Non-invasive urothelial neoplasms: According to the most recent WHO classification

European Urology

Volumn 46, Issue 2, 2004, Pages 170-176

  Lopez Beltran, Antonio ^a   Montironi, Rodolfo ^b  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Bladder cancer; Genetics; Pathology

Indexed keywords

BIOLOGY; CANCER CLASSIFICATION; CANCER GENETICS; CANCER GRADING; CANCER INVASION; CARCINOMA IN SITU; CYSTITIS; DISEASE SEVERITY; DYSPLASIA; GENETIC STABILITY; HUMAN; HYPERPLASIA; INVERTED PAPILLOMA; MOLECULAR MECHANICS; PAPILLARY CARCINOMA; PAPILLOMA; PRIORITY JOURNAL; PROGNOSIS; REACTIVE UROTHELIAL ATYPIA; REVIEW; URINARY TRACT DISEASE; URINARY TRACT TUMOR; UROGENITAL TRACT TUMOR; UROTHELIAL DYSPLASIA; UROTHELIAL HYPERPLASIA; UROTHELIAL PAPILLOMA; VALIDATION PROCESS; WORLD HEALTH ORGANIZATION;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; MALE; MIDDLE AGED; URINARY BLADDER NEOPLASMS; UROTHELIUM; WORLD HEALTH ORGANIZATION;

EID: 3142572803     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2004.03.017     Document Type: Review

References (39)

