Alcohol and Free Radicals;Álcool e radicais livres- Algumas consequêndas; Síntese proteica, disendocrinias, imunidade. Importância do Stress

Acta Medica Portuguesa

Volumn 10, Issue 11, 1997, Pages 809-817

  Manso, Carlos F ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; FREE RADICAL;

ALCOHOLISM; ANIMAL; ENDOCRINE DISEASE; HUMAN; IMMUNOLOGY; METABOLISM; PROTEIN SYNTHESIS; REVIEW; STRESS;

ALCOHOLISM; ANIMALS; ENDOCRINE SYSTEM DISEASES; ETHANOL; FREE RADICALS; HUMANS; PROTEIN BIOSYNTHESIS; STRESS;

EID: 3142590797     PISSN: None     EISSN: 16460758     Source Type: Journal    
DOI: None     Document Type: Article

References (103)

1. MANSO C: O álcool em fisiopatologia. O Médico 1989; 121: 239-48
2. MIRA M, MANSO CF: Àlcool e radicais livres de oxigénio. Acta Med Port 1993; 6: 193-98
3. MANSO C: Patologias relacionadas com o alcoolismo. Acta Med Port 1995; 8: 711-17
4. YOKOYAMA A, TAKAGI T.Cerebral blood flow and metabolic rate in the conscious freely moving rat: the effects of hypercapnia and acute ethanol administration. Alcoholism Clinical Exper Res 1991; 15: 766-70
5. JUCKER B, BARNARD M, SHULMAM M: NMR investigation of the futile cycling of ethanol in chronic alcoholic rats. Alcoholism Clinical Exper Res 1994; 18: 1377-1385
6. MONTOLIU C, GUERRI C: Ethanol increases cytochrome P450 2E1 and induces oxidative stress in astrocytes. J Neurochem 1995; 65: 2561-2570
7. MIRA M, MAIA L, BARREIRA L, MANSO C: Evidence for free radical generation due to NADH oxidation by aldehyde oxidase during ethanol metabolism. Archives Biochem. Biophysics 1995; 318: 53-58
8. SHAW S, JAYATILLEKE E: The role of aldehyde oxidase in ethanol induced hepatic lipid peroxidation in the rat. Biochem J 1990; 268: 579-83
9. MISRA U, HANDLER J, THURMAN R:Chronic ethanol treatment induces hydrogen peroxide production selectively in pericentral regions of the liver lobule. Alcoholism Clin Exper Res 1992; 16: 839-42
10. BONDY S, PEARSON K:Ethanol induced oxidative stress and nutritional status. Alcoholism Clinical Exper Res 1993; 17: 651-54
11. MITCHELL J, KAINEN B:Effects of alcohol on intrauterine oxygen tension in the rat. Alcoholism Clinical Exper Res 1992; 16; 308-310
12. HENDERSON G, DEVI B, SHENKER S:In utero ethanol exposure elicits oxidative stress in the rat fetus. Alcoholism Clinical Exper Res 1995: 19: 714-20
13. PREEDY V, SIDDIQ T, RICHARDSON P: The deleterious effects of alcohol on the heart: involvment of protein turnover. Alcohol and Alcoholism 1994; 29: 141-47
14. KOSKINEN P, KUPARI M: Alcohol and tachicardias. Alcohol and Alcoholism 1991; 26: 199-206
15. SIDDIQ T, RICHARDSON P: Rates of protein synthesis in different regions of the normotensive and hypertrophyed heart in response to acute alcohol toxicity. Alcohol and Alcoholism 1983; 28 : 297-310
16. MARWAY J, PREEDY V:Contractile and non contractile proteins and nucleic acids in stomach, jejunum, ileon, duodenum in response to ethanol. Alcohol and Alcoholism 1991; 26: 549-57
17. MARWAY L, PREEDY V: The acute effects of ethanol and of acetaldehyde on the synthesis of mixed and contractile proteins of the jejunum. Alcohol and Alcoholism 1995; 30: 1995
18. MARWAY L, PREEDY V: Effect of acute ethanol dosage on nucleotide levels in the rat jejunum: relationship to protein synthesis. Alcohol and alcoholism 1993; 28: 521-28
