Transforming growth factor-β (TGF-β)-resistant B cells from chronic lymphocytic leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-β receptor

Cancer Detection and Prevention

Volumn 28, Issue 1, 2004, Pages 57-64

  Schiemann, William P ^a   Rotzer, Diana ^b   Pfeifer, Waither M ^d   Levi, Edi ^d   Rai, Kanti R ^c   Knaus, Petra ^b   Kadin, Marshall E ^d  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Chronic lymphocytic leukemia; Mutations; Receptor; TGF

Indexed keywords

SIGNAL PEPTIDE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; B LYMPHOCYTE; CELL CULTURE; CHRONIC LYMPHATIC LEUKEMIA; COMPARATIVE STUDY; DRUG EFFECT; DRUG RESISTANCE; GENETIC PREDISPOSITION; GENETICS; HUMAN; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY;

B-LYMPHOCYTES; BASE SEQUENCE; CELLS, CULTURED; DRUG RESISTANCE, NEOPLASM; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; PROTEIN SORTING SIGNALS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SENSITIVITY AND SPECIFICITY; TRANSFORMING GROWTH FACTOR BETA;

EID: 3142715934     PISSN: 0361090X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cdp.2003.11.001     Document Type: Article

References (28)

1. Blobe G.C., Schiemann W.P., Lodish H.F. Role of transforming growth factor β in human disease. N. Engl. J. Med. 342:2000;1350-1358.
2. Massague J., Blain S.W., Lo R.S. TGF-β signaling in growth control, cancer, and heritable disorders. Cell. 103:2000;295-309.
3. Pasche B. Role of transforming growth factor β in cancer. J. Cell Physiol. 186:2001;153-168.
4. Kleeff J., Ishiwata T., Maruyama H., Friess H., Truong P., Buchler M.W. et al. The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. Oncogene. 18:1999;5363-5372.
5. Schiemann W.P., Pfeifer W.M., Levi E., Kadlin M.E., Lodish H.F. A deletion in the gene for transforming growth factor β type I receptor abolishes growth regulation by TGF-β in a cutaneous T-cell lymphoma. Blood. 94:1999;2854-2861.
6. Reed J.C. Molecular biology of chronic lymphocytic leukemia. Semin Oncol. 25:1998;11-18.
7. Montserrat E., Bosch F., Rozman C. B-cell chronic lymphocytic leukemia: recent progress in biology, diagnosis, and therapy. Ann. Oncol. 8:1997;S93-S101.
8. Letterio J.J., Roberts A.B. Regulation of immune responses by TGF-β Ann. Rev. Immunol. 16:1998;137-161.
9. Perlman R., Schiemann W.P., Brooks M.W., Lodish H.F., Weinberg R.A. TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Natl. Cell Biol. 3:2001;708-714.
10. DeCoteau J.F., Knaus P.I., Yankelev H., Reis M.D., Lowsky R., Lodish H.F.et al. Loss of functional cell surface transforming growth factor β (TGF-β) type I receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. U.S.A. 94:1997;5877-5881.
11. Moustakas A., Takumi T., Lin H.Y., Lodish H.F. GH3 pituitary tumor cells contain heteromeric type I and type II receptor complexes for transforming growth factor β and activin-A. J. Biol. Chem. 270:1995;765-769.
12. Lin H.Y., Wang X.F., Ng-Eaton E., Weinberg R.A., Lodish H.F. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell. 68:1992;775-785.
13. Boyd F.T., Massague J. Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53. kDa membrane receptor J. Biol. Chem. 264:1989;2272-2278.
14. Wrana J.L., Attisano L., Carcamo J. TGF-β signals through a heteromeric protein kinase receptor complex. Cell. 71:1992;1003-1014.
15. Chen T., de Vries E.G., Hollema H., Yegen H.A., Vellucci V.F., Strickler H.D.et al. Structural alterations of transforming growth factor-β receptor genes in human cervical carcinoma. Int. J. Cancer. 82:1999;43-51.
16. Pasche B., Luo Y., Rao P.H., Nimer S.D., Dmitrovsky E., Caron P.et al. Type I transforming growth factor β receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract. Cancer Res. 58:1998;2727-2732.
17. Pasche B., Kolachana P., Nafa K., Satagopan J., Chen Y.G., Lo R.S.et al. TβR-I(6A) is a candidate tumor susceptibility allele. Cancer Res. 59:1999;5678-5682.
18. Douglas R.S., Capocasale R.J., Lamb R.J., Nowell P.C., Moore J.S. Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-β Blood. 89:1997;941-947.
19. Lagneaux L., Delforge A., Bernier M., Stryckmans P., Bron D. TGF-β activity and expression of its receptors in B-cell chronic lymphocytic leukemia. Leuk. Lymphoma. 31:1998;99-106.
20. Lagneaux L., Delforge A., Bron D., Massy M., Bernier M., Stryckmans P. Heterogenous response of B lymphocytes to transforming growth factor-β in B-cell chronic lymphocytic leukaemia: correlation with the expression of TGF-β receptors. Br. J. Haematol. 97:1997;6l2-620.
21. Douglas R.S., Woo E.Y., Capocasale R.J., Tarshis A.D., Nowell P.C., Moore J.S. Altered response to and production of TGF-β by B cells from autoimmune NZB mice. Cell Immunol. 179:1997;126-137.
22. Lagneaux L., Delforge A., Dorval C., Bron D., Stryckmans P. Excessive production of transforming growth factor-β by bone marrow stromal cells in B-cell chronic lymphocytic leukemia inhibits growth of hematopoietic precursors and interleukin-6 production. Blood. 82:1993;2379-2385.
23. Lotz M., Ranheim E., Kipps T.J. Transforming growth factor β as endogenous growth inhibitor of chronic lymphocytic leukemia B cells. J. Exp. Med. 179:1994;999-1004.
24. Friedenberg W.R., Salzman S.A., Burmester J.K. Transforming growth factor-β and multidrug resistance in chronic lymphocytic leukemia. Med. Oncol. 16:1999;110-118.
25. Piek E., Moustakas A., Kurisaki A., Heldin C.H., ten Dijke P. TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J. Cell Sci. 112:1999;4557-4568.
26. Massague J., Andres J., Attisano L., Cheifetz S., Lopez-Casillas F., Ohtsuki M.et al. TGF-β receptors. Mol. Reprod. Dev. 32:1992;99-104.
27. Kang S.H., Bang Y.J., Im Y.H., Yang H.K., Lee D.A., Lee H.Y.et al. Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer. Oncogene. 18:1999;7280-7286.
28. Paterson I.C., Matthews J.B., Huntley S., Huntley S., Robinson C.M., Fahey M.et al. Decreased expression of TGF-β cell surface receptors during progression of human oral squamous cell carcinoma. J. Pathol. 193:2001;458-467.