Intracellular liposomes and cholesterol deposits in chronic cholecystitis and biliary sludge

Ultrastructural Pathology

Volumn 28, Issue 3, 2004, Pages 123-136

  Gilloteaux, Jacques ^a,b,c   Miller, Dennis ^b   Louis Morrison, R ^b  

^a SUMMA HEALTH SYSTEM   (United States)

^b American University of the Caribbean School of Medicine   (Netherlands Antilles)

^c American University of the Caribbean School of Medicine   (United States)

Author keywords

Cholecystitis; Cholesterol; Gallbladder; Liposome; Lysosome; Mucus

Indexed keywords

CHOLESTEROL; LIPID; LIPOSOME; MUCIN;

ADULT; AGED; ARTICLE; CELL ORGANELLE; CELL ULTRASTRUCTURE; CHOLELITHIASIS; CHRONIC CHOLECYSTITIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; GALLBLADDER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYSOSOME; MICROVILLUS; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; BILE; CHOLECYSTITIS; CHOLESTEROL; CHRONIC DISEASE; CRYSTALLIZATION; CYTOPLASMIC STRUCTURES; EPITHELIUM; GALLBLADDER; HUMANS; LIPOSOMES; LYSOSOMES; MICROSCOPY, ELECTRON, TRANSMISSION; MICROVILLI; MIDDLE AGED;

EID: 3142621141     PISSN: 01913123     EISSN: None     Source Type: Journal    
DOI: 10.1080/01913120490475888     Document Type: Article

References (70)

