The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins (Bax and Bcl-2) in experimentally induced varicocele

Urological Research

Volumn 32, Issue 3, 2004, Pages 204-208

  Onur, R ^a   Semercioz A ^a   Orhan, I ^a   Yekeler, H ^a  

^a FIRAT UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Bax; Bcl 2; Melatonin; Reactive oxygen species; Varicocele

Indexed keywords

ANTIOXIDANT; CATALASE; GLUTATHIONE SYNTHASE; MALONALDEHYDE; MELATONIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DOSE TIME EFFECT RELATION; EXPERIMENTAL MODEL; HOMOGENATE; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OXIDATION KINETICS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TESTIS; TESTIS INJURY; VARICOCELE;

EID: 3142714379     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00240-004-0403-0     Document Type: Article

References (25)

1. Adams JM, Cory S (1998) The bcl-2 protein family: Arbiters of cell survival, Science 281: 1322
2. Bergmeyer HU (1974) Methods of enzymatic analysis. Academic Press, New York, p 438
3. Bornman MS (1989) Melatonin and sperm motility. Andrologia 21: 483
4. Cano A, Alcaraz O, Arnao MB (2003) Free radical-scavenging activity of indolic compounds in aqueous and ethanolic media. Anal Bioanal Chem 376: 33
5. Choi H, Kim KS, Kim KM (1990) The effect of experimental varicocele on the testis of adolescent rats. J Urol 144: 499
6. Curtin JF, Donovan M, Cotter TG (2002) Regulation and measurement of oxidative stress in apoptosis. J Immunol Meth 265: 49
7. Dubin L, Amelar D (1978) Varicocele. Urol Clin North Am 5: 563
8. Durak I, Yurtarslani Z, Canbolat O, Akyol O (1993) A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clin Chem Acta 214: 103
9. Hikim SAP, Swerdloff RS (1999) Hormonal and genetic control of germ cell apoptosis in the testis. Rev Reprod 4:38
10. Ikeda M, Kodama H, Fukuda J, Shimizu Y, Murata M, Kumagai J, Tanaka T (1999) Role of radical oxygen species in rat testicular germ cell apoptosis induced by heat stress. Biol Reprod 61: 393
11. Karaburun Paker S, Kilicarslan B, Ciftcioglu A, Oztekin S, Sargin FC, Erdogru T, Baykara M (2001) Relationship between apoptosis regular proteins (bcl-2 and p-53) and gleason score in prostate cancer. Pathol Oncol Res 7: 209
12. Kazez A, Demirbag A, Üstündag B, Ozercan IH, Saglam M (2000) The role of melatonin in prevention of intestinal ishchemia reperfusion injury in rats. J Pediatr Surg 5: 1444
13. Knudson CM, Tung KS, Toutellotte WG, Brown GAJ, Korsmeyer SJ (1995) Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270: 96
14. Lennon SV, Martin SJ, Cotter TG (1991) Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif 24: 203
15. Lin WW, Lamb DJ, Wheeler TM, Lipshults LI, Kim ED (1997) In situ end-labeling of human testicular tissue demonstrates increased apoptosis in conditions of abnormal spermatogenesis. Fertil Steril 68: 1065
16. Lue Y, Sinha Hikim AP, Swerdloff RS et al. (1999) Single exposure to heat induces stage-specific germ cell apoptosis in rats: role of intratesticular testosterone on stage specificity. Endocrinology 140: 1709
17. Luboshitzky R, Shen-Orr Z, Nave R, Lavi S, Lavie P (2002) Melatonin administration alters semen quality in healthy men. J Androl 23: 572
18. McGowan AJ, Fernandes RS, Samali A, Cotter TG (1996) Anti-oxidants and apoptosis. Biochem Soc Trans 24: 229
19. Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158
20. Reiter RJ, Tan DX, Poeggeler B, Menendez-Palaez A, Chen LD, Saarela S (1994) Melatonin as a free radical scavenger: implications for aging and age-related diseases. Ann N Y Acad Sci 31: 1
21. Satoh K (1978) Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chem Acta 90: 37
22. Semercioz A, Onur R, Ogras S, Orhan I (2003) Effects of melatonin on testicular tissue nitric oxide level and antioxidant enzyme activities in experimentally induced left varicocele. Neuroendocrinol Lett 24: 86
23. Suzuki N, Sofitikis N (1999) Protective effects of antioxidants on testicular function of varicocelized rats. Yonago Acta Med 42: 87
24. Simsek F, Türkeri L, Çevik I, Bircan K, Akdas A (1998) Role of apoptosis in testicular tissue damage caused by varicocele. Arch Esp Urol 51: 947
25. Yagi K (1984) Assay of blood plasma or serum. Methods Enzymol 105: 328