Human telomerase reverse transcriptase expression in oral carcinogenesis - A preliminary report

Journal of Experimental and Clinical Cancer Research

Volumn 24, Issue 4, 2005, Pages 639-646

  Kumar, Satish Kumar Shyam ^a   Zain, R B ^a   Ismail, S M ^a   Cheong, S C ^b  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b CANCER RESEARCH INITIATIVES FOUNDATION   (Malaysia)

Author keywords

Human telomerase reverse transcriptase; Immunohistochemistry; Oral precancer; Oral squamous cell carcinoma; Telomerase

Indexed keywords

PARAFFIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; BASAL CELL; CANCER DIAGNOSIS; CANCER STAGING; CARCINOGENESIS; CELL IMMORTALIZATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DYSPLASIA; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; LABELING INDEX; LEUKOPLAKIA; MOUTH CANCER; MOUTH MUCOSA; MOUTH TUMOR; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MOUTH NEOPLASMS; PRECANCEROUS CONDITIONS; TELOMERASE; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 31344441663     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Das B.R., Nagpal J.K.: Understanding the biology of oral cancer. Med. Sci. Monit. 8: 258-267, 2002.
2. Johnson N.W.: Global epidemiology. In: Shah J.P., Johnson N.W., Batsakis J.G., eds. Oral Cancer. London: Martin Dunitz, an imprint of the Taylor & Francis Group, 2003: 3-32.
3. Balaram P., Sridhar H., Rajkumar T. et al.: Oral cancer in southern India: the influence of smoking, drinking, paan-chewing and oral hygiene. Int. J. Cancer 98: 440-445, 2002.
4. International Agency for Research on Cancer (IARC) Press Release No: 149. IARC Monographs Programme Finds Betel-Quid and Areca-Nut Chewing Carcinogenic to Humans, 7 August 2003.
5. Califano J., van der Riet P., Westra W. et al.: Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res. 56: 2488-2492, 1996.
6. Johnson N.W., Ranasinghe A.W., Warnakulasuriya K.: Potentially malignant lesions and conditions of the mouth and oropharynx: natural history- cellular and molecular markers of risk. Eur. J. Cancer Prev. Suppl. 2: 31-51, 1993.
7. Pindborg J.J., Reichart P., Smith C.J. et al.: Precancerous Lesions (Histological classification). In: Pindborg J.J., Reichart P., Smith C.J., et al., eds. WHO-Histological Typing of Cancer and Precancer of the Oral Mucosa. Berlin: Springer-Verlag, 1997: 25-26.
8. Abbey L.M., Kaugars G.E., Gunsolley J.C. et al.: Intraexaminer and interexaminer reliability in the diagnosis of oral epithelial dysplasia. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 80: 188-191, 1995.
9. Karabulut A., Reibel J., Therkildsen M.H., Praetorius F., Nielsen H.W., Dabelsteen E.: Observer variability in the histologic assessment of oral premalignant lesions. J. Oral Pathol. Med. 24: 198-200, 1995.
10. Warnakulasuriya S.: Lack of molecular markers to predict malignant potential of oral precancer. J. Pathol. 190: 407-409, 2000.
11. Kim H.R., Christensen R., Park N.H., Sapp P., Kang M.K.: Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis. Clin. Cancer Res. 7: 3079-3086, 2001.
12. Blackburn E.H.: The molecular structure of centromeres and telomeres. Annu. Rev. Biochem. 53: 163-194, 1984.
13. Greider C.W.: Telomere length regulation. Annu. Rev. Biochem. 65: 337-365, 1996.
14. Reddel R.R.: The role of senescence and immortalization in carcinogenesis. Carcinogenesis 21: 477-484, 2000.
15. Morin G.B.: The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59: 521-529, 1989.
16. Feng J., Funk W.D., Wang S.S. et al.: The RNA component of human telomerase. Science 269: 1236-1241, 1995.
17. Meyerson M., Counter C.M., Eaton E.N. et al.: hEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization. Cell 90: 785-795, 1997.
18. Kim N.W., Piatyszek M.A., Prowse K.R. et al.: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015, 1994.
19. Kim N.W.: Clinical implications of telomerase in cancer. Eur. J. Cancer 33: 781-786, 1997.
20. Shay J.W., Gazdar A.F.: Telomerase in the early detection of cancer. J. Clin. Pathol. 50: 106-109, 1997.
