Age-associated B vitamin deficiency as a determinant of chronic diseases

Nutrition Research Reviews

Volumn 17, Issue 1, 2004, Pages 55-68

  Brachet, Patrick ^a   Chanson, Aurélie ^a   Demigné, Christian ^a   Batifoulier, Frédérique ^a   Alexandre Gouabau, Marie Cécile ^a   Tyssandier, Viviane ^a   Rock, Edmond ^a  

^a CEMAGREF   (France)

Author keywords

Ageing; B vitamin deficiency; Degenerative diseases; Micronutrients

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CYANOCOBALAMIN; FOLIC ACID; METHIONINE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; VITAMIN B GROUP;

ABSORPTION; AGING; CANCER; CARDIOVASCULAR DISEASE; CELL TRANSPORT; CHRONIC DISEASE; CLINICAL TRIAL; DEGENERATIVE DISEASE; DEMENTIA; DRUG USE; ENVIRONMENTAL FACTOR; GENDER; GENETICS; HEALTH CARE COST; HUMAN; HYPERHOMOCYSTEINEMIA; LIFESTYLE; META ANALYSIS; METABOLISM; METHYLATION; NEUROLOGIC DISEASE; NONHUMAN; NUTRITION; PUBLIC HEALTH; REVIEW; RISK FACTOR; SYSTEMATIC REVIEW; VITAMIN DEFICIENCY; VITAMIN SUPPLEMENTATION;

EID: 3142635727     PISSN: 09544224     EISSN: None     Source Type: Journal    
DOI: 10.1079/NRR200478     Document Type: Review

References (145)

1. Achon M, Alonso-Aperts E & Varela-Moreiras G (2002) High dietary folate supplementation: effects on diet utilization and methionine metabolism in aged rats. Journal of Nutrition, Health and Aging 6, 51-54.
2. AFSSA & CNERNA-CNRS (2001) Apports Nutritionnels Conseillés pour la Population Française, 3rd ed. Paris: Technique & Documentation.
3. Amorim Cruz JA, Moreiras O & Brzozowska A (1996) Longitudinal changes in the intake of vitamins and minerals of elderly Europeans. SENECA Investigators. European Journal of Clinical Nutrition 50, Suppl. 2, S77-S85.
4. Baik HW & Russell RM (1999) Vitamin B12 deficiency in the elderly. Annual Review of Nutrition 19, 357-377.
5. Bailey LB, Cerda JJ, Bloch BS, Busby MJ, Vargas L, Chandler CJ & Halsted CH (1984) Effect of age on poly- and monoglutamyl folacin absorption in human subjects. Journal of Nutrition 114, 1770-1776.
6. Bailey AL, Maisey S, Southon S, Wright AJ, Finglas PM & Fulcher RA (1997) Relationships between micronutrient intake and biochemical indicators of nutrient adequacy in a 'free-living' elderly UK population. British Journal of Nutrition 77, 225-242.
7. Bailey LB, Rampersaud GC & Kauwell GP (2003) Folic acid supplements and fortification affect the risk for neural tube defects, vascular disease and cancer: evolving science. Journal of Nutrition 133, 1961S-1968S.
8. Benderitter M, Hadj-Saad F, Lhuissier M, Maupoil V, Guilland JC & Rochette L (1996) Effects of exhaustive exercise and vitamin B6 deficiency on free radical oxidative process in male trained rats. Free Radical Biology and Medicine 21, 541-549.
9. Bernstein MA, Tucker KL, Ryan ND, O'Neill EF, Clements KM, Nelson ME, Evans WJ & Fiatarone Singh MA (2002) Higher dietary variety is associated with better nutritional status in frail elderly people. Journal of the American Dietetic Association 102, 1096-1104.
10. Bird CL, Swendseid ME, Witte JS, Shikany JM, Hunt IF, Frankl HD, Lee ER, Longnecker MP & Haile RW (1995) Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps. Cancer Epidemiology, Biomarkers and Prevention 4, 709-714.
