Effects of arginine supplementation on the humoral and innate immune response of older people

European Journal of Clinical Nutrition

Volumn 59, Issue 12, 2005, Pages 1362-1366

  Moriguti, J C ^a   Ferriolli, E ^a   Donadi, E A ^a   Marchini, J S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aged; Arginine; Immune function; Pneumococcal vaccine

Indexed keywords

ARGININE; BACTERIUM ANTIBODY; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; IMMUNOGLOBULIN G; PNEUMOCOCCUS POLYSACCHARIDE; PNEUMOCOCCUS VACCINE;

ADULT; AGED; ANTHROPOMETRY; ANTIBODY TITER; BACTERIAL IMMUNITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG MECHANISM; DRUG POTENTIATION; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMORAL IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOLOGICAL PARAMETERS; INNATE IMMUNITY; LEUKOCYTE MIGRATION; LYMPHOCYTOTOXICITY; MALE; NATURAL KILLER CELL; NEUTROPHIL CHEMOTAXIS; NORMAL HUMAN; PHAGOCYTOSIS; RANDOMIZED CONTROLLED TRIAL; REVIEW; SEROTYPE; STREPTOCOCCUS PNEUMONIAE; VACCINATION;

ADMINISTRATION, ORAL; AGED; AGED, 80 AND OVER; ANTIBODIES, BACTERIAL; ANTIBODY FORMATION; ARGININE; CHEMOTAXIS; COMPLEMENT C3; COMPLEMENT C4; DIETARY SUPPLEMENTS; FEMALE; HUMANS; IMMUNITY, NATURAL; IMMUNOGLOBULIN G; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; PNEUMOCOCCAL VACCINES;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PNEUMONIAE;

EID: 31344444194     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1602247     Document Type: Review

References (27)

1. Alexander JW (2002): Nutritional pharmacology in surgical patients. Am. J. Surg. 183, 349-352.
2. Azzara A, Carulli G, Sbrana S, Rizzuti-Gullaci A, Minnucci S, Natale M & Ambrogi F (1995): Effects of lysine-arginine association on immune functions in patients with recurrent infections. Drugs Exp. Clin. Res. 21, 71-78.
3. Barbul A, Sisto DA, Wasserkrug BA & Efron G (1981): Arginine stimulates lymphocyte immune response in healthy human beings. Surgery 90, 244-250.
4. Bender BS (2003): Infectious disease risk in the elderly. Immunol. Allergy Clin. North Am. 23, 57-64.
5. Brandileone MC, de Andrade AL, Di Fabio JL, Guerra ML & Austrian R (2003): Appropriateness of a pneumococcal conjugate vaccine in Brazil: potential impact of age and clinical diagnosis, with emphasis on meningitis. J. Infect. Dis. 187, 1206-1212.
6. Brittenden J, Park KGM, Heys SD, Ross C, Ashby J, Ah-See AK & Eremin O (1994): L-arginine stimulates host defenses in patients with breast cancer. Surgery 115, 205-212.
7. Bryant J, Day R, Whiteside TL & Herberman RB (1992): Calculation of lytic units for the expression of cell-mediated cytotoxicity. J. Immunol. Methods 146, 91-103.
8. Burns EA (2004): Effects of aging on immune function. J. Nutr. Health Aging 8, 9-18.
9. Corberand J, Ngyen F, Laharrague P, Fontanilles AM, Gleyzes B, Gyrard E & Senegas C (1981): Polymorphonuclear functions and aging in humans. J. Am. Geriatr. Soc. 29, 391-397.
10. Donadi EA & Falcão RP (1987): Neutrophil chemotaxis in sickle cell anaemia, sickle cell β thalassaemia, and after splenectomy. J. Clin. Pathol. 40, 670-672.
11. Efron D & Barbul A (2000): Role of arginine in immunonutrition. J. Gastroenterol. 35, 20-23.
12. Fossel M (2002): Cell senescence in human aging and disease. Ann. NY Acad. Sci. 959, 14-23.
13. Go ES & Ballas ZK (1996): Anti-pneumococcal antibody in normal subjects: a meta-analysis. J. Allergy Clin. Immunol. 98, 205-215.
14. Kirk SJ, Hurson M, Regan MC, Holt DR, Wasserkrug HL, Barbul A, Daly JM & Flye MW (1994): Arginine stimulates wound healing and immune function in elderly human-beings. Surgery 114, 155-160.
15. Koivula I, Stén M, Leinonen M & Makela PH (1997): Clinical efficacy of pneumoccocal vaccine in the elderly: A randomized single-blind population-based trial. Am. J. Med. 103, 281-290.
16. Jackson LA, Neuzil KM, Yu OC, Benson P, Barlow WE, Adams AL, Hanson CA, Mahoney LD, Shay DK & Thompson WW (2003): Effectiveness of pneumococcal polysaccharide vaccine in older adults. N. Engl. J. Med. 348, 1747-1755.
17. Lace JK, Tan JS & Watanakunakorn C (1975): An appraisal of the Nitroblue Tetrazolium Reduction Test. Am. J. Med. 58, 685-694.
18. Lahood N, Emerson S, Kumar P & Sorensen RU (1993): Antibody levels and response to pneumoccocal vaccine in steroid-dependent asthma. Ann. Allergy 70, 289-294.
19. LesouAd B (2004): Nutrition: a major factor influencing immunity in the elderly. J. Nutr. Health Aging 8, 28-37.
20. Muhling J, Fuchs M, Fleck C, Sablotzki A, Krull M, Dehne MG, Gonter J, Weiss S & Engel J (2002): Effects of arginine, L-alanyl-L-glutamine or taurine on neutrophil (PMN) free amino acid profiles and immune function in vitro. Amino Acids 22, 39-53.
21. Nieves Jr C &ALangkamp-Henken B (2002): Arginine and immunity: a unique perspective. Biomed. Pharmacother. 56, 471-482.
22. Provinciali M, Montenovo A, Stefano GD, Colombo M, Daghetta L, Cairati M, Veroni C, Cassino R, Della Torre F & Fabris N (1998): Effect of zinc or zinc plus arginine supplementation on antibody titre and lymphocyte subsets after influenza vaccination in elderly subjects: A randomized controlled trial. Age Age. 7, 715-722.
23. Sankilampi U, Honkanen P, Bloigu A & Leinonen M (1996): Antibody response to pneumococcal capsular polysaccharide vaccine in the elderly. J. Infect. Dis. 173, 387-393.
24. Schueren MAE, Quak JJ, Flier BME, Kuik DJ, Snow GB, Green CJ & Leevwen PAM (2001): Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am. J. Clin. Nutr. 73, 323-332.
25. Suchner U, Heyland DK & Peter K (2002): Immune-modulatory actions of arginine in the critically ill. Br. J. Nutr. 87, 121-132.
26. Urban L, Bessenyei B, Marka M & Semsei I (2002): On the role of aging in the etiology of autoimmunity. Gerontology 48, 179-184.
27. Vannucchi H & Marchini JS (1996): Avaliação do estado nutricional. Medicina 1, 5-18.