Dose properties of a laser accelerated electron beam and prospects for clinical application

Medical Physics

Volumn 31, Issue 7, 2004, Pages 2053-2067

  Kainz, K K ^a   Hogstrom, K R ^a   Antolak, J A ^a   Almond, P R ^a   Bloch, C D ^a   Chiu, C ^b   Fomytskyi, M ^b   Raischel, F ^b,c   Downer, M ^b   Tajima, T ^b,d  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d JAPAN ATOMIC ENERGY AGENCY   (Japan)

Author keywords

Dosimetry; Electron radiotherapy; Laser electron acceleration; LWFA

Indexed keywords

DOSIMETRY; ELECTRON BEAM LITHOGRAPHY; ELECTRON BEAMS; PARTICLE BEAM DYNAMICS; PETROLEUM PROSPECTING; PLASMA ACCELERATORS; PULSE REPETITION RATE; RADIOTHERAPY;

CLINICAL ELECTRON BEAMS; ENGINEERING DEVELOPMENT; FUNDAMENTAL PRINCIPLES; LASER ACCELERATED ELECTRONS; LASER ELECTRON ACCELERATION; LASER WAKEFIELD ACCELERATION; LWFA; RADIOTHERAPY APPLICATIONS;

ELECTRONS;

ALGORITHM; ARTICLE; DOSIMETRY; DUAL SCATTERING FOIL SYSTEM; ELECTRON ACCELERATOR; ELECTRON BEAM; LASER; LASER WAKEFIELD ACCELERATION; MEDICAL TECHNOLOGY; MONTE CARLO METHOD; PRIORITY JOURNAL; RADIATION DEPTH DOSE; RADIATION DOSE; RADIATION SCATTERING; RADIOTHERAPY; X RAY;

EID: 3142720342     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.1690194     Document Type: Article

References (35)

