Short-term treatment of spontaneously hypertensive rats with liver growth factor reduces carotid artery fibrosis, improves vascular function, and lowers blood pressure

Cardiovascular Research

Volumn 69, Issue 3, 2006, Pages 764-771

  Somoza, Beatriz ^a   Abderrahim, Fatima ^a   González, José M ^a   Conde, M Victoria ^a   Arribas, Silvia M ^a   Starcher, Barry ^e   Regadera, Javier ^b   Fernández Alfonso, María S ^c   Díaz Gil, Juan J ^d   González, M Carmen ^a  

^a AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^e UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

Arterial fibrosis; Extracellular matrix; Hypertension; Liver growth factor; Vasodilatation

Indexed keywords

ANTIFIBROTIC AGENT; ANTIHYPERTENSIVE AGENT; DESMOSINE; ELASTIN; GROWTH FACTOR; LIVER GROWTH FACTOR; MITOGENIC AGENT; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CAROTID ARTERY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FIBROSIS; HEART FUNCTION; HEMODYNAMICS; HYPERTENSION; ISOMETRICS; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; RECORDING; SHORT COURSE THERAPY;

ACETYLCHOLINE; ANIMALS; BILIRUBIN; CAROTID ARTERIES; CELL COUNT; COLLAGEN; DESMOSINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELASTIN; FIBROSIS; FORSKOLIN; HYPERTENSION; ISOMETRIC CONTRACTION; MALE; MICROSCOPY, CONFOCAL; MITOGENS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NITROPRUSSIDE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SERUM ALBUMIN; TIME FACTORS; VASODILATOR AGENTS;

EID: 31344436599     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2005.08.021     Document Type: Article

References (44)

