Effects of a topical α2 adrenergic agonist on ciliary blood flow and aqueous production in rabbits

Experimental Eye Research

Volumn 82, Issue 3, 2006, Pages 405-415

  Reitsamer, H A ^a,b,c   Posey, M ^a   Kiel, J W ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Brimonidine; Episcleral venous pressure; Intraocular pressure homeostasis; Ocular hydrodynamics; Oxygen

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRIMONIDINE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; OXYGEN; QUINOXALINE DERIVATIVE; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; AQUEOUS HUMOR FLOW; AQUEOUS HUMOR FORMATION; ARTICLE; BRADYCARDIA; CAROTID ARTERY FLOW; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; DRUG MECHANISM; EYE BLOOD FLOW; FEMALE; INTRAOCULAR PRESSURE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RABBIT; VENOUS PRESSURE; ANIMAL; AQUEOUS HUMOR; BLOOD; BLOOD FLOW; BLOOD PRESSURE; CILIARY BODY; COMPARATIVE STUDY; CORNEA; HEART RATE; LASER DOPPLER FLOWMETRY; PHYSIOLOGY; TOPICAL DRUG ADMINISTRATION; VASCULARIZATION;

ADMINISTRATION, TOPICAL; ADRENERGIC ALPHA-AGONISTS; ANIMALS; AQUEOUS HUMOR; BLOOD PRESSURE; CILIARY BODY; CORNEA; HEART RATE; INTRAOCULAR PRESSURE; LASER-DOPPLER FLOWMETRY; OXYGEN; QUINOXALINES; RABBITS; REGIONAL BLOOD FLOW; VASOCONSTRICTOR AGENTS;

EID: 31344463531     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2005.07.015     Document Type: Article

References (48)