19. PREEDY V, SHERWOOD R, BLACK D: Urinary excretion of the collagen degradation markers pyridinoline and deoxipyridinoline in an experimental rat model of alcoholic bone disease. Alcohol and Alcoholism 1991; 26: 191-98
20. BELL H, BJORNBOE A.Bone collagen, mineral and trace elements composition, histomorphometry and urinary hydroxiproline excretion in chronically treated alcohol fed rats. Alcohol and Alcoholism 1991;26: 39-46
21. PREEDY V, PETERS T: Effects of chronic ethanol consumption and pair feeding on rates of protein synthesis and nucleic acid composition in rat tibia. Alcohol and Alcoholism 1992; 27. 29-37
22. PACY P, PREEDY V, PETERS T: The effect of chronic alcohol consumption on whole body and muscle protein synthesis. A stable isotope study. Alcohol and Alcoholism 1991; 26: 505-13
23. WASSIF W, PREEDY V, SUMMERS B et al: The relationship between muscle fiber atrophy factor, plasma carnosinase and muscle RNA and protein composition in alcoholic myopathy. Alcohol and Alcoholism 1993; 28: 325-31
24. SNYDER A, SINGH S, EHMANN S: Effects of ethanol on DNA, RNA and protein synthesis in rat astrocyte cultuRes Alcoholism Clinical Exper Res 1992; 16: 295-300
25. RILEY E, MATTSON S, SOWELL E et al: Abnormalities of the corpus callosum in children prenatally exposed to alcohol Alcoholism Clinical Exper Res 1995; 19: 1198-202
26. TUMA D, CASEY C, SORREL M: Chronic ethanol induced impairments in receptor mediated endocytosis of insulin in rat hepatocytes. Alcoholism Clinical Exp Res 1991; 13: 808-13
27. WAHL D, GAUCHER P: Relationship of insulin resistance to protein energy malnutrition in patients with alcoholic liver cirrhosis. Alcoholism Clinical Exp Res 1992; 16: 971-78
28. MAUCERI H, UNTERMAN T, DEMPSEY S: Effect of ethanol exposure on circulating levels of insulin like growth factor 1 and 2 and insulin like growth factor binding proteins in fetal rats. Alcoholism Clinical Exper Res 1993;17:1201-06
29. SASAKI Y, HAYASHI N, ITO T: Influence of ethanol on insulin receptor substrate mediated signal transduction during rat liver regeneration. Alcohol and Alcoholism 1994;29, S1 : 99-1106
30. KARL P, FISHER S: Chronic ethanol exposure inhibits insulin and IGF-1 stimulated aminoacid uptake in cultured placental trophoblasts. Alcoholism Clinical Exper Res 1994; 18: 942-46
31. MAUCERI H, LEE W, CONWAY S:Effect of ethanol on insulin like factor 2 release from fetal organs. Alcoholism Clinical Exper Res 1994;18:35-41
32. SRIVASTAVA V, HINEY J, DEES W: Effect of ethanol on the synthesis of insulin like IGF-1 and the IGF-1 receptor in late prepubertal female rats. Alcoholism Clinical Exper Res 1995;19: 1467-73
33. BHAVANY K, MONTE S, BROWN N: Effect of ethanol on p-36 protein kinase substrate and insulin receptor substrate expression and tyrosyl phosphorylation in human hepatocellular carcinoma cells. Alcoholism Clinical Exper Res 1995; 19: 441-46
34. GARBUTT J, HICKS R, CLAYTON C: Behavioral and endocrine interaction between TRH and ethanol in normal human subjects Alcoholism Clinical Exper Res 1991; 15: 1045-49
35. MASON G, NOONAN L, GARBUTT J: Effects of ethanol and control liquid diets on the hypothalamic- pituitary- thyroid axis of male rats. Alcoholism Clinical Exper Res 1992;16: 1130-37