1. Montironi R., Lopez-Beltran A., Mazzucchelli R., Bostwick D.G. Classification and grading of the non-invasive urothelial neoplasms: recent advances and controversies. J. Clin. Pathol. 56:2003;91-95
2. Montironi R., Scarpelli M., Mazzucchelli R., Hamilton P.W., Thompson D., Ranger-Moore J., et al. Subvisual changes in chromatin organization state are detected by karyometry in the histologically normal urothelium in patients with synchronous papillary carcinoma. Hum. Pathol. 34:2003;893-901
3. Sauter G, Algaba F, Amin M, Busch C, Cheville J, Gasser T, et al. Non-Invasive Urothelial Neoplasias. WHO Classification of Non Invasive Papillary Urothelial Tumors. In: Eble JN, Sauter G, Epstein JI, Sesterhenn I, editors. World Health Organization Classification of Tumors. Pathology and Genetics: Tumors of the Urinary System and Male Genital Organs. Lyon: IARCC Press; 2004.
4. Lopez-Beltran A., Luque R.J., Moreno A., Bollito E., Carmona E., Montironi R. The pagetoid variant of bladder urothelial carcinoma in situ A clinico-pathological study of 11 cases. Virchows Arch. 441:2002;148-153
5. Lopez-Beltran A., Cheng L., Andersson L., Brausi M., de Matteis A., Montironi R., et al. Preneoplastic non-papillary lesions and conditions of the urinary bladder: an update based on the Ancona International Consultation. Virchows Arch. 440:2002;3-11
6. Hartmann A., Moser K., Kriegmair M., Hofstetter A., Hofstaedter F., Knuechel R. Frequent genetic alterations in simple urothelial hyperplasias of the bladder in patients with papillary urothelial carcinoma. Am. J. Pathol. 154:1999;721-727
7. Muto S., Horie S., Takahashi S., Tomita K., Kitamura T. Genetic and epigenetic alterations in normal bladder epithelium in patients with metachronous bladder cancer. Cancer Res. 60:2000;4021-4025
8. Epstein J.I., Amin M.B., Reuter V.R., Mostofi F.K. The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. Am. J. Surg. Pathol. 22:1998;1435-1448
9. Harnden P., Eardley I., Joyce A.D., Southgate J. Cytokeratin 20 as an objective marker of urothelial dysplasia. Br. J. Urol. 78:1996;870-875
10. Hartmann A., Schlake G., Zaak D., Hungerhuber E., Hofstetter A., Hofstaedter F., et al. Occurrence of chromosome 9 and p53 alterations in multifocal dysplasia and carcinoma in situ of human urinary bladder. Cancer Res. 62:2002;809-818
11. Cheng L., Cheville J.C., Neumann R.M., Bostwick D.G. Natural history of urothelial dysplasia of the bladder. Am. J. Surg. Pathol. 23:1999;443-447
12. McKenney J.K., Gomez J.A., Desai S., Lee M.W., Amin M.B. Morphologic expressions of urothelial carcinoma in situ: a detailed evaluation of its histologic patterns with emphasis on carcinoma in situ with microinvasion. Am. J. Surg. Pathol. 25:2001;356-362
13. Helpap B., Kollermann J. Assessment of basal cell status and proliferative patterns in flat and papillary urothelial lesions: a contribution to the new WHO classification of the urothelial tumors of the urinary bladder. Hum. Pathol. 31:2000;745-750
14. Bostwick D.G., Ramnani D., Cheng L. Diagnosis and grading of bladder cancer and associated lesions. Urol. Clin. North Am. 26:1999;493-507
15. Cordon-Cardo C, Cote RJ, Sauter G. Genetic and molecular markers of urothelial premalignancy and malignancy. Scand J Urol Nephrol Suppl 2000:82-93.
16. Waldman FM, Jones PA, Knowles MA, Sidransky D, Cordon-Cardo C, Simon R, et al. Molecular genetics of non invasive urothelial neoplasias. In: Eble JN, Sauter G, Epstein JI, Sesterhenn I, editors. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs. Lyon: IARCC Press; 2004.
17. Stampfer D.S., Carpinito G.A., Rodriguez-Villanueva J., Willsey L.W., Dinney C.P., Grossman H.B., et al. Evaluation of NMP22 in the detection of transitional cell carcinoma of the bladder. J. Urol. 159:1998;394-398
18. McKenney J.K., Amin M.B., Young R.H. Urothelial (transitional cell) papilloma of the urinary bladder: a clinicopathologic study of 26 cases. Mod. Pathol. 16:2003;623-629
19. van Rhijn B.W., Montironi R., Zwarthoff E.C., Jobsis A.C., van der Kwast T.H. Frequent FGFR3 mutations in urothelial papilloma. J. Pathol. 198:2002;245-251
20. Sauter G. Inverted papilloma. WHO Classification of Non-invasive Papillary Urothelial Tumors. In: Eble JN, Sauter G, Epstein JI, Sesterhenn I, editors. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs. Lyon: IARCC Press; 2004.
21. Holmang S., Andius P., Hedelin H., Wester K., Busch C., Johansson S.L. Stage progression in Ta papillary urothelial tumors: relationship to grade, immunohistochemical expression of tumor markers, mitotic frequency and DNA ploidy. J. Urol. 165:2001;1124-1128. discussion 1128-1130
22. Holmang S., Johansson S.L. Stage Ta-T1 bladder cancer: the relationship between findings at first follow-up cystoscopy and subsequent recurrence and progression. J. Urol. 167:2002;1634-1637
23. Cheng L., Neumann R.M., Bostwick D.G. Papillary urothelial neoplasms of low malignant potential. Clinical and biologic implications. Cancer. 86:1999;2102-2108
24. Cheng L., Zhang S., Ulbright T., Bostwick D.G., MacLennan T., Eble J. Genetic analysis of papillary urothelial neoplasm of low malignant potential. Mod. Pathol. 15:2002;158A
25. Fujii Y., Kawakami S., Koga F., Nemoto T., Kihara K. Long-term outcome of bladder papillary urothelial neoplasms of low malignant potential. BJU Int. 92:2003;559-562
26. Desai S., Lim S.D., Jimenez R.E., Chun T., Keane T.E., McKenney J.K., et al. Relationship of cytokeratin 20 and CD44 protein expression with WHO/ISUP grade in pTa and pT1 papillary urothelial neoplasia. Mod. Pathol. 13:2000;1315-1323
27. Alsheikh A., Mohamedali Z., Jones E., Masterson J., Gilks C.B. Comparison of the WHO/ISUP classification and cytokeratin 20 expression in predicting the behavior of low-grade papillary urothelial tumors. World/Health Organization/International Society of Urologic Pathology. Mod. Pathol. 14:2001;267-272
28. Alvarez Kindelan J., Lopez Beltran A., Anglada Curado F., Moreno Arcas P., Carazo J.L., Regueiro Lopez J.C., et al. Clinico-pathologic differences between bladder neoplasm with low malignant potential and low-grade carcinoma. Actas Urol. Esp. 25:2001;645-650
29. Samaratunga H., Makarov D.V., Epstein J.I. Comparison of WHO/ISUP and WHO classification of noninvasive papillary urothelial neoplasms for risk of progression. Urology. 60:2002;315-319
30. Oosterhuis J.W., Schapers R.F., Janssen-Heijnen M.L., Pauwels R.P., Newling D.W., ten Kate F. Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems. J. Clin. Pathol. 55:2002;900-905
31. Pich A., Chiusa L., Formiconi A., Galliano D., Bortolin P., Navone R. Biologic differences between noninvasive papillary urothelial neoplasms of low malignant potential and low-grade (grade 1) papillary carcinomas of the bladder. Am. J. Surg. Pathol. 25:2001;1528-1533
32. Schmitz-Drager B.J., van Roeyen C.R., Grimm M.O., Gerharz C.D., Decken K., Schulz W.A., et al. P53 accumulation in precursor lesions and early stages of bladder cancer. World J. Urol. 12:1994;79-83
33. Richter J., Jiang F., Gorog J.P., Sartorius G., Egenter C., Gasser T.C., et al. Marked genetic differences between stage pTa and stage pT1 papillary bladder cancer detected by comparative genomic hybridization. Cancer Res. 57:1997;2860-2864
34. Richter J., Wagner U., Schraml P., Maurer R., Alund G., Knonagel H., et al. Chromosomal imbalances are associated with a high risk of progression in early invasive (pT1) urinary bladder cancer. Cancer Res. 59:1999;5687-5691
35. Bostwick D.G., Mikuz G. Urothelial papillary (exophytic) neoplasms. Virchows Arch. 441:2002;109-116
36. Busch C., Algaba F. The WHO/ISUP 1998 and WHO 1999 systems for malignancy grading of bladder cancer. Scientific foundation and translation to one another and previous systems. Virchows Arch. 441:2002;105-108
37. Montironi R., Scarpelli M., Sisti S., et al. Quantitative analysis and malignancy progression of the papillary neoplasia of urinary bladder. Pathol. Res. Pract. 182:1987;528-529
38. Lopez-Beltran A., Bassi P.F., Pavone-Macaluso M., Montironi R. Handling and pathology reporting of specimens with carcinoma of the urinary bladder, ureter, and renal pelvis. Eur. Urol. 45:2004;257-266
39. Mostofi FK, Davis CJ, Sesterhenn IA. Histological typing of urinary bladder tumours. World Health Organization, International Histological Classification of Tumours, 2nd ed. Berlin: Springer-Verlag; 1999.