In acute leukemia, the polymorphism -211C>T in the promoter region of the multidrug resistance-associated protein 3 (MRP3) does not determine the expression level of the gene

Pharmacogenetics and Genomics

Volumn 16, Issue 2, 2006, Pages 149-150

  Doerfel, Claus ^a   Rump, Andreas ^b   Sauerbrey, Axel ^c   Gruhn, Bernd ^a   Zintl, Felix ^a   Steinbach, Daniel ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c HELIOS KLINIKUM ERFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 3;

ACUTE LEUKEMIA; CONTROLLED STUDY; DNA ISOLATION; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENOTYPE; HUMAN; LETTER; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION;

EID: 31344436915     PISSN: 17446872     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fpc.0000189802.34339.a4     Document Type: Letter

References (6)

1. Lee YM, Cui Y, Konig J, Risch A, Jager B, Drings P, et al. Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3). Pharmacogenetics 2004; 14:213-223.
2. Lang T, Hitzl M, Burk O, Mornhinweg E, Keil A, Kerb R, et al. Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver. Pharmacogenetics 2004; 14:155-164.
3. Steinbach D, Wittig S, Cario G, Viehmann S, Mueller A, Gruhn B, et al. The multidrug resistance-associated protein 3 (MRP3) is associated with a poor outcome in childhood ALL and may account for the worse prognosis in male patients and T-cell immunophenotype. Blood 2003; 102:4493-4498.
4. Steinbach D, Lengemann J, Voigt A, Hermann J, Zintl F, Sauerbrey A. Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2, MRP3, MRP4, MRP5, and SMRP in childhood acute myeloid leukemia. Clin Cancer Res 2003; 9:1083-1086.
5. Plasschaert SL, de Bont ES, Boezen M, van der Kolk DM, Daenen S, Faber KN, et al. High expression of multidrug resistance-associated proteins predicts prognosis in acute lymphoblastic leukemia in children and adults. Blood 2004; 104: abstract 1178.
6. Benderra Z, Faussat AM, Sayada L, Perrot JY, Tang R, Chaoui D, et al. MRP3, BCRP, and P-glycoprotein activities are prognostic factors in adult acute myeloid leukemia. Clin Cancer Res 2005; 11:7764-7772.