11. Björkegren K & Svärdsudd K (2001) Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes - a population-based study. Journal of Internal Medicine 249, 423-432.
12. Boisvert WA, Castaneda C, Mendoza I, Langeloh G, Solomons NW, Gershoff SN & Russell RM (1993) Prevalence of riboflavin deficiency among Guatemalan elderly people and its relationship to milk intake. American Journal of Clinical Nutrition 58, 85-90.
13. Boushey CJ, Beresford SA, Omenn GS & Motulsky AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. Journal of the American Medical Association 274, 1049-1057.
14. Broekmans WM, Klopping-Ketelaars IA, Schuurman CR, Verhagen H, van den Berg H, Kok FJ & van Poppel G (2000) Fruits and vegetables increase plasma carotenoids and vitamins and decrease homocysteine in humans. Journal of Nutrition 130, 1578-1583.
15. Brouwer IA, van Dusseldorp M, West CE, Meyboom S, Thomas CM, Duran M, van het Hof KH, Eskes TK, Hautvast JG & Steegers-Theunissen RP (1999) Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. Journal of Nutrition 129, 1135-1139.
16. Brouwer IA, van Dusseldorp M, West CE & Steegers-Theunissen RPM (2001) Bioavailability and bioefficacy of folate and folic acid in man. Nutrition Research Reviews 14, 267-293.
17. Camilo E, Zimmerman J, Mason JB, Golner B, Russell R, Selhub J & Rosenberg IH (1996) Folate synthesized by bacteria in the human upper small intestine is assimilated by the host. Gastroenterology 110, 991-998.
18. Chasan-Taber L, Selhub J, Rosenberg IH, Malinow MR, Terry P, Tishler PV, Willett W, Hennekens CH & Stampfer MJ (1996) A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians. Journal of the American College of Nutrition 15, 136-143.
19. Choi SW & Mason JB (2002) Folate status: effects on pathways of colorectal carcinogenesis. Journal of Nutrition 132, 2413S-2418S.
20. Choumenkovitch SF, Selhub J, Wilson PW, Rader JI, Rosenberg IH & Jacques PF (2002) Folic acid intake from fortification in United States exceeds predictions. Journal of Nutrition 132, 2792-2798.
21. Clarke R, Refsum H, Birks J, Evans JG, Johnston C, Sherliker P, Ueland PM, Schneede J, McPartlin J, Nexo E & Scott JM (2003) Screening for vitamin B-12 and folate deficiency in older individuals. American Journal of Clinical Nutrition 77, 1241-1247.
22. de Bree A, Verschuren WM, Bjorke-Monsen AL, van der Put NM, Heil SG, Trijbels FJ & Blom HJ (2003) Effect of the methylenetetrahydrofolate reductase 677C→T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. American Journal of Clinical Nutrition 77, 687-693.
23. de Jong N, Paw MJ, de Groot LC, Rutten RA, Swinkels DW, Kok FJ & van Staveren WA (2001) Nutrient-dense foods and exercise in frail elderly: effects on B vitamins, homocysteine, methylmalonic acid, and neuropsychological functioning. American Journal of Clinical Nutrition 73, 338-346.
24. Desouza C, Keebler M, McNamara DB & Fonseca V (2002) Drugs affecting homocysteine metabolism: impact on cardiovascular risk. Drugs 62, 605-616.
25. Doshi SN, McDowell IF, Moat SJ, Payne N, Durrant HJ, Lewis MJ & Goodfellow J (2002) Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation 105, 22-26.
26. Duan W, Ladenheim B, Cutler RG, Kruman, II, Cadet JL & Mattson MP (2002) Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. Journal of Neurochemistry 80, 101-110.
27. Duell PB & Malinow MR (1997) Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease. Current Opinion in Lipidology 8, 28-34.
28. Duthie SJ, Narayanan S, Brand GM, Pirie L & Grant G (2002) Impact of folate deficiency on DNA stability. Journal of Nutrition 132, 2444S-2449S.