36. GARBUTT J, LOOSEN P: Evidence for normal feedback inhibition of T3 on TSH. Response to TRH in abstinent male alcoholics. Alcoholism Clinical Exper Res 1992; 16: 881-83
37. PIENAAR W, ROBERTS M, EMSLEY R: TRH stimulation test in alcoholism. Alcohol and Alcoholism 1995: 30; 661-67
38. BAUMGARTNER A, OTTO M, PLATZ W: Hypothalamic-pituitary-thyroid axis in chronic alcoholism I. Alcoholism Clinical Exper Res 1994, 18: 284-94
39. BAUMGARTNER A: II Alcoholism Clinical Exper Res 1994; 18: 295-304
40. HANNIGAN J, MARTIER S, NABER J: Independent associations among maternal alcohol consumption and infant thyroxine levels and pregnancy outcomes. Alcoholism Clinical Exper Res 1995; 19: 135-141
41. GARBUTT J, MILLER L, MUNDLE L: Thyrotropin and prolactin responses to TRH in joung men at high or low risk for alcoholism. Alcoholism Clinical Exper Res 1995; 19: 1133-40
42. KORNET M, GOOSEN C, THYSSEN J: Endocrine profile during acquisition of free choice alcohol drinking in rhesus monkeys. Alcohol and Alcoholism 1992; 27. 403-10
43. TRITT S, TIO D, BRAMMER G, TAYLOR A:Adrenalectomy but not adrenal demedulation during pregnancy prevents growth retarding effects of fetal alcohol exposure. Alcoholism Clinical Exper Res 1993; 17: 1281-89
44. RIVIER C: Female rats release more corticosterone than males in response to alcohol. Alcoholism Clinical Exper Res 1993; 17: 854-59
45. WALTMAN C, MCCAUL M, WAND G: Adrenocorticotrophin responses following administration of ethanol and CRH in the sons of alcoholic and control subjects Alcoholism Clinical Exper Res 1994; 18: 826- 30
46. LEE S, RIVIER C: Altered ACTH and Corticosterone responses to IL-1B in male rats exposed to an alcohol diet. Alcoholism Clinical Exper Res 1995; 19: 200-08
47. HIRSCHL M, DERFLER K, BIGLMEYER C:Hormonal derangements in patients with severe alcohol intoxication. Alcoholism Clinical Exper Res 1994; 18: 761-66
48. KORNET M, GOOSEN C, RIBBENS L: The effect of desglycinamide-vasopressin on the acquisition of free choice alcohol drinking in rhesus monkeys. Alcoholism Clinical Exper Res 1991, 15: 72-79
49. GEORGE S, ROLDAN R, NARANJO C: Endogenous opioids are involved in the genetically determined high preference for ethanol consumption. Alcoholism Clinical Exper Res 1991; 15: 668-72
50. ADAMS M, CICERO T: Effects of alcohol on B-endorphin and reproductive hormones in the male rat. Alcoholism Clinical Exper Res 1991; 15: 685-92
51. VESCOVI P, COIRO V, VOLPI R: Plasma B endorphin but not metencephalin are abnormal in alcoholics. Alcohol and Alcoholism 1992; 27. 471-75
52. GIANOULAKIS C, WAELE J: Differences in the brain and pituitary B-endorphin system between the alcohol preferring AA and the alcohol avoiding ANA rats. Alcoholism Clinical Exper Res 1992; 16: 453-459
53. REDDY B, SARKAR D: Effect of alcohol, acetaldehyde and salsolinol on B-endorphin secretion from the hipothalamic neurons in primary cultuRes Alcoholism Clinical Exper Res 1993;17: 1261-67
54. ROSENBLUM E, THIEL D, CAMPBELL I, GAVALER J: Quantitation of B sitosterol in bourbon. Alcoholism Clinical Exper Res 1991; 15: 205-06
55. THIEL DG, TELES A, MONTEIRO E, ROSENBLUM E, CAVALER J: The phytoestrogens present in deethanolized bourbon are biologically active. Alcoholism Clinical Exper Res 1991; 15: 822-23.