1. A.A. Acheampong, M. Shackleton, B. John, J. Burke, L. Wheeler, and D. Tang-Liu Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes Drug. Metab. Dispos. 30 2002 421 429
2. A. Alm Ocular circulation W. Hart Adler's Physiology of the Eye 1992 Mosby Year Book St. Louis 198 227
3. A. Bhandari, G.A. Cioffi, E.M. Van Buskirk, S. Orgul, and L. Wang Effect of brimonidine on optic nerve blood flow in rabbits Am. J. Ophthalmol. 128 1999 601 605
4. A. Bill The role of ciliary blood flow and ultrafiltration in aqueous humor formation Exp. Eye Res. 16 1973 287 298
5. R.F. Brubaker Flow of aqueous humor in humans [The Friedenwald Lecture] Invest. Ophthalmol. Vis. Sci. 32 1991 3145 3166
6. J. Burke, C. Crosson, and D. Potter Can UK-14, 304-18 lower IOP in rabbits by a peripheral mechanism? Curr. Eye Res. 8 1989 547 552
7. J. Burke, A. Kharlamb, T. Shan, E. Runde, E. Padillo, C. Manlapaz, and L. Wheeler Adrenergic and imidazoline receptor-mediated responses to UK-14, 304-18 (brimonidine) in rabbits and monkeys. A species difference Ann. N.Y. Acad. Sci. 763 1995 78 95
8. D. Cambridge UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes Eur. J. Pharmacol. 72 1981 413 415
9. C.B. Camras, and L.Z. Bito The pathophysiological effects of nitrogen mustard on the rabbit eye. II. The inhibition of the initial hypertensive phase by capsaicin and the apparent role of substance P Invest. Ophthalmol. Vis. Sci. 19 1980 423 428
10. A.M. Carlsson, B.C. Chauhan, A.A. Lee, and R.P. LeBlanc The effect of brimonidine tartrate on retinal blood flow in patients with ocular hypertension Am. J. Ophthalmol. 129 2000 297 301
11. J. Cepelik, and S. Hynie Inhibitory effects of clonidine and dopamine on adenylate cyclase of rabbit ciliary processes Curr. Eye Res. 9 1990 111 120
12. D.S. Chien, J.J. Homsy, C. Gluchowski, and D.D. Tang-Liu Corneal and conjunctival/scleral penetration of p-aminoclonidine, AGN 190342, and clonidine in rabbit eyes Curr. Eye Res. 9 1990 1051 1059
13. C.E. Crosson, A.R. Heath, G.W. DeVries, and D.E. Potter Pharmacological evidence for heterogeneity of ocular alpha 2 adrenoceptors Curr. Eye Res. 11 1992 963 970
14. R.J. Derick, A.L. Robin, T.R. Walters, H.S. Barnebey, N. Choplin, J. Schuman, E.P. Kelley, K. Chen, and J.F. Stoecker Brimonidine tartrate: a one-month dose response study Ophthalmology 104 1997 131 136
15. R.H. Funk, J. Gehr, and J.W. Rohen Short-term hemodynamic changes in episcleral arteriovenous anastomoses correlate with venous pressure and IOP changes in the albino rabbit Curr. Eye Res. 15 1996 87 93
16. B.T. Gabelt, J.C. Robinson, W.C. Hubbard, C.M. Peterson, N. Debink, A. Wadhwa, and P.L. Kaufman Apraclonidine and brimonidine effects on anterior ocular and cardiovascular physiology in normal and sympathectomized monkeys Exp. Eye Res. 59 1994 633 644
17. S.J. Godwin, C.F. Tortelli, M.L. Parkin, and G.A. Head Comparison of the baroreceptor-heart rate reflex effects of moxonidine, rilmenidine and clonidine in conscious rabbits J. Auton. Neiv. Syst. 72 1998 195 204
18. B.B. Hoffman, and P. Taylor The autonomic and somatic nervous system J. Hardman L. Limbird Goodman and Gilman's The Pharmacological Basis of Therapeutics 2001 McGraw-Hill New York 115 154
19. L. Holm, and M.A. Perry Role of blood flow in gastric acid secretion Am. J. Physiol. 254 1988 G281 G293
20. Y.P. Jarajapu, P. Coats, J.C. McGrath, A. MacDonald, and C. Hillier Increased alpha(1)- and alpha(2)-adrenoceptor-mediated contractile responses of human skeletal muscle resistance arteries in chronic limb ischemia Cardiovasc. Res. 49 2001 218 225
21. Y. Jin, E.E. Elko, T. Tran, and T. Yorio Inhibition of adenylate cyclase in bovine ciliary process and rabbit iris ciliary body to alpha 2-adrenergic agonists J. Ocul. Pharmacol. 5 1989 189 197
22. Y. Jin, A. Verstappen, E. Elko, P. Cammarata, and T. Yorio Effects of lofexidine, an alpha 2-adrenoreceptor agonist, on ocular blood flow and ion transport of rabbit iris-ciliary body J. Ocul. Pharmacol. 8 1992 23 33
23. Y. Jin, A. Verstappen, and T. Yorio Characterization of alpha 2-adrenoceptor binding sites in rabbit ciliary body membranes Invest. Ophthalmol. Vis. Sci. 35 1994 2500 2508