29. Ervin RB, Wright JD & Kennedy-Stephenson J (1999) Use of dietary supplements in the United States, 1988-94. Vital and Health Statistics. Series 11, i-iii, 1-14.
30. Essama-Tjani JC, Guilland JC, Potier de Courcy G, Fuchs F & Richard D (2000) Folate status worsens in recently institutionalized elderly people without evidence of functional deterioration. Journal of the American College of Nutrition 19, 392-404.
31. Eussen SJ, Ferry M, Hininger I, Haller J, Matthys C & Dirren H (2002) Five year changes in mental health and associations with vitamin B12/folate status of elderly Europeans. Journal of Nutrition, Health and Aging 6, 43-50.
32. Expert Group on Vitamins and Minerals (2003) Safe upper levels for vitamins and minerals: report. www.foodstandards.gov.uk/science/ouradvisors/ vitandmin/
33. Fenech M (2002) Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs). Food and Chemical Toxicology 40, 1113-1117.
34. Feskanich D, Singh V, Willett WC & Colditz GA (2002) Vitamin A intake and hip fractures among postmenopausal women. Journal of the American Medical Association 287, 47-54.
35. Finkelstein JD (1998) The metabolism of homocysteine: pathways and regulation. European Journal of Pediatrics 157, Suppl. 2, S40-S44.
36. Flood VM, Webb KL, Smith W, Mitchell P, Bantick JM, Macintyre R, Sindhusake D & Rubin GL (2001) Folate fortification: potential impact on folate intake in an older population. European Journal of Clinical Nutrition 55, 793-800.
37. Folsom AR, Nieto FJ, McGovern PG, Tsai MY, Malinow MR, Eckfeldt JH, Hess DL & Davis CE (1998) Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. Circulation 98, 204-210.
38. Fuchs CS, Willett WC, Colditz GA, Hunter DJ, Stampfer MJ, Speizer FE & Giovannucci EL (2002) The influence of folate and multivitamin use on the familial risk of colon cancer in women. Cancer Epidemiology, Biomarkers and Prevention 11, 227-234.
39. Gastaldi G, Laforenza U, Ferrari G, Casasco A & Rindi G (1992) Age-related thiamin transport by small intestinal microvillous vesicles of rat. Biochimica Biophysica Acta 1105, 271-277.
40. Ghandour H, Lin BF, Choi SW, Mason JB & Selhub J (2002) Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins. Journal of Nutrition 132, 1357-1360.
41. Giles WH, Kittner SJ, Croft JB, Anda RF, Casper ML & Ford ES (1998) Serum folate and risk for coronary heart disease: results from a cohort of US adults. Annals of Epidemiology 8, 490-496.
42. Giovannucci E (2002) Epidemiologic studies of folate and colorectal neoplasia: a review. Journal of Nutrition 132, 2350S-2355S.
43. Gold M, Chen MF & Johnson K (1995) Plasma and red blood cell thiamine deficiency in patients with dementia of the Alzheimer's type. Archives of Neurology 52, 1081-1086.
44. Gonzalez-Gross M, Marcos A & Pietrzik K (2001) Nutrition and cognitive impairment in the elderly. British Journal of Nutrition 86, 313-321.
45. Gregory JF III (1998) Nutritional properties and significance of vitamin glycosides. Annual Review of Nutrition 18, 277-296.
46. Gregory JF III & Quinlivan EP (2002) In vivo kinetics of folate metabolism. Annual Review of Nutrition 22, 199-220.
47. Haller J (1999) The vitamin status and its adequacy in the elderly: an international overview. International Journal for Vitamin and Nutrition Research 69, 160-168.
48. Hartman TJ, Woodson K, Stolzenberg-Solomon R, Virtamo J, Selhub J, Barrett MJ & Albanes D (2001) Association of the B-vitamins pyridoxal 5'-phosphate (B(6)), B(12), and folate with lung cancer risk in older men. American Journal of Epidemiology 153, 688-694.