1. T. Tajima and J. M. Dawson, "Laser electron accelerator," Phys. Rev. Lett. 43, 267-270 (1979).
2. E. L. Clark, K. Krushelnick, J. R. Davies, M. Zepf, M. Tatarkis, F. N. Beg, A. Machacek, P. A. Norreys, M. I. K. Santala, I. Watts, and A. E. Dangor, "Measurements of energetic proton transport through magnetized plasma from intense laser interactions with solids," Phys. Rev. Lett. 84, 670-673 (2000).
3. A. Maksimchuk, S. Gu, K. Flippo, D. Umstadter, and V. Yu. Bychenkov, "Forward ion acceleration in thin films driven by a high-intensity laser," Phys. Rev. Lett. 84, 4108-4111 (2000).
4. T. E. Cowan, M. Roth, J. Johnson, C. Brown, M. Cristl, W. Fountain, S. Hatchett, E. A. Henry, A. W. Hunt, M. H. Key, A. MacKinnon, T. Parnell, D. M. Pennington, M. D. Perry, T. W. Phillips, T. C. Sangster, M. Singh, R. Snavely, M. Stoyer, Y. Takahashi, S. C. Wilks, and K. Yasuike, "Intense electron and proton beams from Peta Watt laser-matter interactions," Nucl. Instrum. Methods Phys. Res. A 455, 130-139 (2000).
5. M. Hegelich, S. Karsch, G. Pretzler, D. Habs, K. Witte, W. Guenther, M. Allen, A. Blazevic, J. Fuchs, J. C. Gauthier, M. Geissel, P. Audebert, T. Cowan, and M. Roth, "MeV ion jets from short-pulse-laser interaction with thin foils," Phys. Rev. Lett. 89, 085002 (2002).
6. M. Karlsson and B. Zackrisson, "Exploration of new treatment modalities offered by high energy (up to 50 MeV) electrons and photons," Radiother. Oncol. 43, 303-309 (1997).
7. D. D. Leavitt, J. R. Stewart, and L. Earley, "Improved dose homogeneity in electron arc therapy achieved by a multiple-energy technique," Int. J. Radiat. Oncol., Biol., Phys. 19, 159-165 (1990).
8. K. R. Hogstrom, J. A. Antolak, R. J. Kudchadker, C.-M. Ma, and D. D. Leavitt, "Modulated Electron Therapy," in Intensity Modulated Radiotherapy, edited by T. R. Mackie and J. R. Palta, Proceedings of the AAPM 2003 Summer School (Medical Physics Publishing, Madison, WI, 2003), pp. 749-786.
9. C. Chiu, M. Fomytskyi, F. Grigsby, F. Raischel, M. C. Downer, and T. Tajima, "Laser accelerators for radiation medicine: A feasibility study," Med. Phys. 31, 2042-2052 (2004).
10. E. Esarey, P. Sprangle, J. Krall, and A. Ting, "Overview of plasma-based accelerator concepts," IEEE Trans. Plasma Sci. 24, 252-288 (1996).
11. J. D. Jackson, Classical Electrodynamics, 2nd ed. (Wiley, New York, 1975), p. 492.
12. C. D. Decker, W. B. Mori, T. Katsouleas, and D. E. Hinkel, "Spatial temporal theory of Raman forward scattering," Phys. Plasmas 3, 1360-1372 (1996).
13. T. M. Antonsen, Jr. and P. Mora, "Self-focusing and Raman scattering of laser pulses in tenuous plasmas," Phys. Fluids B 5, 1440-1452 (1993).
14. J. Krall, A. Ting, E. Esarey, P. Sprangle, and G. Joyce, "Enhanced acceleration in a self-modulated laser wakefield accelerator," Phys. Rev. E 48, 2157-2161 (1993).
15. R. Wagner, S.-Y. Chen, A. Maksimchuk, and D. Umstadter, "Electron acceleration by a laser wakefield in a relativistically self-guided channel," Phys. Rev. Lett. 78, 3125-3128 (1997).
16. C. I. Moore, A. Ting, K. Krushelnick, E. Esarey, R. F. Hubbard, B. Hafizi, H. R. Burris, C. Manka, and P. Sprangle, "Electron trapping in self-modulated laser wakefields by Raman backscatter," Phys. Rev. Lett. 79, 3909-3912 (1997).
17. D. Gordon, K. C. Tzeng, C. E. Clayton, A. E. Dangor, V. Malka, K. A. Marsh, A. Modena, W. B. Mori, P. Muggli, Z. Najmudin, D. Neely, C. Danson, and C. Joshi, "Observation of electron energies beyond the linear dephasing limit from a laser-excited relativistic plasma wave," Phys. Rev. Lett. 80, 2133-2136 (1998).
18. W. P. Leemans, D. Rodgers, P. E. Catravas, C. G. R. Geddes, G. Fubiani, E. Esarey, B. A. Shadwick, R. Donahue, and A. Smith, "Gamma-neutron activation experiments using laser wakefield accelerators," Phys. Plasmas 8, 2510-2516 (2001).
19. D. L. Fisher and T. Tajima, "Enhanced Raman forward scattering," Phys. Rev. E 53, 1844-1851 (1996).
20. F. Raischel, "A laser electron accelerator system for radiation therapy," M.A. thesis, The University of Texas at Austin, 2001 (unpublished).
21. C. E. Clayton, K. A. Marsh, A. Dyson, M. Everett, A. Lala, W. P. Leemans, R. Williams, and C. Joshi, "Ultrahigh-gradient acceleration of injected electrons by laser-excited relativistic electron plasma waves," Phys. Rev. Lett. 70, 37-40 (1993).
22. D. Strickland and G. Mourou, "Comparison of amplified chirped optical pulses," Opt. Commun. 56, 219-221 (1985).
23. G. A. Mourou, C. P. J. Barty, and M. D. Perry, "Ultrahigh-intensity lasers: Physics of the extreme on a tabletop," Phys. Today 51, 22-28 (1998).
24. M. C. Downer, C. Chiu, M. Fomyts'kyi, E. W. Gaul, F. Grigsby, N. H. Matlis, B. Shim, P. J. Smith, and R. Zgadzaj, "Plasma channels and laser pulse tailoring for GeV laser-plasma accelerators," in Advanced Accelerator Concepts X, edited by C. E. Clayton and P. Muggli [AIP Conf. Proc. 647, 654-663 (2002)].
25. M. C. Downer, C. Chiu, M. Fomyts'kyi, E. W. Gaul, F. Grigsby, N. H. Matlis, B. Shim, P. J. Smith, and R. Zgadzaj, "Plasma channels and laser pulse tailoring for GeV laser-plasma accelerators," in Advanced Accelerator Concepts X, edited by C. E. Clayton and P. Muggli [AIP Conf. Proc. 647, 654-663 (2002)].
26. R. L. Jones III, "Compact laser-driven medical electron accelerators," M.A. thesis, The University of Texas at Austin, 1999 (unpublished).
27. E. Fourkal, B. Shahine, M. Ding, J. S. Li, T. Tajima, and C.-M. Ma, "Particle in cell simulation of laser-accelerated proton beams for radiation therapy," Med. Phys. 29, 2788-2798 (2002).
28. C. J. Karzmark, "Advances in linear accelerator design for radiotherapy," Med. Phys. 11, 105-128 (1984).
29. N. Leveson and C. Turner, "An Investigation of the Therac-25 Accidents," in Ethics and Computing: Living Responsibly in a Computerized World, edited by K. W. Bowyer (IEEE Computer Society Press, Los Alamitos, CA, 1996), pp. 18-41.
30. D. W. O. Rogers, B. A. Faddegon, G. X. Ding, C.-M. Ma, J. We, and T. R. Mackie, "BEAM: A Monte Carlo code to simulate radiotherapy treatment units," Med. Phys. 22, 503-524 (1995).
31. W. R. Nelson, H. Hirayama, and D. W. O. Rogers, "The EGS4 code system," Stanford Linear Accelerator Center Report No. SLAC-265, Stanford, CA, 1985.
32. A. D. Green, "Modeling of dual foil scattering systems for clinical electron beams," M. S. thesis, The University of Texas Health Science Center at Houston, 1991 (unpublished).
33. H. Huizenga and P. R. M. Storchi, "Numerical calculation of energy deposition by broad high-energy electron beams," Phys. Med. Biol. 34, 1371-1396 (1989).
34. ICRU, "Radiation dosimetry: Electron beams with energies between 1 and 50 MeV," ICRU Report No. 35, Bethesda, MD, 1984.
35. V. Bagnoud and F. Salin, "Amplifying laser pulses to the terawatt level at a 1-kilohertz repetition rate," Appl. Phys. B: Lasers Opt. 70, S165-S170 (2000).