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Drug Discovery Today
Volumn 9, Issue 14, 2004, Pages 592-
Metabolic ménages à trois: What does it mean for drug design?
Author keywords

cytochrome P450; drug design; Drug Discovery; enzymes; kinetics; Pharmaceutical Science
Indexed keywords

ALLOSTERISM; BINDING AFFINITY; DRUG DESIGN; ENZYME SUBSTRATE COMPLEX; SHORT SURVEY;
EID: 3142654675     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(04)03109-5     Document Type: Note
Times cited : (2)
References (5)
  • 1
    • 2442626615 scopus 로고    scopus 로고
    • Implications of the allosteric kinetcs of cytochrome P450s
    • Atkins W.M. Implications of the allosteric kinetcs of cytochrome P450s. Drug Discov. Today. 9:2004;478-484
    • (2004) Drug Discov. Today , vol.9 , pp. 478-484
    • Atkins, W.M.1
  • 2
    • 0024269576 scopus 로고
    • Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome P-450 3c
    • Johnson E.F., et al. Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome P-450 3c. J. Biol. Chem. 263:1988;17672-17677
    • (1988) J. Biol. Chem. , vol.263 , pp. 17672-17677
    • Johnson, E.F.1
  • 3
    • 0034962557 scopus 로고    scopus 로고
    • Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome P450 active sites
    • Ekins S., et al. Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome P450 active sites. Drug Metab. Dispos. 29:2001;936-944
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 936-944
    • Ekins, S.1
  • 4
    • 0000574406 scopus 로고    scopus 로고
    • Evaluation of atypical cytochrome P450 kinetics with two-substrate models: Evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites
    • Korzekwa K.R., et al. Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites. Biochemistry. 37:1998;4137-4147
    • (1998) Biochemistry , vol.37 , pp. 4137-4147
    • Korzekwa, K.R.1
  • 5
    • 0034724310 scopus 로고    scopus 로고
    • Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity
    • Cupp-Vickery J., et al. Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity. Proc. Natl. Acad. Sci. U. S. A. 97:2000;3050-3055
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 3050-3055
    • Cupp-Vickery, J.1

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.