Determination of P53 expression in basal cell carcinoma tissues and adjacent nontumoral epidermis from sun-exposed areas of the head and neck

Archives of Iranian Medicine

Volumn 9, Issue 1, 2006, Pages 46-48

  Rajabi, Mohammad Ali ^a   Rajabi, Parvin ^a   Afshar Moghaddam, Noushin ^a  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Basal cell carcinoma; Immunoperoxidase; P53

Indexed keywords

PARAFFIN; PROTEIN P53;

ADULT; AGE DISTRIBUTION; ARTICLE; BASAL CELL CARCINOMA; EPIDERMIS; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPEROXIDASE STAINING; IMMUNOREACTIVITY; IRAN; MAJOR CLINICAL STUDY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE; SUN EXPOSURE;

CARCINOMA, BASAL CELL; EPIDERMIS; GENE EXPRESSION; GENES, P53; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; SUNLIGHT;

EID: 31344467485     PISSN: 10292977     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Rosai J. Skin. In: Rosai J, ed. Rosai and Ackerman's Surgical Pathology. 9th ed. Edinburgh-London: Mosby; 2004: 136-140.
2. Nogita T, Kamikawa T, Kawashima M. Significance of preexistent conditions in basal cell carcinoma on the lower extremities. Int J Dermatol. 1993; 32: 350-353.
3. Kirkham N. Tumors and cysts of the epidermis. In: Elder D, ed. Lever's Histopathology of the Skin. 8th ed. Philadelphia: Lippincott-Raven; 1997: 719-726.
4. Santa-Cruz DJ, Hurt MA. Nonmelanocytic cutaneous tumors. In: Sternberg SS, Antonioli DA, Carter D, Mills SE, Oberman HA, eds. Diagnostic Surgical Pathology. 3rd ed. Philadelphia: Lippincott-Williams and Wilkins; 1999: 57-58.
5. Shea CR, McNutt NS, Volkenandt M, Lugo J, Prioleau PG, Albino AP. Overexpression of P53 protein in basal cell carcinomas of human skin. Am J Pathol. 1992; 141: 25-29.
6. Bayer-Garner IB, Dilday B, Sanderson RD, Smoller BR. Syndecan-1 expression is decreased with increasing aggressiveness of basal cell carcinoma. Am J Dermato Pathol. 2000; 22: 119-122.
7. Ramdial PK, Madarce A, Reddy R, Chetty R. bcl-2 protein expression in a aggressive and nonaggressive basal cell carcinomas. J Cutan Pathol. 2000; 27: 283-291.
8. Auepemkiate S, Boonyaphiphat P, Thongsuksai P. P53 expression related to the aggressive infiltrative histopathological feature of basal cell carcinoma. Histopathology. 2002; 40: 568-573.
9. Neoplasia CR. In: Cotran R. Robins Pathologic Basis of Disease. 6th ed. Phialdelphia: Saunders, 1999: 290-292.
10. Boonchai W, Walsh M, Cummings M, Chenevix-Trench G. Expression of P53 in arsenic-related and sporadic basal cell carcinoma. Arch Dermatol. 2000; 136: 192-198.
11. Vojtesek B, Bartek J, Midgley CA, Lane DP. An immunochemical analysis of the human nuclear phosphoprotein P53. New monoclonal antibodies and epitope mapping using recombinant P53. J Immunol Methods. 1992; 151: 237-244.
12. Rodrigues NR, Rowan A, Smith ME, et al. P53 mutation in colorectal cancer. Proc Natl Acad Sci USA. 1990; 87: 7555-7559.
13. Ecles RA, Warren W, Knee G, et al. Constitutional mutation in exon 8 of the P53 gene in a patient with multiple primary tumors: molecular and immunohistochemical findings. Oncogene. 1993; 8: 69-76.
14. Liang SB, Ohtsuki Y, Furihata M, et al. Sun-exposure and aging-dependent P53 protein accumulation results in growth advantage for tumor cells in carcinogenesis of nonmelanocytic skin cancers. Virchows Arch. 1999; 434: 193-199.
15. Bodak N, Queille S, Avril MF, et al. High levels of patched gene mutations in basal cell carcinomas from patients with xeroderma pigmentosum. Proc Natl Acad Sci USA. 1999; 96: 5117-5122.
16. Soufir N, Basset-Seguin N. Skin carcinogenesis [in French]. Rev Part. 1999; 49: 813-817.
17. Tabata H, Nagano T, Ray AJ, Flanagan N, Birch-MacHin MA, Rees JL. Low frequency of genetic change in P53 immunopositive clones in human epidermis. J Invest Dermatol. 1999; 113: 972-976.
18. Ouhtit A, Nakazawa H, Armstrong BK, et al. UV-radiation-specific P53 mutation frequency in normal skin as a predictor of risk of basal cell carcinoma. J Natl Cancer Inst. 1998; 90: 523-531.