1. Gilloteaux J, Pomerants B, Kelly TR. Human gallbladder mucosa ultrastructure: evidence of intraepithelial nerve structures. Am J Anat. 1989; 184:321-333.
2. Oldham-Ott CK, Gilloteaux J. Comparative morphology of the gallbladder and biliary tract in vertebrates: variation in structure, homology in function and gallstones. Microsc Res Tech. 1997; 38:571-597.
3. Gilloteaux J, Karkare S, Kelly TR, Hawkins WS. Ultrastructural aspects of human gallbladder epithelial cells in cholelithiasis: production of anionic mucus. Microsc Res Tech. 1997; 38:643-659.
4. Gilloteaux J, Hawkins WS, Gilloteaux LC, Jasso J, Kelly TR. Ultrastructural aspects of cystic duct epithelium as a result of cholelithiasis and cholesterolosis. Microsc Res Tech. 1997; 39:22-38.
5. Gilloteaux J, Tomasello LM, Elgison DA. Lipid deposits and lipo-mucosomes in human cholecystitis and epithelial metaplasia in chronic cholecystitis. Ultrastruct Pathol. 2003; 27:313-321.
6. Koga A, Todo S, Nishimura M. Electron microscopic observations on the cholesterol distributed in the epithelial cells of the gall bladder. Histochemistry. 1975; 44:303-306.
7. Satoh H, Koga A. Fine structure of cholesterolosis in the human gallbladder and the mechanism of lipid accumulation. Microsc Res Tech. 1997; 39:14-21.
8. Luciano L, Wolpers C. Die Feinstruktur der Gallenblase und der Gallengänge, IV: Die Cholesterose der menschlichen Gallenblasenschleimhaut. Virchows Arch B. 1973; 14: 147-158.
9. Madrid JF, Hernandez F, Ballesta J. Characterization of glycoproteins in the epithelial cells of human and other mammalian gallbladder: a review. Microsc Res Tech. 1997; 38:616-630.
10. Doty JE, Pitt HA, Krachenbecker SL, Porter-Kink V, DenBesten LV. Role of gallbladder mucus in the pathogenesis of gallstones. Am J Surg. 1983; 145:54-61.
11. Hopwood D, Kouroumalis E, Milne G, Bouchier IAD. Cholecystitis: a fine structural analysis. J Pathol. 1980; 130:1-13.
12. English M, Hopwood D. Lipid in the human gallbladder mucosa: a histochemical study by light and electron microscopy. J Pathol. 1985; 146:333-336.
13. Lament JT. Gallbladder mucin glycoprotein hypersecretion in experimental cholelithiasis: role of mucin gel in nucleation of cholesterol gallstones. Adv Exp Med Biol. 1982; 144:231-234.
14. Lament JT, Smith BF, Moore JRL. Role of gallbladder mucin in pathophysiology of gallstones. Hepatology. 1984; 4:51S-56S.
15. Luciano L. Morphological aspects of cholesterol storage in the human gallbladder. In: Cellsand Tissues: A Three-Dimensional Approach by Modern Techniques in Microscopy. New York: Liss; 1989:269-275.
16. Evett RD, Higgins JA, Brown AI Jr. The fine structure of normal mucosa in human gall bladder. Gastroenterology. 1964; 47:49-60.
17. Virchow R. Lieber das Epithel der gallenbläse und über einen intermediären Stoffwechsel des Fettes. Virchows Arch. 1857; 11:574-578.
18. Nevalainen T, Laitio M. Ultrastructure of gall bladder with cholesterosis. Virchows Arch B 1972; 10:237-242.
19. Boyd W. Studies in gall bladder pathology. Br J Surg. 1922; 10:337-356.
20. Togari C, Okada T. The minute structure of the human gallbladder. Okijamas Folio Anat Jpn. 1953; 25:1-12.
21. Kouroumalis E, Ross PE, Clarke A, Hopwood D, Bouchier IAD. Cholesterol esters in gallbladder bile and mucosa from patients with cholecystitis. Clin Chem Acta. 1984; 144:145-154.
22. Neiderhiser DH, Harmon CK, Roth HP. Absorption of cholesterol by the gall bladder. J Lipid Res. 1976; 17:117-124.
23. Neiderhiser DH, Morningstar WA, Roth HP. Absorption of lecithin and lysolecithin by the gall bladder. J Lab Clin Med. 1973; 82:891-897.
24. Neiderhiser DH, Pineda FM, Hejduk LJ, Roth HP. Absorption of oleic acid by the guinea-pig gall bladder. J Lab Clin Med. 1971; 77:985-992.
25. Subbiah MTR, Dickie BA. Presence of cholesterol ester synthetase activity in gallbladder epithelium. Biochem Biophys Res Commun. 1977; 74:1273-1279.
26. Corradini SG, Elisei W, Giovanelli L, et al. Impaired human gallbladder lipid absorption in cholesterol gallstone disease and its effect on cholesterol solubility in bile. Gastroenterology. 2000; 118:912-920.
27. Gilloteaux J, Kosek E, Kelly TR. Sex steroid induction of gallstones in the male Syrian hamster. J Submicrosc Cytol Pathol. 1993; 25:157-172.
28. Gilloteaux J, Kosek E, Kelly TR. Epithelial surface changes and induction of gallstones in the male Syrian hamster gallbladder as a result of a two-month sex steroid treatment. J Submicrosc Cytol Pathol. 1993; 25:519-533.
29. Karkare S, Kelly TR, Gilloteaux J. Morphological aspects of female Syrian hamster gallbladder induced by one-month sex steroid treatment. J Submicrosc Cytol Pathol. 1995; 27: 35-52.
30. Karkare S, Gilloteaux J. Gallstone induced by sex steroids in the female Syrian hamster: duration effects. J Submicrosc Cytol Pathol. 1995; 27:53-74.
31. Ghadially FN. Cell membrane and coat. In: Ghadially FN, ed. Ultrastructural Pathology of the Cell and Matrix, ed 3. London: Butterworths. 1998; 1043-1097.
32. Baglio CM, Farber E. Reversal by adenine of the ethionine-induced lipid accumulation in the endoplasmic reticulum of the rat liver: a preliminary report. J Cell Biol. 1965; 27:591-601.
33. Jennings LJ, Xu QW, Firth TA, Nelson MT, Mawe GM. Cholestrol inhibits spontaneous action potentials and calcium currents in guinea pig gallbladder smooth muscle. Am J Physiol. 1999; 277:G1017-G1026.
34. Walraff J, Dietrich KF. Zur Morphologie und Histochemie der Steingallbläse des Menschen. Z Zellforsch. 1957; 46:155-231.
35. Dingemans KP, Mooi WJ, van den Bergh Weerman MA. Angulate lysosomes. Ultrastruct Pathol. 1983; 5:113-122.