49. Heijmans BT, Boer JM, Suchiman HE, Cornelisse CJ, Westendorp RG, Kromhout D, Feskens EJ & Slagboom PE (2003) A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer. Cancer Research 63, 1249-1253.
50. Herrmann W, Quast S, Ullrich M, Schultze H, Bodis M & Geisel J (1999) Hyperhomocysteinemia in high-aged subjects: relation of B-vitamins, folic acid, renal function and the methylenetetrahydrofolate reductase mutation. Atherosclerosis 144, 91-101.
51. Hirsch S, de la Maza P, Barrera G, Gattas V, Petermann M & Bunout D (2002a) The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B-12 deficiency in elderly people. Journal of Nutrition 132, 289-291.
52. Hirsch S, de la Maza P, Mendoza L, Petermann M, Glasinovic A, Paulinelli P, Barrera G, Rosenberg IH & Bunout D (2002b) Endothelial function in healthy younger and older hyperhomocysteinemic subjects. Journal of the American Geriatrics Society 50, 1019-1023.
53. Homocysteine Lowering Trialists' Collaboration (1998) Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. British Medical Journal 316, 894-898.
54. Howard JM, Azen C, Jacobsen DW, Green R & Carmel R (1998) Dietary intake of cobalamin in elderly people who have abnormal serum cobalamin, methylmalonic acid and homocysteine levels. European Journal of Clinical Nutrition 52, 582-587.
55. Huang RF, Hsu YC, Lin HL & Yang FL (2001) Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers. Journal of Nutrition 131, 33-38.
56. Institute of Medicine, National Academy of Sciences (1998) Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline. Washington, DC: National Academy Press. www.iom.edu/
57. Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH & Selhub J (2001) Determinants of plasma total homocysteine concentration in the Framingham offspring cohort. American Journal of Clinical Nutrition 73, 613-621.
58. Jacques PF, Rosenberg IH, Rogers G, Selhub J, Bowman BA, Gunter EW, Wright JD & Johnson CL (1999a) Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey. American Journal of Clinical Nutrition 69, 482-489.
59. Jacques PF, Selhub J, Bostom AG, Wilson PW & Rosenberg IH (1999b) The effect of folic acid fortification on plasma folate and total homocysteine concentrations. New England Journal of Medicine 340, 1449-1454.
60. James SJ, Melnyk S, Pogribna M, Pogribny IP & Caudill MA (2002) Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. Journal of Nutrition 132, 2361S-2366S.
61. Jatoi A, Daly BD, Kramer G & Mason JB (2001) Folate status among patients with non-small cell lung cancer: a case-control study. Journal of Surgery and Oncology 77, 247-252.
62. Jimenez-Jimenez FJ, Molina JA, Hernanz A, Fernandez-Vivancos E, de Bustos F, Barcenilla B, Gomez-Escalonilla C, Zurdo M, Berbel A & Villanueva C (1999) Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease. Neuroscience Letters 271, 33-36.
63. Joshi R, Adhikari S, Patro BS, Chattopadhyay S & Mukherjee T (2001) Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity. Free Radical Biology and Medicine 30, 1390-1399.
64. Kalmijn S, Launer LJ, Lindemans J, Bots ML, Hofman A & Breteler MM (1999) Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study. American Journal of Epidemiology 150, 283-289.
65. Kauwell GP, Lippert BL, Wilsky CE, Herrlinger-Garcia K, Hutson AD, Theriaque DW, Rampersaud GC, Cerda JJ & Bailey LB (2000) Folate status of elderly women following moderate folate depletion responds only to a higher folate intake. Journal of Nutrition 130, 1584-1590.
66. Kesavan V & Noronha JM (1983) Folate malabsorption in aged rats related to low levels of pancreatic folyl conjugase. American Journal of Clinical Nutrition 37, 262-267.
67. Khosraviani K, Weir HP, Hamilton P, Moorehead J & Williamson K (2002) Effect of folate supplementation on mucosal cell proliferation in high risk patients for colon cancer. Gut 51, 195-199.
68. Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ & Schouten EG (2002) MTHFR 677C -→ T polymorphism and risk of coronary heart disease: a meta-analysis. Jama 288, 2023-2031.
69. Konings EJ, Goldbohm RA, Brants HA, Saris WH & Van Den Brandt PA (2002) Intake of dietary folate vitamers and risk of colorectal carcinoma. Cancer 95, 1421-1433.
70. Lamprecht SA & Lipkin M (2003) Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nature Reviews. Cancer 3, 601-614.
71. Lang D, Kredan MB, Moat SJ, Hussain SA, Powell CA, Bellamy MF, Powers HJ & Lewis MJ (2000) Homocysteine-induced inhibition of endothelium-dependent relaxation in rabbit aorta: role for superoxide anions. Arteriosclerosis, Thrombosis and Vascular Biology 20, 422-427.
72. Le Marchand L, Donlon T, Hankin JH, Kolonel LN, Wilkens LR & Seifried A (2002) B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). Cancer Causes and Control 13, 239-248.
73. Lievers KJ, Kluijtmans LA & Blom HJ (2003) Genetics of hyperhomocysteinaemia in cardiovascular disease. Annals of Clinical Biochemistry 40, 46-59.
74. Lindeman RD, Romero LJ, Koehler KM, Liang HC, LaRue A, Baumgartner RN & Garry PJ (2000) Serum vitamin B12, C and folate concentrations in the New Mexico elder health survey: correlations with cognitive and affective functions. Journal of the American College of Nutrition 19, 68-76.
75. Lopez-Sobaler AM, Ortega RM, Quintas ME, Navarro AR, Aparicio A, Gomez-Rodriguez N, Cocho M & Requejo AM (2002) The influence of vitamin B2 intake on the activation coefficient of erythrocyte glutation reductase in the elderly. Journal of Nutrition, Health and Aging 6, 60-62.
76. Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH & Rozen R (1997) Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Research 57, 1098-1102.
77. McKay DL, Perrone G, Rasmussen H, Dallal G & Blumberg JB (2000) Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet. Journal of Nutrition 130, 3090-3096.
78. McKinley MC, McNulty H, McPartlin J, Strain JJ, Pentieva K, Ward M, Weir DG & Scott JM (2001) Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. American Journal of Clinical Nutrition 73, 759-764.
79. McKinley MC, McNulty H, McPartlin J, Strain JJ & Scott JM (2002) Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status. European Journal of Clinical Nutrition 56, 850-856.
80. McNulty H, McKinley MC, Wilson B, McPartlin J, Strain JJ, Weir DG & Scott JM (2002) Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements. American Journal of Clinical Nutrition 76, 436-441.
81. Madigan SM, Tracey F, McNulty H, Eaton-Evans J, Coulter J, McCartney H & Strain JJ (1998) Riboflavin and vitamin B-6 intakes and status and biochemical response to riboflavin supplementation in free-living elderly people. American Journal of Clinical Nutrition 68, 389-395.
82. Malinow MR, Duell PB, Hess DL, Anderson PH, Kruger WD, Phillipson BE, Gluckman RA, Block PC & Upson BM (1998) Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. New England Journal of Medicine 338, 1009-1015.
83. Marshall TA, Stumbo PJ, Warren JJ & Xie XJ (2001) Inadequate nutrient intakes are common and are associated with low diet variety in rural, community-dwelling elderly. Journal of Nutrition 131, 2192-2196.
84. Mason JB (2003) Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism. Journal of Nutrition 133, Suppl. 3, 941S-947S.
85. Mattson MP, Kruman II & Duan W (2002) Folic acid and homocysteine in age-related disease. Ageing Research Reviews 1, 95-111.
86. Maxwell CJ, Hogan DB & Ebly EM (2002) Serum folate levels and subsequent adverse cerebrovascular outcomes in elderly persons. Dementia and Geriatric Cognitive Disorders 13, 225-234.
87. Medrano MJ, Sierra MJ, Almazan J, Olalla MT & Lopez-Abente G (2000) The association of dietary folate, B6, and B12 with cardiovascular mortality in Spain: an ecological analysis. American Journal of Public Health 90, 1636-1638.
