Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0] hexylphenyl oxazolidinones

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 5, 2006, Pages 1126-1129

  Renslo, Adam R ^a   Gao, Hongwu ^a   Jaishankar, Priyadarshini ^a   Venkatachalam, Revathy ^a   Gómez, Marcela ^a   Blais, Johanne ^a   Huband, Michael ^a   Vara Prasad, J V N ^a   Gordeev, Mikhail F ^a  

^a PFIZER INC   (United States)

Author keywords

Antibacterials; Oxazolidinone

Indexed keywords

ANTIINFECTIVE AGENT; AZABICYCLO[3.1.0]HEXYLPHENYLOXAZOLIDINONE DERIVATIVE; HETEROCYCLIC COMPOUND; NITROGEN; OXABICYCLO[3.1.0]HEXYLPHENYLOXAZOLIDINONE DERIVATIVE; OXAZOLIDINONE DERIVATIVE; OXYGEN; SULFUR; THIABICYCLO[3.1.0]HEXYLPHENYLOXAZOLIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; ANTI-BACTERIAL AGENTS; AZA COMPOUNDS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; MICE; MOLECULAR CONFORMATION; OXAZOLIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

ANIMALIA; NEGIBACTERIA; POSIBACTERIA;

EID: 31344440353     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.093     Document Type: Article

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