"Honeycomb Golgi" in pituitary adenomas: Not a marker of gonadotroph adenomas

Endocrine Pathology

Volumn 14, Issue 4, 2003, Pages 363-368

  Sano, Toshiaki ^a   Mader, Rene ^b   Asa, Sylvia L ^b   Qian, Zhi Rong ^a   Hino, Akiko ^a   Yamada, Shozo ^c  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF TORONTO   (Canada)

^c TORANOMON HOSPITAL   (Japan)

Author keywords

Corticotroph adenoma; Golgi complex; Gonadotroph adenoma; Nonfunctioning pituitary adenoma; SF 1; Tpit; Vacuolar change

Indexed keywords

GONADOTROPIN; GONADOTROPIN DERIVATIVE; MARKER; TRANSCRIPTION FACTOR;

ADENOHYPOPHYSIS HYPERFUNCTION; ADENOMA; ADULT; AGED; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; FEMALE; GOLGI COMPLEX; HUMAN; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX RATIO; STATISTICAL SIGNIFICANCE;

ADENOMA; ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; DNA-BINDING PROTEINS; FEMALE; FUSHI TARAZU TRANSCRIPTION FACTORS; GOLGI APPARATUS; GONADOTROPINS, PITUITARY; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON; MIDDLE AGED; PITUITARY HORMONES, ANTERIOR; PITUITARY NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; VACUOLES;

EID: 3142517873     PISSN: 10463976     EISSN: None     Source Type: Journal    
DOI: 10.1385/EP:14:4:363     Document Type: Article

References (10)

1. Horvath E, Kovacs K. Gonadotroph adenomas of the human pituitary: sex-related fine-structural dichotomy. A histologic, immunocytochemical, and electron-microscopic study of 30 tumors. Am J Pathol 117:429-440, 1984.
2. Ikeda H, Yoshimoto T, Kovacs K, Horvath E. Cushing's disease due to female gonadotroph adenoma of the pituitary. Clin Endocrinol (Oxford) 43:383-386, 1995.
3. Ikeda H, Yoshimoto T, Ogawa Y, Mizoi K, Murakami O. Clinico-pathological study of Cushing's disease with large pituitary adenoma. Clin Endocrinol (Oxford) 46:669-679, 1997.
4. Sano T, Kovacs K, Asa SL, et al. Pituitary adenoma with "honeycomb Golgi" appearance showing a phenotypic change at recurrence from clinically nonfunctioning to typical Cushing's disease. Endocr Pathol 13:125-130, 2002.
5. Yokoyama S, Kawahara Y, Sano T, Nakayama M, Kitajima S, Kuratsu J. A case of non-functioning pituitary adenoma with Cushing's syndrome upon recurrence. Neuropathology 21:288-293, 2001.
6. Kumar TR, Graham KE, Asa SL, Low MJ. Simian virus 40 T antigen-induced gonadotroph adenomas: a model of human null cell adenomas. Endocrinology 139:3342-3351, 1998.
7. Lamolet B, Pulichino A-M, Lamonerie T, et al. A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with pitx homeoproteins. Cell 104: 849-859, 2001.
8. Kontogeorgos G, Horvath E, Kovacs K. Sex-linked ultrastructural dichotomy of gonadotroph adenomas of the human pituitary: an electron microscopic analysis of 145 tumors. Ultrastruct Pathol 14:475-482, 1990.
9. Zhao L, Bakke M, Krimkevich Y, et al. Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development 128:147-154, 2001.
10. Horvath E. Ultrastructural markers in the pathologic diagnosis of pituitary adenomas. Ultrastruct Pathol 18:171-179, 1994.