Interstitial cells of cajal in reflux esophagitis: Role in the pathogenesis of the disease

Medical Science Monitor

Volumn 11, Issue 12, 2005, Pages

  Shafik, Ahmed ^a,c   Ahmed, Ismail ^a   El Sibai, Olfat ^b   Shafik, Ali A ^a  

^a CAIRO UNIVERSITY   (Egypt)

^b MENOUFIA UNIVERSITY   (Egypt)

^c NONE   (Egypt)

Author keywords

Action potentials; C kit; Esophagogastric junction; Esophagogastric junction incompetence; Gastroesophageal reflux; Slow waves

Indexed keywords

ANTISERUM; STEM CELL FACTOR RECEPTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GASTROESOPHAGEAL REFLUX; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERSTITIAL CELL OF CAJAL; LOWER ESOPHAGUS SPHINCTER; MALE; MAST CELL; REFLUX ESOPHAGITIS; SMOOTH MUSCLE FIBER;

ADULT; ENDOSCOPY; ESOPHAGITIS, PEPTIC; ESOPHAGOGASTRIC JUNCTION; ESOPHAGUS; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-KIT;

EID: 31344455381     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Korn O, Csendes A, Burdiles P et al: Anatomic dilatation of the cardia and competence of the lower esophageal sphincter: a clinical and experimental study. J Gastrointest Surg, 2000; 4: 398-406
2. Korn O, Stein HJ, Richter T, Liebermann-Meffert D: Gastroesophageal sphincter: a model. Dis Esophagus,1997; 10: 105-9
3. Shafik A, Shafik I, El-Sibai O, Mostafa RM: Does the crural diaphragm share in the contractile activity of the costal diaphragm? The concept of an "autonomous esophageal crus" and its role in esophageal competence. Med Sci Monit, 2004; 10(8): BR268-BR272
4. Kłopocka M, Sinkiewicz A, Budzyński J et al: Improvement in clinical course and laryngeal appearance in selected patients with chronic laryngitis after eight weeks of therapy with rabeprazole. Med Sci Monit, 2004; 10(10): PI115-PI118
5. Brodzicki J, Kamińska B, Radys W, Korzon M: Diagnostic value of methods used in the diagnosis of gastroesophageal reflux disease in children. Med Sci Monit, 2003; 9(Suppl.4): 68-71
6. Eastwood GL, Castell DO, Higgs RH: Experimental esophagitis in cats impairs lower esophageal sphincter pressure. Gastroenterology, 1975; 69: 146-53
7. Timmer R, Breumelhaf R, Nadorp JHSM, Smout AJPM: Esophageal motility and gastroesophageal reflux before and after healing of reflux esophagitis. Gut, 1994; 35: 1519-22
8. Singh P, Taylor RH, Colin-Jones DG: Esophageal motor dysfunction and acid exposure in reflux esophagitis are more severe if Barrett's metaplasia is present. Am J Gastroenterol, 1994; 89: 349-56
9. Buttar NS, Falk GW: Pathogenesis of gastroesophageal reflux and Barrett's esophagus. Mayo Clin Proc, 2001; 76: 226-34
10. Hagger R, Finlayson C, Jeffrey I: Role of the interstitial cells of Cajal in the control of gut motility. Br J Surg, 1997; 84: 445-50
11. Rumessen JJ, Thuneberg L: Pacemaker cells in the gastrointestinal tract: Interstitial cells of Cajal. Scand J Gastroenterol, 1996; 216: 82-94
12. Torihashi S, Ward SM, Nishikawa SI: C-kit dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract. Cell Tissue Res, 1995; 280: 97-111
13. Vanderwinden JM, Rumessen JJ, Bernex F et al: Distribution and ultrastructure of interstitial cells of Cajal in the mouse colon, using antibodies to kit and kit (W-lac Z) mice. Cell Tissue Res, 2000; 2: 155-63
14. Wester T, Eriksson L, Olsson Y, Olsen L: Interstitial cells of Cajal in the human fetal small bowel as shown by C-kit immunohistochemistry. Gut, 1999; 44: 65-71
15. Huizinga JD, Thuneberg L, Kluppel M: C-Kit gene required for interstitial cells of Cajal and for interstitial pacemaker activity. Nature, 1995; 34: 373-74
16. Daniel EE, Posey-Daniel V: Neuromuscular structures in opossum esophagus: role of interstitial cells of Cajal. Am J Physiol, 1984; 246: 305-15
17. Faussone-Pellegrini MS, Cortesini C, Carini M: Interstitial cells of Cajal in the human intestine: two cell populations, two roles? Neurogastroenterol Motil, 1995; 7: 267-80
18. Liu LW, Thuneberg L, Huizinga JD: Selective lesioning of interstitial cells of Cajal by methylene blue and light leads to loss of slow waves. Am J Physiol, 1994; 266: 485-96
19. st ed. New Laser Misr and Golden Press, Cairo, Egypt, 1999; 14-56
20. Shafik A, El-Sibai O, Shafik I, Shafik AA: Electroesophagogram in gastroesophageal reflux disease with a new theory on the pathogenesis of its electric changes. BMC Surgery, 2004; 4: 1-8
21. Shafik A: Electroesophagogram: An experimental study of the electromechanical activity of the esophagus. Dig Surg, 1997; 14: 245-51
22. Daniel EE, Thomas J, Ramnarain M et al: Do gap junctions couple interstitial cells of Cajal pacing and neurotransmission to gastrointestinal smooth muscle? Neurogastroenterol. Motil, 2001; 13: 297-307
23. Mittal PK, Sivri P, Schirmer BD, Heine KI: Effect of crural myotomy on the incidence and mechanism of gastroesophageal reflux in cats. Gastroenterology, 1993; 105: 740-43
24. Shafik A: Recognition of a gastro-esophageal reflex in dogs and its role in lower esophageal sphincter competence. Eur Surg Res, 1998; 30: 352-58