21. Califano J., Ahrendt S.A., Meininger G., Westra W.H., Koch W.M., Sidransky D.: Detection of telomerase activity in oral rinses from head and neck squamous cell carcinoma patients. Cancer Res. 56: 5720-5722, 1996.
22. Hiyama K., Hirai Y., Kyoizumi S. et al.: Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J. Immunol. 155: 3711-3715, 1995.
23. Yasumoto S., Kunimura C., Kikuchi K. et al.: Telomerase activity in normal human epithelial cells. Oncogene 13: 433-439, 1996.
24. Hiyama E., Hiyama K., Yokoyama T., Shay J.W.: Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues. Neoplasia 3: 17-26, 2001.
25. Chang J.T., Chen Y.L., Yang H.T., Chen C.Y., Cheng A.J.: Differential regulation of telomerase activity by six telomerase subunits. Eur. J. Biochem. 269: 3442-3450, 2002.
26. Counter C.M., Meyerson M., Eaton E.N. et al.: Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene 16: 1217-1222, 1998.
27. Weinrich S.L., Pruzan R., Ma L. et al.: Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17: 498-502, 1997.
28. Frost M., Bobak J.B., Gianani R. et al.: Localization of telomerase hTERT protein and hTR in benign mucosa, dysplasia, and squamous cell carcinoma of the cervix. Am. J. Clin. Pathol. 114: 726-734, 2000.
29. Fujimoto R., Kamata N., Yokoyama K. et al.: Expression of telomerase components in oral keratinocytes and squamous cell carcinomas. Oral Oncol. 37: 132-140, 2001.
30. Kawakami Y., Kitamoto M., Nakanishi T. et al.: Immunohistochemical detection of human telomerase reverse transcriptase in human liver tissues. Oncogene 19: 3888-3893, 2000.
31. Lee B.K., Diebel E., Neukam F.W., Wiltfang J., Ries J.: Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer. Int. J. Oncol. 19: 1063-1068, 2001.
32. Poremba C., Scheel C., Hero B. et al.: Telomerase activity and telomerase subunits gene expression patterns in neuroblastoma: a molecular and immunohistochemical study establishing prognostic tools for fresh-frozen and paraffin-embedded tissues. J. Clin. Oncol. 18: 2582-2592, 2000.
33. Shao J.C., Wu J.F., Wang D.B., Qin R., Zhang H.: Relationship between the expression of human telomerase reverse transcriptase gene and cell cycle regulators in gastric cancer and its significance. World J. Gastroenterol. 9: 427-431, 2003.
34. Mao L., El-Naggar A.K., Fan Y.H. et al.: Telomerase activity in head and neck squamous cell carcinoma and adjacent tissues. Cancer Res. 56: 5600-5604, 1996.
35. Mutirangura A., Supiyaphun P., Trirekapan S. et al.: Telomerase activity in oral leukoplakia and head and neck squamous cell carcinoma. Cancer Res. 56: 3530-3533, 1996.
36. Sumida T., Sogawa K., Hamakawa H., Sugita A., Tanioka H., Ueda N.: Detection of telomerase activity in oral lesions. J. Oral Pathol. Med. 27: 111-115, 1998.
37. Nguyen D.C., Parsa B., Close A., Magnusson B., Crowe D.L., Sinha U.K.: Overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in head and neck squamous cell carcinomas. Int. J. Oncol. 22: 1285-1290, 2003.
38. Jordan R.C., Daniels T.E., Greenspan J.S., Regezi J.A.: Advanced diagnostic methods in oral and maxillofacial pathology. Part II: immunohistochemical and immunofluorescent methods. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 93: 56-74, 2002.
39. Liu S.C., Klein-Szanto A.J.: Markers of proliferation in normal and leukoplakic oral epithelia. Oral Oncol. 36: 145-151, 2000.
40. Ten Cate A.R.: Oral Mucosa. In: Ten Cate A.R. ed. Oral Histology- Development, Structure and Function. St. Louis, Mosby, 1998: 351-355.
41. Poremba C., Heine B., Diallo R. et al.: Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR. J. Pathol. 198: 181-189, 2002.
42. Tahara H., Yasui W., Tahara E. et al.: Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections. Oncogene 18: 1561-1567, 1999.
43. Wei R., Younes M.: Immunohistochemical detection of telomerase reverse transcriptase in colorectal adenocarcinoma and benign colonic mucosa. Hum. Pathol. 33: 693-696, 2002.
44. Fujimoto R., Kamata N., Taki M., Yokoyama K., Tomonari M., Nagayama M., Yasumoto S.: Gene expression of telomerase related proteins in human normal oral and ectocervical epithelial cells. Oral Oncol. 39: 445-452, 2003.