Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): Identification of residues essential for enzyme activity and the Ca2+-induced conformational change

Biochemistry

Volumn 43, Issue 28, 2004, Pages 9185-9194

  Yang, Mingyan ^a   Kirley, Terence L ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BLOOD; CHEMICAL BONDS; DISEASES; HYDROLYSIS; ORGANIC ACIDS;

MUTATIONS; NUCLEOTIDASE ACTIVITIES;

ENZYMES;

ADENOSINE DIPHOSPHATE; ALANINE; APYRASE; ARGININE; ASPARTIC ACID; CALCIUM ION; CATION; GLUTAMIC ACID; HUMAN SOLUBLE CALCIUM ACTIVATED NUCLEOTIDASE 1; MAGNESIUM; NUCLEOTIDASE; STRONTIUM; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; FLUORESCENCE; HUMAN; HUMAN CELL; HYDROLYSIS; INSECT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; SITE DIRECTED MUTAGENESIS; THROMBOCYTE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CALCIUM; CATALYTIC DOMAIN; CATIONS, DIVALENT; CONSERVED SEQUENCE; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEOTIDES; PHOSPHORIC DIESTER HYDROLASES; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

HEXAPODA; INSECTA;

EID: 3142724825     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049565o     Document Type: Article

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