88. Meleady R, Ueland PM, Blom H, Whitehead AS, Refsum H, Daly LE, Vollset SE, Donohue C, Giesendorf B, Graham IM, Ulvik A, Zhang Y & Bjorke Monsen AL (2003) Thermolabile methylenetetrahydrofolate reductase, homocysteine, and cardiovascular disease risk: the European Concerted Action Project. American Journal of Clinical Nutrition 77, 63-70.
89. Meltzer HM, Aro A, Andersen NL, Koch B & Alexander I (2003) Risk analysis applied to food fortification. Public Health Nutrition 6, 281-291.
90. Miller JW, Green R, Mungas DM, Reed BR & Jagust WJ (2002) Homocysteine, vitamin B6, and vascular disease in AD patients. Neurology 58, 1471-1475.
91. Miller JW, Green R, Ramos MI, Allen LH, Mungas DM, Jagust WJ & Haan MN (2003) Homocysteine and cognitive function in the Sacramento Area Latino Study on Aging. American Journal of Clinical Nutrition 78, 441-447.
92. Moat SJ, Bonham JR, Cragg RA & Powers HJ (2000) Elevated plasma homocysteine elicits an increase in antioxidant enzyme activity. Free Radical Research 32, 171-179.
93. Moat SJ, Hill MH, McDowell IF, Pullin CH, Ashfield-Watt PA, Clark ZE, Whiting JM, Newcombe RG, Lewis MJ & Powers HJ (2003) Reduction in plasma total homocysteine through increasing folate intake in healthy individuals is not associated with changes in measures of antioxidant activity or oxidant damage. European Journal of Clinical Nutrition 57, 483-489.
94. Nichols HK & Basu TK (1994) Thiamin status of the elderly: dietary intake and thiamin pyrophosphate response. Journal of the American College of Nutrition 13, 57-61.
95. Niculescu MD & Zeisel SH (2002) Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. Journal of Nutrition 132, 2333S-2335S.
96. Nightingale AK, James PP, Morris-Thurgood J, Harrold F, Tong R, Jackson SK, Cockcroft JR & Frenneaux MP (2001) Evidence against oxidative stress as mechanism of endothelial dysfunction in methionine loading model. American Journal of Physiology 280, H1334-H1339.
97. Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, Ueland M & Kvale G (1995) Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. Journal of the American Medical Association 274, 1526-1533.
98. Olivares M, Hertrampf E, Capurro MT & Wegner D (2000) Prevalence of anemia in elderly subjects living at home: role of micronutrient deficiency and inflammation. European Journal of Clinical Nutrition 54, 834-839.
99. Olszewski AJ & McCully KS (1993) Homocysteine metabolism and the oxidative modification of proteins and lipids. Free Radical Biololgy and Medicine 14, 683-693.
100. Platz EA, Giovannucci E, Rimm EB, Rockett HR, Stampfer MJ, Colditz GA & Willett WC (1997) Dietary fiber and distal colorectal adenoma in men. Cancer Epidemiology, Biomarkers and Prevention 6, 661-670.
101. Potter JD (2002) Methyl supply, methyl metabolizing enzymes and colorectal neoplasia. Journal of Nutrition 132, 2410S-2412S.
102. Quinlivan EP, McPartlin J, McNulty H, Ward M, Strain JJ, Weir DG & Scott JM (2002) Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease. Lancet 359, 227-228.
103. Quinn K & Basu TK (1996) Folate and vitamin B12 status of the elderly. European Journal of Clinical Nutrition 50, 340-342.
104. Raghuveer G, Sinkey CA, Chenard C, Stumbo P & Haynes WG (2001) Effect of vitamin E on resistance vessel endothelial dysfunction induced by methionine. American Journal of Cardiology 88, 285-290.
105. Rampersaud GC, Kauwell GP, Hutson AD, Cerda JJ & Bailey LB (2000) Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. American Journal of Clinical Nutrition 72, 998-1003.