36. Carstens PH, Yacoub O. Importance of angulate bodies in the diagnosis of granular cell tumors (schwannomas). Ultrastruct Pathol. 1993; 17:271-278.
37. Belu D. High-resolution electron microscopy of interlysosomal junctions. Ultrastruct Pathol. 1988; 12:307-316.
38. Karayannopoulou G, Damjanov I. Lectin binding sites in the human gallbladder and cystic duct. Histochemistry. 1987; 88:75-83.
39. Pearson JP, Foster NE. Mucus glycoprotein content of human cholesterol gallstones. Digestion. 1987; 36:132-140.
40. Esterly JR, Spicer SS. Mucin histochemistry of human gall bladder: changes in adenocarcinoma, cystic fibrosis and cholecystitis. 1968; Natl Cancer Inst. 40:1-11.
41. Gilloteaux J, Karkare S, Don AQ, Sexton RC. Cholelithiasis induced in the Syrian hamster: evidence for an intramucinous mucleating process and down regulation of cholesterol 7-alpha hydroxylase (CYP7) gene by medroxyprogesterone. Microsc Res Tech. 1997; 39:56-70.
42. Dive C, Harremans JF. Nature and origin of the proteins of bile, I; a comparative analysis of serum and bile proteins in man. Eur J Clin Invest. 1974; 4:235-239.
43. Kestell MF, Sekijima J, Lee SP, Park Hz, Long M, Kaler EW. A calcium-binding protein in bile and gallstones. Hepatology. 1992; 19:1315-1321.
44. Kaufman HS, Littlemoe KD, Magnuson TH, Frasca P, Pitt HA. Backscattered electron imaging and windowless energy dispersive X-ray microanalysis: a new technique for gallstone analysis. Scanning Microsc. 1990; 4:853-862.
45. Kaufman HS, Magnuson KD, Pitt HA, Frasca P, Littlemoe KD. The distribution of calcium salt precipitates in the core, periphery and the shell of cholesterol, black pigment and brown pigment gallstones. Hepatology. 1994; 19:1124-1132.
46. Carey MC, Small DM. The physical chemistry of cholesterol solubility in bile. J Clin Invest. 1978; 61:988-1026.
47. Baeckstrom D, Karlsson N, Hansson GC. Purification and characterization of sialylle(a)-carrying mucins of human bile; evidence for the presence of MUC1 and MUC3 apoproteins. J Biol Chem. 1994; 269:14430-14437.
48. Klomp LW, de Lely AJ, Strous GJ. Biosynthesis of a human gall-bladder mucin. Biochem J. 1994; 304:737-744.
49. Vandehaute B, Buisine MP, Debailleul V, et al. Mucin gene expression in biliary epithelial cells. J Hepatol. 1997; 27:1057-1066.
50. Sheen PC, Lee KT, Liu YE. Mucin content in gallbladders with brown pigment stones or combination stones with a brown periphery. Digestion. 1998; 59:660-664.
51. Buisine MP, Devisme L, Degand P, et al. Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands, II: duodenum and liver, gallbladder, and pancreas. J Histochem Cytochem. 2000; 48:1667-1676.
52. Ho SB, Shekels LL, Toribara NW, Gipson IK, Purdum PP 3rd, Cherwitz DL. Altered mucin core peptide expression in acute and chronic cholecystitis. Dig Dis Sci. 2000; 45:1061-1071.
53. Lee KT, Liu TS. Mucin gene expression in gallbaldder epithelium with balck pigment stone ascertained by in situ hybridization. Kaohsiung J Med Sci. 2001; 17:517-523.
54. Lee KT, Liu TS. Mucin gene expression in gallbladder epithelium. J Formos Med Assoc. 2002; 101:762-768.
55. Afdhal NH, Miu N, Nunes DP, et al. Mucin-vesicle interactions in model bile: evidence for vesicle aggregation and fusion before cholesterol cyrstal formation. Hepatology. 1995; 22:856-865.
56. Jungst D, Niemeyer A, Muller I, et al. Mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones. World J Gastroenterol. 2001; 7:203-207.
57. Everson GT, Mckinley C, Kern F. Mechanisms of gallstone formation in women: effects of exogenous estrogen (Premarin) and dietary cholesterol on hepatic lipid metabolism. J Clin Invest. 1991; 87:237-246.
58. Cohen S. 1980. The sluggish gallbladder of pregnancy. N Engl J Med. 1980; 302:397-399.
59. Braverman DZ, Johnson ML, Kern F Jr. Effects of pregnancy and contraceptive steroids on gallbladder function. N Engl J Med. 1980; 302:362-364.
60. Everson GT, McKinley C, Lawson M, Johnson M, Kern F Jr. Gallbaldder function and the human female: effects of the ovulatory cycle, pregnancy, and contraceptive pills. Gastroenterologe. 1982; 82:711-719.
61. Shaffer EA, Taylor PJ, Logan K, Gadomski S, Corenblum B. The effect of a progestin on gallbladder function in young women. Am J Obstet Gynecol. 1984; 148:504-507.
62. Qiu Mc, Gilloteaux, J, Kelly TR, Chinag JYL. Regulation of cholesterol 7-ahydroxylase by female sex steroids in Syrian hamsters. FASEB J. 1994; 8:A9-A59.
63. Chiang JYL, Miller WF, Lin GM. Regulation of cholesterol 7α-hydroxylase in the liver. J Biol Chem. 1990; 265:3889-3897.
64. Angelin B. Studies on the regulation of hepatic cholesterol metabolism in humans. Eur J Clin Invest. 1995; 25:215-224.
65. Gilloteaux J, Karkare S, Kelly TR. Apical excrescences in the gallbladder epithelium of the female Syrian hamster in response to medroxyprogesterone. Anat Rec. 1993; 236:479-485.
66. Gerdes MM, Boyden EA. The rate of emptying of human gallblader in pregnancy. Surg Gynecol Obstet. 1938; 66:145-156.
67. Mawe GM. Nerves and hormones interact to control gallbladder function. News Physiol Sci. 1998; 13:84-90.
68. Grozinger KH, Kubica H. Microbiological and histologic correlations in inflammatory gallbladder disease. Immun Infekt. 1980; 8:108-110.
69. Stewart L, Smith AL, Pellegrini CA, Motson RW, Way LW. Pigment gallstones form a composite of bacterial microcolonies and pigment solids. Ann Surg. 1987; 206:242-250.
70. Swidsinski A, Lee SP. The role of bacteria in gallstone pathogenesis. Front Biosci. 2001; 6:E93-E103.