24. D. Kaskel, M. Mergelsberg, H. Rudolf, H. Hubel, N. Wit, U. Edelmann, W. Hunold, U. Metzler, and W. Baumgart Blood flow through different tissues under clonidine in rabbits Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol. 201 1976 149 158
25. P.L. Kaufman, and B.T. Gabelt Alpha-2-adrenergic effects on aqueous humor dynamics J. Glaucoma 4 1995 8 14
26. J.W. Kiel, H.A. Reitsamer, J.S. Walker, and F.W. Kiel Effects of nitric oxide synthase inhibition on ciliary blood flow, aqueous production and intraocular pressure Exp. Eye Res. 73 2001 355 364
27. T. Krupin, P.S. Reinach, O.A. Candia, and S.M. Podos Transepithelial electrical measurements on the isolated rabbit iris-ciliary body Exp. Eye Res. 38 1984 115 123
28. T. Krupin, and P.F. Nichols Active transport and secretiona of aqueous humor S.M. Drance A.H. Neufeld Glaucoma: Applied Pharmacology in Medical Treatment 1984 Grune & Stratton London 71 85
29. Y. Lachkar, C. Migdal, and S. Dhanjil Effect of brimonidine tartrate on ocular hemodynamic measurements Arch. Ophthalmol. 116 1998 1591 1594
30. R.A. Linsenmeier, and C.M. Yancey Improved fabrication of double-barreled recessed cathode O2 microelectrodes J. Appl. Physiol. 63 1987 2554 2557
31. T.W. Mittag, and A. Tormay Drug responses of adenylate cyclase in iris-ciliary body determined by adenine labelling Invest. Ophthalmol. Vis. Sci. 26 1985 396 399
32. J.C. Morrison, M.P. DeFrank, and E.M. Van Buskirk Regional microvascular anatomy of the rabbit ciliary body Invest. Ophthalmol. Vis. Sci. 28 1987 1314 1324
33. A.H. Neufeld, L.M. Jampol, and M.L. Sears Aspirin prevents the disruption of the blood-aqueous barrier in the rabbit eye Nature 238 1972 158 159
34. K. Orito, T. Imaizumi, K. Yoshida, H. Fujiki, M. Kishi, S. Teramoto, M. Tanaka, H. Shimizu, M. Tominaga, Y. Kimura, J. Kambayashi, and T. Mori Mechanisms of action of OPC-28326, a selective hindlimb vasodilator J. Pharmacol. Exp. Ther. 291 1999 604 611
35. H.A. Reitsamer, and J.W. Kiel Effects of dopamine on ciliary blood flow, aqueous production, and intraocular pressure in rabbits Invest. Ophthalmol. Vis. Sci. 43 2002 2697 2703
36. H.A. Reitsamer, and J.W. Kiel A rabbit model to study orbital venous pressure, intraocular pressure, and ocular hemodynamics simultaneously Invest. Ophthalmol. Vis. Sci. 43 2002 3728 3734
37. H.A. Reitsamer, and J.W. Kiel Relationship between ciliary blood flow and aqueous production in rabbits Invest. Ophthalmol. Vis. Sci. 44 2003 3967 3971
38. J.S. Schuman, B. Horwitz, N.T. Choplin, R. David, D. Albracht, and K. Chen A 1-year study of brimonidine twice daily in glaucoma and ocular hypertension. A controlled, randomized, multicenter clinical trial. Chronic brimonidine study group Arch. Ophthalmol. 115 1997 847 852
39. M.L. Sears Miosis and intraocular pressure changes during manometry A.M.A. Arch. Ophthalmol. 63 1960 159 166
40. M.L. Sears Formation of aqueous humor D. Albert F. Jakobiec Principles and Practice in Ophthalmology 1994 W.B. Saunders Philadelphia 182 205
41. M.J. Selbach, U. Schonfelder, and R.H. Funk Arteriovenous anastomoses of the episcleral vasculature in the rabbit and rat eye J. Glaucoma 7 1 1998 50 57
42. J.B. Serle, S. Steidl, R.F. Wang, T.W. Mittag, and S.M. Podos Selective alpha 2-adrenergic agonists B-HI 920 and UK14304-18. Effects on aqueous humor dynamics in monkeys Arch. Ophthalmol. 109 1991 1158 1162
43. A.P. Shepherd, and P.A. Öberg Laser-Doppler Blood Flowmetry 1990 Kluwer Academic Publishers Norwell, MA
44. G.D. Thomas, J. Hansen, and R.G. Victor ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle J. Clin. Invest. 99 1997 2602 2609
45. J.E. Topper, J. McLaren, and R.F. Brubaker Measurement of aqueous humor flow with scanning ocular fluorophotometers Curr. Eye Res. 3 1984 1391 1395
46. C.B. Toris, M.L. Gleason, C.B. Camras, and M.E. Yablonski Effects of brimonidine on aqueous humor dynamics in human eyes Arch. Ophthalmol. 113 1995 1514 1517
47. C.B. Toris, C.B. Camras, and M.E. Yablonski Acute versus chronic effects of brimonidine on aqueous humor dynamics in ocular hypertensive patients Am. J. Ophthalmol. 128 1999 8 14
48. G.L. Zhan, C.B. Toris, M.M. Gaffney, S.P. Durrett, A.J. Toris, C.B. Camras, and M.E. Yablonski Effects of apraclonidine and brimonidine on rabbit ocular blood flow Invest. Ophthalmol. Vis. Sci. 38 1997 (ARVO Abstract No. 3632)