Neither rofecoxib nor naproxen slows cognitive decline in people with mild-to-moderate Alzheimer's disease

Evidence-Based Healthcare

Volumn 7, Issue 4, 2003, Pages 200-201

  Aisen, P S ^a   Schafer, K A ^d   Grundman, M ^d   Knopman, David ^b   Tabet, Naji ^c  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF BRIGHTON   (United Kingdom)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; ANTIDEPRESSANT AGENT; ANTIINFLAMMATORY AGENT; ANTIPARKINSON AGENT; CHOLINESTERASE INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; ESTROGEN; FREE RADICAL; IBUPROFEN; INDOMETACIN; NAPROXEN; NEUROLEPTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; ROFECOXIB; SEDATIVE AGENT;

ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; BRAIN NERVE CELL; CLINICAL TRIAL; COGNITIVE DEFECT; DAILY LIFE ACTIVITY; DISEASE COURSE; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; GASTROINTESTINAL SYMPTOM; HUMAN; INCIDENCE; INFLAMMATION; INSTITUTIONAL CARE; LOW DRUG DOSE; NERVE CELL LESION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; QUALITY OF LIFE; RATING SCALE; SHORT SURVEY; UNITED STATES;

EID: 3142740879     PISSN: 14629410     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ehbc.2003.08.001     Document Type: Short Survey

References (7)

1. In t'Veld BA, Ruitenberg A, Hofman A et al. Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001; 345: 1515-1521.
2. Weggen S, Eriksen JL, Das P et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 2001; 414: 212-216.
3. Etminan M, Gill S, Samii A. Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ 2003; 327: 128-131.
4. Launder LJ. Nonsteroidal anti-inflammatory drugs and Alzheimer's disease: what next? JAMA 2003; 289: 2865-2867.
5. Rogers J, Kirby LC, Hempelman SR et al. Clinical trial of indomethacin in Alzheimer's disease. Neurology 1993; 43: 1609-1611.
6. Tabet N, Feldman H. Ibuprofen for Alzheimer's disease. Cochrane Database Syst Rev. 2003(2), CD 004031.
7. Tabet N, Feldman H. Indomethacin for the treatment of Alzheimer's disease patients. Cochrane Database Syst Rev. 2002(2), CDO03673.