85: 480-488.
11. ROSSINI, A., L. TIERNEY and N. LI, 2003 Simple parallel statistical computing in R. University of Washington Biostatistics Working Paper Series 193, University of Washington, Seattle.
12. VAN DER VAART, A. W., 1998 Asymptotic Statistics. Cambridge University Press, Cambridge, UK.
13. ZENG, Z-B., 1993 Theoretical basis of separation of multiple linked gene effects on mapping quantitative trait loci. Proc. Natl. Acad. Sci. USA 90: 10972-10976.
14. ZENG, Z-B., 1994 Precision mapping of quantitative trait loci. Genetics 136: 1457-1468.