Dermatotoxicity studies of calcipotriol (MC903) ointment - Primary skin irritation, skin sensitization, phototoxicity and skin photosensitization

Journal of Toxicological Sciences

Volumn 21, Issue SUPPL. II, 1996, Pages 475-484

  Suzuki, Toshiro ^a   Kato, Toshihiro ^a   Kitagaki, Tadaharu ^a   Ono, Masahiro ^b   Shirakawa, Kiyomi ^b   Nagata, Mitsuhiro ^b   Konishi, Ryoji ^b  

^a Yazaki Resources Co   (Japan)

^b Teikoku Seiyaku Co   (Japan)

Author keywords

Calcipotriol; MC903 ointment; Phototoxicity; Primary skin irritation; Skin photosensitization (rabbit, guinea pig); Skin sensitization

Indexed keywords

CAVIA; CAVIA PORCELLUS; ORYCTOLAGUS CUNICULUS; SUS SCROFA;

CALCIPOTRIOL; CALCITRIOL; DERMATOLOGICAL AGENT; DRUG DERIVATIVE; IRRITANT AGENT;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CONTACT DERMATITIS; DRUG EFFECT; ERYTHEMA; GUINEA PIG; IMMUNIZATION; IMMUNOLOGY; MALE; OINTMENT; PATHOLOGY; PHOTOSENSITIVITY DISORDER; RABBIT; SKIN;

ANIMALS; CALCITRIOL; DERMATITIS, PHOTOTOXIC; DERMATOLOGIC AGENTS; ERYTHEMA; GUINEA PIGS; IMMUNIZATION; IRRITANTS; MALE; OINTMENTS; PHOTOSENSITIVITY DISORDERS; RABBITS; SKIN;

EID: 3142594119     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.21.supplementii_475     Document Type: Article

References (5)

1. Binderup, L. and Bramm, E. (1988) : Effects of a novel vitamin D analogue MC903 on cell proliferation and differrentiation in vitro and on calcium metabolism in vivo. Biochem. Pharmacol., 37, 889-895.
2. Draize, J. H. (1959) : Appraisal of the safety of chemical in foods, drugs and cosmetics (the Staff of the Division of Pharmacology Food and Drug administration, Department of Health Education and Welfare pub., ed.), p. 46, F.D. A. officials of U.S. Business office, Topeka.
3. Federal Register, 43 (163), 81, Tuesday, Aug. 22 (1978).
4. Magnusson, B. and Kligman, A. M. (1969) : The identification of contact allergens by animal assay. The guinea pig maximization test. J. Invest. Dermatol., 52, 268-276.