Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure-activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)- N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 5, 2006, Pages 1434-1439

  Middleton, Donald S ^a   Andrews, Mark ^a   Glossop, Paul ^a   Gymer, Geoffrey ^a   Jessiman, Alan ^a   Johnson, Patrick S ^a   MacKenny, Malcolm ^a   Pitcher, Michael J ^a   Rooker, Tony ^a   Stobie, Alan ^a   Tang, Kim ^a,b   Morgan, Paul ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Selective serotonin re uptake inhibitors

Indexed keywords

4 (3,4 DICHLOROPHENYL) N METHYL 1,2,3,4 TETRAHYDRO 1 NAPHTHALENEAMINE DERIVATIVE; FLUOXETINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; METHYLATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; CACO-2 CELLS; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; NAPHTHALENES; RATS; REGIONAL BLOOD FLOW; SENSITIVITY AND SPECIFICITY; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 31344465757     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.031     Document Type: Article

References (10)

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9. Part of this work has been described previously. Middleton, D. S. 230th ACS National Meeting, Washington, DC, Aug 2005; Paper 228.
10. Middleton, D. S.; Stobie, A. EP 1 157 002, 2000.