106. Ravaglia G, Forti P, Maioli F, Bastagli L, Facchini A, Mariani E, Savarino L, Sassi S, Cucinotta D & Lenaz G (2000) Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged >/=90 y. American Journal of Clinical Nutrition 71, 590-598.
107. Ravaglia G, Forti P, Maioli F, Muscari A, Sacchetti L, Arnone G, Nativio V, Talerico T & Mariani E (2003) Homocysteine and cognitive function in healthy elderly community dwellers in Italy. American Journal of Clinical Nutrition 77, 668-673.
108. Ray JG, Vermeulen MJ, Boss SC & Cole DE (2002) Declining rate of folate insufficiency among adults following increased folic acid food fortification in Canada. Canadian Journal of Public Health 93, 249-253.
109. Robinson K, Arheart K, Refsum H, Brattstrom L, Boers G, Ueland P, Rubba P, Palma-Reis R, Meleady R, Daly L, Witteman J & Graham I (1998) Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC group. Circulation 97,437-443.
110. Rooprai HK, Pratt OE, Shaw GK & Thomson AD (1990) The age dependence of the activity and activation of human red blood cell transketolase. Alcohol and Alcoholism 25, 453-456.
111. Rucker RB (editor) (2001) Handbook of Vitamins, 3rd ed. New York and Basel: Marcel Dekker, Inc.
112. Russell RM (2000) The aging process as a modifier of metabolism. American Journal of Clinical Nutrition 72, 529S-532S.
113. Russell RM, Baik H & Kehayias JJ (2001) Older men and women efficiently absorb vitamin B-12 from milk and fortified bread. Journal of Nutrition 131, 291-293.
114. Savage DG, Lindenbaum J, Stabler SP & Allen RH (1994) Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. American Journal of Medicine 96, 239-246.
115. Saw SM, Yuan JM, Ong CN, Arakawa K, Lee HP, Coetzee GA & Yu MC (2001) Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. American Journal of Clinical Nutrition 73, 232-239.
116. Seekamp A, Hultquist DE & Till GO (1999) Protection by vitamin B2 against oxidant-mediated acute lung injury. Inflammation 23, 449-460.
117. Selhub J, Jacques PF, Wilson PW, Rush D & Rosenberg IH (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. Journal of the American Medical Association 270, 2693-2698.
118. Selley ML, Close DR & Stern SE (2002) The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiology of Aging 23, 383-388.
119. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW & Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. New England Journal of Medicine 346, 476-483.
120. Shannon B, Gnanasampanthan S, Beilby J & Iacopetta B (2002) A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability. Gut 50, 520-524.
121. Shimizu H, Kiyohara Y, Kato I, Tanizaki Y, Ueno H, Kimura Y, Iwamoto H, Kubo M, Arima H, Ibayashi S & Fujishima M (2002) Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction. The Hisayama study. Cerebrovascular Diseases 13, 9-15.
122. Smidt LJ, Cremin FM, Grivetti LE & Clifford AJ (1991) Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency. Journal of Gerontology 46, M16-M22.
123. Stern LL, Mason JB, Selhub J & Choi SW (2000) Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiology, Biomarkers and Prevention 9, 849-853.
124. Stolzenberg-Solomon RZ, Albanes D, Nieto FJ, Hartman TJ, Tangrea JA, Rautalahti M, Sehlub J, Virtamo J & Taylor PR (1999) Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers. Journal of the National Cancer Institute 91, 535-541.
125. Su LJ & Arab L (2001) Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow-up study. Annals of Epidemiology 11, 65-72.
126. Sydow K, Schwedhelm E, Arakawa N, Bode-Boger SM, Tsikas D, Hornig B, Frolich JC & Boger RH (2003) ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins. Cardiovascular Research 57,244-252.
127. Symons JD, Mullick AE, Ensunsa JL, Ma AA & Rutledge JC (2002) Hyperhomocysteinemia evoked by folate depletion: effects on coronary and carotid arterial function. Arteriosclerosis, Thrombosis and Vascular Biology 22, 772-780.
