Assessment of dietary exposure to the natural toxin hypoglycin in ackee (Blighia sapida) by Jamaican consumers

Food Research International

Volumn 37, Issue 8, 2004, Pages 833-838

  Blake, Orane A ^a,d   Jackson, José C ^a,c   Jackson, Maria A ^a   Gordon, C L André ^b  

^a UNIVERSITY OF THE WEST INDIES   (Jamaica)

^b Technological Solutions Limited   (Jamaica)

^c Natl Food Technol Research Centre   (Botswana)

^d PURDUE UNIVERSITY   (United States)

Author keywords

Ackee; Ackee consumption; Dietary exposure; Hypoglycin; Jamaica; Natural toxin

Indexed keywords

CONSUMER PRODUCTS; ECONOMIC AND SOCIAL EFFECTS; NUTRITION; RISK ASSESSMENT; TOXICITY;

DIETARY EXPOSURE; HYPOGLYCIN (HG);

FOOD PRODUCTS;

BLIGHIA; BLIGHIA SAPIDA;

EID: 3142647784     PISSN: 09639969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodres.2004.05.003     Document Type: Article

References (23)

1. Baldwin J.E., Adlington R.M., Bebbington D., Russell A.T. Asymmetric total synthesis of the Individual diastereomers of hypoglycin A. Tetrahedron. 50(41):1994;12015
2. Baldwin J.E., Parker D.W. Stereospecific (methylenecyclopropyl) acetyl CoA inactivation of general acy CoA dehydrogenase from pig kidney. Journal of Organic Chemistry. 52(8):1987;1475-1477
3. Billington D., Osmundsen H., Sherratt H.S. Mechanisms of the metabolic disturbances caused by hypoglycin and by pent 4-enoic acid in vivo studies. Biochemical Pharmacology. 27:1978;2891-2900
4. Bressler R., Corridor C., Brendel K. Hypoglycin and hypoglycin like compounds. Pharmacological Reviews. 21(2):1969;105
5. Brown M., Bates R.P., Mcgowan C., Cornell J.A. Influence of fruit maturity on the hypoglycin A level in ackee (Blighia sapida). Journal of Food Safety. 12(2):1992;167
6. Food and Drug Administration (FDA). Center for Food Safety and Applied Nutrition (CFSAN). (2000). Import Alert # 21-11, Detention without physical examination of Ackees (All Types) due to contamination by natural toxins
7. Fowden L. Hypoglycin and related compounds: Occurrence, isolation and biosynthesis. Kean E.A. Hypoglycin. 1978;Academic Press, New York
8. Hassall C.H., Hill K.R. The toxicity of the ackee and its relationship to the vomiting sickness of Jamaica. West Indian Medical Journal. 4:1955;83
9. Hill K.R. The vomiting sickness of Jamaica. West Indian Medical Journal. 1:1952;243
10. Jackson M., Walker S., Cade J., Forrester T., Cruickshank J.K., Wilks R. Reproducibility and validity of a quantitative food frequency questionnaire among Jamaicans of African origin. Public Health Nutrition. 4(5):2001;971-980
11. Kean E.A. Improved method for isolation of hypoglycins A and B from fruit of Blighia sapida. Journal of Pharmacology and Pharmacognosy. 26:1974;639
12. Kean E.A. Hypoglycin. Cheeke P.R. Toxicants of plant origin: Proteins and amino acids. 1989;229 CRC Press Inc, Boca Raton, FL
13. Manchester K.L. Biochemistry of hypoglycin. FEBS Letters. 40:1974;S133-S139
14. Ming-tain Lai D.L., Eugene Oh, Hung-wen Liu Mechanistic study on the inactivation of general Acyl-CoA dehydrogenase by a metabolite of hypoglycin A. Journal of the American Chemical Society. 113:1991;7388-7397
15. Ming-tain Lai D.L., Eugene Oh, Hung-wen Liu Studies of the inactivation of general Acyl-CoA dehydrogenase by (1R) and (1S)-(methylenecyclopropyl) acetyl-CoA. Bioorganic and Medical Chemistry Letters. 2:1992;1423
16. Ming-tain Lai D.L., Eugene Oh, Hung-wen Liu Inactivation of medium-chain acyl-CoA dehydrogenase by a metabolite of hypoglycin: Characterization of the major turnover product and evidence suggesting an alternative flavin modification pathway. Journal of the American Chemical Society. 115:1993;5
17. Ministry of Health (MOH), Jamaica. (1999). Poisonous substances surveillance report. Epidemiology Unit, Ministry of Health, Jamaica
18. Personal Communication (2000). The Ackee Industry of Jamaica
19. Sarwar G., Botting H.G. Reversed-phase liquid chromatographic determination of hypoglycin A (HG-A) in canned ackee fruit samples. Journal of AOAC International. 77:1994;5
20. Statistical Institute of Jamaica (STATIN) (2001). Demographic statistics 2001. The statistical institute of Jamaica, Kingston 10, Jamaica
21. Tanaka K., Isselbacher K.J., Shih V. Isovaleric and α-methylbutyric acidemias induced by hypogycin A: Mechanism of Jamaican vomiting sickness. Science. 175:1972;69
22. Tanaka K., Kean E.A., Johnson B. Jamaican vomiting sickness, biochemical investigation of two cases. New England Journal of Medicine. 295(9):1976;461-467
23. Von Holt V.H.M., Bohm H. Metaboblic effects of methylenecyclo- propaneacetic acid, a metabolite of hypoglycin. Biochimica et Biophysica Acta. 125(1):1966;1