56. ROSENBLUM RE, STAUBER R, THIEL, CAMPBELL I, GAVALER J: Assessment of the estrogenic activity of phytoestrogens isolated from bourbon and beer. Alcoholism Clinical Exper Res 1993;17: 1207-09
57. ROSENBLUM E, CAMPBELL I, THIEL D, GAVALER J: Isolaton and identification of phitoestrogens from beer. Alcoholism Clinical Exper Res 1992; 16: 843-45
58. GAVALER J, THIEL J: The association between moderate alcoholic beverage consumption and serum estradiol and testoeterone levels in normal postmenopausal women. Alcoholism Clinical Exper Res 1992; 16: 87-92
59. WESTNEY L, BRUNEY R, ROSS B: Evidence that gonadal hormone levels in amniotic fluid are decreased in males born to alcohol users in humans. Alcohol and Alcoholism 1991 ; 26: 403-407
60. SENGUPTA S, RAY R: Pituitary gonadal functioning in male alcoholics in an indian psychiatric hospital. Alcohol and Alcoholism 1991; 26: 47-51
61. EMANUELE M, TENTLER J, HALLORAN M: The effect of acute in vivo ethanol exposure on FSH transcription and translation. Alcoholism Clinical Exper Res 1992;16, 776-780
62. MCGIVERN R, HANDA R, REDEL E: Decreased postnatal testosterone surge in male rats exposed to ethanol during the last week of gestation. Alcoholism Clinical Exper Res 1993; 17: 1215-22
63. GAVALER J, DEAL S, THIEL D, ARRIA A, ALLAN M: Alcohol and estrogen levels in postmenopausal women. Alcoholism Clinical Exper Res 1993; 17: 786-90
64. KARL P, FISHERS: Ethanol alters hormone production in cultured human placental trophoblasts. Alcoholism Clinical Exper Res 1993,17: 816-21
65. WIMALASENA J, MEEHAN D, DOSTAL R, SILVA M: Selective inhibition of luteinizing hormone action by ethanol in cultured granulosa cells. Alcoholism Clinical Exper Res 1993: 17: 340-44
66. ALFONSO M, DURAN R, MARCO J: Ethanol induced alterations in gonadotrophins secretion during rhe estrous cycle in rats. Alcohol and Alcoholism 1993; 28: 667-74
67. SCOTT H, ZOELLER R, RUDEEN P: Acute prenatal ethanol exposure and luteinizing hormone releasing hormone messenger RNA expression in the fetal mouse brain. Alcoholism Clinical Exper Res 1995,19: 153-59
68. BEKPINAR S, TUGRUL Y: Influence of selenium supplementation in non toxic doses on testis lipid peroxide and antioxidant levels in chronic alcohol fed rats. Alcohol and Alcoholism 1995; 30: 645-50
69. ADAMS M, FORMAN J, CICERO T: Antagonism of alcohol induced suppression of rat testosterone secretion by an inhibitor of nitric oxide syntase. Alcoholism Clinical Exper Res 1993: 17; 660-64
70. ADAMS M, MEYER E, CICERO T: Effects of nitric oxide related agents on alcohol narcosis. Alcoholism Clinical Exper Res 1994; 18. 969-75
71. BLANK S, DUNCAN D, MEADOWS D: Suppression of natural killer cell activity by ethanol consumption and food restriction. Alcoholism clinical Exper Res 1991; 15: 16-22
72. MEADOWS G, WALLENDAL M, KOSUGI A: Ethanol induces marked changes in lymphocyte populations and natural killer cell activity in mice. Alcoholism Clinical Exper Res 1992, 16, 474-79
73. BLANK S, PFISTER L, MEADOWS G: Ethanol induced changes in peripheral Wood and splenic natural killer cells. Alcoholism Clinical Exper Res 1993, 17: 561-65
74. GALLUCCI R, MEADOWS G: Ethanol consumption reduces the cytolytic activity of lymphokine activated killer cells. Alcoholism Clinical Exper Res 1995, 19: 402-09
75. ISAKI L, GORDIS E: Alcohol and immunology - progress and questions. Alcoholism Clinical Exper Res 1993, 17:725-26
76. WATZL B, WATSON R: Role of nutrients in alcohol induced immunomodulation. Alcohol and Alcoholism 1993, 28:89-95
77. KRONFOL Z, HILL E, GREDEN J: Immune function in alcoholism. Alcoholism Clinical Exper Res 1993, 17, 279-83
78. WANG Y, HUANG D, WATSON R: Ethanol induced modulation of cytikine production by splenocytes during murine retrovirus infection causing murine AIDS. Alcoholism Clinical Exper Res 1993, 17: 1035-39
79. WORRAL S, JERSEY J, WILCE P: Antibodies from alcoholics, ethanol fed rats and a rabbit immunized with proteins modified by acetaldehyde in vitro react with liver cytosolic proteins from ethanol fed rats. Alcohol and Alcoholism 1993, 28: 513-19