128. Teunissen CE, Blom AH, Van Boxtel MP, Bosma H, de Bruijn C, Jolles J, Wauters BA, Steinbusch HW & de Vente J (2003) Homocysteine: a marker for cognitive performance? A longitudinal follow-up study. Journal of Nutrition, Health and Aging 7, 153-159.
129. Tiemeier H, van Tuijl HR, Hofman A, Meijer J, Kiliaan AJ & Breteler MM (2002) Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. American Journal of Psychiatry 159, 2099-2101.
130. Tucker KL, Rich S, Rosenberg I, Jacques P, Dallal G, Wilson PW & Selhub J (2000) Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring study. American Journal of Clinical Nutrition 71, 514-522.
131. van Asselt DZ, de Groot LC, van Staveren WA, Blom HJ, Wevers RA, Biemond I & Hoefnagels WH (1998) Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. American Journal of Clinical Nutrition 68, 328-334.
132. van Asselt DZ, Pasman JW, van Lier HJ, Vingerhoets DM, Poels PJ, Kuin Y, Blom HJ & Hoefnagels WH (2001) Cobalamin supplementation improves cognitive and cerebral function in older, cobalamin-deficient persons. Journal of Gerontology 56A, M775-M779.
133. van den Berg H (1999) Vitamin B6 status and requirements in older adults. British Journal of Nutrition 81, 175-176.
134. van den Berg H, van der Gaag M & Hendriks H (2002) Influence of lifestyle on vitamin bioavailability. International Journal for Vitamin and Nutrition Research 72, 53-59.
135. van der Wielen RP, Lowik MR, Haller J, van den Berg H, Ferry M & van Staveren WA (1996) Vitamin B-6 malnutrition among elderly Europeans: the SENECA study. Journal of Gerontology 51A, B417-B424.
136. Ventura P, Panini R, Verlato C, Scarpetta G & Salvioli G (2001) Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects. Metabolism 50, 1466-1471.
137. Verhaar MC, Wever RM, Kastelein JJ, van Dam T, Koomans HA & Rabelink TJ (1998) 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 97, 237-241.
138. Voorrips LE, Goldbohn RA, Brants HA, van Poppel GA, Sturmans F, Hermus RV & van den Brandt PA (2000) A prospective cohort study on antioxidant and folate intake and male lung cancer risk. Cancer Epidemiology Biomarkers & Prevention 9, 357-365.
139. Wald DS, Law M & Morris JK (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. British Medical Journal 325, 1202.
140. Wilkinson TJ, Hanger HC, George PM & Sainsbury R (2000) Is thiamine deficiency in elderly people related to age or co-morbidity? Age and Ageing 29, 111-116.
141. Woo KS, Chook P, Chan LL, Cheung AS, Fung WH, Qiao M, Lolin YI, Thomas GN, Sanderson JE, Metreweli C & Celermajer DS (2002) Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation. American Journal of Medicine 112, 535-539.
142. Wright AJ, Finglas PM, Dainby JR, Hart DJ, Wolfe CA, Southon S & Gregory JF (2003) Single oral doses of 13C forms of pteroylmonoglutamic acid and 5-formyltetrahydrofolic acid elicit differences in short-term kinetics of labelled and unlabelled folates in plasma: potential problems in interpretation of folate bioavailability studies. British Journal of Nutrition 90, 363-371.
143. Zhang SM, Willett WC, Selhub J, Hunter DJ, Giovannucci EL, Holmes MD, Colditz GA & Hankinson SE (2003) Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. Journal of the National Cancer Institute 95, 373-380.
144. Zhang X, Li H, Jin H, Ebin Z, Brodsky S & Goligorsky MS (2000) Effects of homocysteine on endothelial nitric oxide production. American Journal of Physiology 279, F671-F678.
145. Ziegler RG, Weinstein SJ & Fears TR (2002) Nutritional and genetic inefficiencies in one-carbon metabolism and cervical cancer risk. Journal of Nutrition 132, 2345S-2349S.