In situ observation of the four-step dehydration process of the 1 β-methylcarbapenem antibiotic CS-834 crystal by X-rays

Chemical and Pharmaceutical Bulletin

Volumn 51, Issue 12, 2003, Pages 1356-1362

  Kobayashi, Katsuhiro ^a,b   Fukuhara, Hiroshi ^a   Hata, Tadashi ^a   Ohashic, Yuji ^b  

^a DAIICHI SANKYO CO   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

1 methylcarbapenem antibiotic; Crystal structure; Dehydration; Hydrate; Hydrogen bond system; Single crystal X ray analysis

Indexed keywords

1BETA METHYLCARBAPENEM DERIVATIVE; 6 (1 HYDROXYETHYL) 4 METHYL 7 OXO 3 (5 OXO 3 PYRROLIDINYLTHIO) 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID PIVALOYLOXYMETHYL ESTER; SOLVENT; WATER; 1 BETA METHYLCARBAPENEM; 1 BETA-METHYLCARBAPENEM; ANTIINFECTIVE AGENT; CARBAPENEM DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG FORMULATION; DRUG SOLUBILITY; HUMIDITY; HYDRATION; HYDROGEN BOND; MICROSCOPY; X RAY POWDER DIFFRACTION; CHEMISTRY; DESICCATION; METHODOLOGY; X RAY DIFFRACTION;

ANTI-BACTERIAL AGENTS; CARBAPENEMS; DESICCATION; X-RAY DIFFRACTION;

EID: 3142711838     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.51.1356     Document Type: Article

References (17)

1. Vippagunta S. R., Brittain H. G., Grant D. J. W., Adv. Drug Del. Rev., 48, 3-26 (2001).
2. Kitamura S., Chang L., Guillory J. K., Int. J. Pharmaceut., 101, 127-144 (1994).
3. Wang S. L., Lin S. Y., Chen T. F., Chem. Pharm. Bull., 48, 1890-1893 (2000).
4. Sheng J., Venkatesh G. M., Duddu S. P., Grant D. J. W., J. Pharm. Sci., 88, 1021-1020 (1999).
5. Leung S. S., Padden B. E., Munson E. J., Grant D. J. W., J. Pharm. Sci., 87, 508-513 (1998).
6. Kitaoka H., Wada C., Moroi R., Hakusui H., Chem. Pharm. Bull., 43, 649-653 (1995).
7. Shefter E., Higuchi T., J. Pharm. Sci., 52, 781-791 (1963).
8. Khankari R. K., Grant D. J. W., Thermchim. Acta, 248, 61-79 (1995).
9. Miyauchi M., Endo R., Hisaoka M., Yasuda H., Kawamoto I., J. Antibiot., 50, 429-439 (1997).
10. Kobayashi K., Fukuhara H., Kawamoto I., Hata T., Sekine A., Uekusa H., Ohashi Y., Chem. Pharm. Bull., 50, 1570-1573 (2002).
11. Sugawara Y., Kamiya N., Iwasaki H., Ito T., Satoh Y., J. Am. Chem. Soc., 113, 5440-5445 (1991).
12. Sugawara Y., Nakamura A., Iimura Y., Kobayashi K., Urabe H., J. Phys. Chem. B, 106, 10363-10368 (2002).
13. Stokes R. H., Ind. Eng. Chem., 41, 2013 (1949).
14. Altomare A., Burla M. C., Camalli M., Cascarano G. L., Giacovazzo C., Guagliardi A., Moliterni A. G. G., Polidori G., Spagna R., J. Appl. Crystallogr., 32, 115-119 (1999).
15. Sheldrick G. M., SHELXL-97, University of Goettingen, Germany, 1997.
16. Kobayashi K., Fukuhara H., Kawamoto I., Ito S., Hata T., Anal. Sci., 17, 357-358 (2001).
17. Kobayashi K., Fukuhara H., Kawamoto I., Furukawa Y., Hata T., Anal. Sci., 16, 555-556 (2000).