80. FUKUI H, HIROYUKI K, MORIMURA M: Metabolic fate of endotoxin and TNF in rats with acute and chronic alcohol loading. Alcohol and Alcoholism 1993, 28, S1A, 65-70
81. BASISTA M, GAVALER J, DINDZANS V: Effect of ethanol on Kupfer cell function. Alcoholism Clinical Exper Res 1993, 17556-60
82. SOUZA N, BAUTISTA A, SPITZER J: Acute ethanol intoxication prevents lipopolysaccharide induced down regulation of protein kinase C in rat Kupfer cells. Alcoholism Clinical Exper Res 1992, 16: 64-67
83. GROSSMANN A, ASTLEY S, KENNEDY B: Immune function in offspring of nonhuman primates exposed weekly to ethanol during pregnancy. Alcoholism Clinical Exper Res 1993, 17: 822-27
84. MARTINEZ F, THOMAS N, WATSON R: Interleukin 6 and interleukin 8 production by mononuclear cells of chrome alcoholics during treatment Alcoholism Clinical Exper Res 1993, 17: 1193-97
85. ISHII K, FURUDERA S, KUMASHIRO R:Role of serum Il 8 and adhesion molecule 1 in the severity of alcoholic hepatitis. Alcohol and Alcoholism 1994, 29, supp 1 , 81-85
86. WATSON R, EARNEST D: Alcohol Immunomodulation and disease. Alcohol and Alcoholism 1994. 29: 131-39
87. CHIAPPELLI F, KUNG M, LEE P, VILLANUEVA P: Alcohol modulation of human normal T cell activation, maturation and migration. Alcoholism Clinical Exper Res 1995, 19: 539-44
88. GROSSMAN C, NIENABER M, GARTSIDE P Sex differences and the effects of alcohol on immune response in male and female rats. Alcoholism Clinical Exper Res 1993, 17: 832-40
89. Effect of exposure to an alcohol diet for 10 days on the ability of Il-1B to release ACTH and corticosterone in the adult ovariectomized female rat. Alcoholism Clinical Exper Res 1993, 17: 1009-13
90. RIVIER C: Adult male rats exposed to an alcohol diet exhibit a blunted ACTH response to immune or physical stress: possible role of nitric oxide. Alcohol and Alcoholism Clinical Exper Res 1995, 19: 1474-79
91. LANG C, MOLINA P, ABUMRAD N: Granulocyte Colony stimulating factor prevents ethanol induced impairment in host defense In septic rats. Alcoholism Clinical Exper Res 1993,17: 1268-74
92. ANTONY V, GODBEY S, HOTT J, QUENNER S: Alcohol induced inhibition of alveolar macrophage oxidant release in vivo and in vitro. Alcoholism Clinical Exper Res 1993. 17: 389-93
93. PINA M, TOBIAS A, PINA H: Nonsteroidal inflammatory drugs lower ethanol mediated liver increase in lipids and thiobarbituric acid reactive substances. Alcoholism Clinical Exper Res 1993.17: 1228-3
94. KUROSE I, HIGUCHI H, KATO S: Ethanol induced oxidative stress in the liver. Alcoholism Clinical Exper Res 1996, 20: 77A-85A
95. POTTER J, YANG V, MEZEY E: Regulation of the rat class I alcohol dehydrogenase gene by growth hormone. Biochem Biophys Res Comm 1993, 191, 1040-1045
96. POTTER J, MAC DOUGALD O, MEZEY E: Regulation of rat alcohol dehydrogenase by cyclic AMP in primary hepatocyte culture. Arch Biochem Biophys 1995, 321: 329-35
97. CHIAPPELLI F, GOTTESFELD Z: Symposium on alcohol and T-cell immunity (intrduction). Alcoholism Clinical Experimental Res 1995, 19: 535-38
98. NELSON S, MASON C, SUMMER W Alcohol. Tumor necrosis factor and tuberculosis. Alcoholism Clinical Exper Res 1995, 19. 17-24
99. JERRELLS T, SIBLEY D: Effects of ethanol on cellular immunity to facultative bacteria. Alcoholism Clinical Exper Res 1995, 19: 11-16
100. DEACLUC I, BAGBY G, SPITZER J: Alcohol consumption in rats potenciates the deleterious effect of Gram negative sepsis on hepatic hyaluronan uptake. Alcoholism Clinical Exper Res 1993,17: 1002-08
101. RUIZ A, CALVIN J, GEA F: Tumor necrosis factor, interleukin-1 and interleukin-6 in alcoholic cirrhosis. Alcohol and Alcoholism 1993, 28: 319-323
102. ESKAY R, CHAUTARD T, TORDA T, DAOUD R, HAMELINK C: Alcohol, corticosteroids, energy utilization and hippocampal endangerment. Annals New York Acad. Sc 1995, 171, 105-14
103. STRATAKIS C, CHROUSOS G. Neuroendocrinology and pathophysiology of the stress system. Annals New York Acad Sc 1995, 171: 1-18