1. M.E. Safar, and G.M. London The arterial system in human hypertension K.J. Swales Textbook of hypertension 1994 Blackwell Scientific London UK 85 102
2. M.E. Safar, B.I. Levy, and H. Struijker-Boudier Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases Circulation 107 2003 2864 2869
3. M.E. Safar, G.M. London, R. Asmar, and E.D. Frohlich Recent advances on large arteries in hypertension Hypertension 32 1998 156 161
4. G.M. London, and J.N. Cohn Prognostic application of arterial stiffness: task forces Am J Hypertens 15 2002 754 758
5. K. Et-Taouil, M. Safar, and G.E. Plante Mechanisms and consequences of large artery rigidity Can J Physiol Pharmacol 81 2003 205 211
6. W.W. Nichols, and M. McDonalds O'Rourke Blood flow in arteries: theoretical, experimental and clinical principles 4th ed. 1998 Arnold London, UK 54 401
7. M.P. Jacob Extracellular matrix remodeling and matrix metalloproteinases in the vascular wall during ageing and in pathological conditions Biomed Pharmacol 57 2003 195 202
8. S. Boumaza, S.M. Arribas, M. Osborne-Pellegrin, J.C. McGrath, S. Laurent, and P. Lacolley Fenestrations of the carotid internal elastic lamina and structural adaptation in stroke-prone spontaneously hypertensive rats Hypertension 37 2001 1101 1107
9. G. Cohuet, P. Challande, M. Osborne-Pellegrin, S.M. Arribas, A. Dominiczak, and H. Louis Mechanical strength of the isolated carotid artery in SHR Hypertension 38 2001 1167 1171
10. D.M. Lombardi, G.K. Owens, and S. Schwartz Ploidy in mesenteric vessels of aged spontaneously hypertensive and Wistar-Kyoto rats Hypertension 13 1989 475 479
11. J.E. Bishop Regulation of cardiovascular collagen deposition by mechanical forces Mol Med Today 4 1998 69 75
12. J.J. Díaz-Gil, P. Escartín, R. García-Canero, C. Trilla, J.J. Veloso, and G. Sánchez Purification of a liver DNA synthesis promoter from plasma of partially hepatectomized rats Biochem J 234 1986 49 55
13. J.J. Díaz-Gil, J.G. Gavilanes, G. Sánchez, R. García-Cañero, J.M. García-Segura, and L. Santamaría Identification of a liver growth factor as an albumin-bilirubin complex Biochem J 243 1987 443 448
14. J.J. Díaz-Gil, G. Sánchez, C. Trilla, and P. Escartín Identification of biliprotein as a liver growth factor Hepatology 8 1988 484 486
15. J.S. Weiss, A. Gautam, J.J. Lauff, M.W. Sundberg, P. Jatlow, and J.L. Boyer The clinical importance of a protein-bound fraction of serum bilirubin in patients with hyperbilirubinemia N Engl J Med 309 1983 147 150
16. J.J. Díaz Gil, G. Sánchez, L. Santamaría, C. Trilla, P. Esteban, and P. Escartín A liver DNA synthesis promoter induced in rat plasma by injection of dimethylnitrosamine (DMNA) or thioacetamide Br J Cancer 55 1987 599 604
17. J.J. Díaz-Gil, J. Muñoz, A. Albillos, C. Rúa, C. Machín, and R. García-Cañero Improvement in liver fibrosis, functionality and hemodynamics in CCl4-cirrhotic rats after injection of the liver growth factor J Hepatol 30 1999 1065 1072
18. J.J. Díaz-Gil, P.L. Majano, M. López-Cabrera, V. Sánchez-López, C. Rúa, and C. Machín The mitogenic activity of the liver growth factor is mediated by tumor necrosis factor alpha in rat liver J Hepatol 38 2003 598 604
19. T.A. Martin, R. Mansel, and W.G. Jiang Hepatocyte growth factor modulates vascular endothelial-cadherin expression in human endothelial cells Clin Cancer Res 7 2001 734 737
20. J.J. Díaz Gil, C. Rúa, C. Machín, R.M. Cereceda, R. García-Canero, and M. de Foronda Hepatic growth induced by injection of the liver growth factor into normal rats Growth Regul 4 1994 113 122
21. I. Koffi, M.E. Safar, C. Labat, P. Lacolley, A. Beetos, and J.J. Mourad Arterial structural changes with verapamil in spontaneously hypertensive rats Am J Hypertens 12 1999 732 738
22. A.M. Briones, J.M. González, B. Somoza, J. Giraldo, C.J. Daly, and E. Vila Role of elastin in spontaneously hypertensive rat small mesenteric artery remodelling J Physiol 552 2003 185 195
23. D.R. Eyre Cross-linking in collagen and elastin Ann Rev Biochem 53 1984 717 748
24. B. Starcher, and M. Conrad Role for neutrophil elastase in the progression of solar elastase Connect. Tissue Res. 31 1995 133 140
25. B. Starcher A ninhydrin based assay to quantitate total protein content of tissue samples Ann Biochem 292 2001 125 129
26. R. Bravo, B. Somoza, M. Ruiz-Gayo, C. González, L.M. Ruilope, and M.S. Fernández-Alfonso Differential effect of chronic antihypertensive treatment on vascular smooth muscle cell phenotype in spontaneously hypertensive rats Hypertension 37 2001 E4 E10
27. L. Lind, S.O. Granstam, and J. Millgard Endothelium-dependent vasodilation in hypertension: a review Blood Press 9 2000 4 15
28. M.L. Hixon, C. Obejero-Paz, C. Muro-Cacho, M.W. Wagner, E. Millie, and J. Nagy Cks1 mediates vascular smooth muscle cell polyploidization J Biol Chem 276 2000 40434 40442
29. G.K. Owens Control of hypertrophic versus hyperplasic growth of vascular smooth muscle cells Am J Physiol 257 1989 H1755 H1765
30. B. Somoza, C. González, V. Cachofeiro, V. Lahera, and M.S. Fernández-Alfonso Chronic l-arginine treatment reduces vascular smooth muscle cell hypertrophy through cell cycle modifcations in spontaneously hypertensive rats J Hypertens 22 2004 751 758
31. G.K. Owens, M.S. Kumar, and B.R. Wamhoff Molecular regulation of vascular smooth muscle cell differentiation in development and disease Physiol Rev 84 2004 767 801
32. J. Rosenbloom, W.R. Abrams, and R. Mecham Extracellular matrix 4: the elastic fiber FASEB J 7 1993 1208 1218
33. M.P. Jacob, C. Badier-Commander, V. Fontaine, Y. Benazzoug, L. Feldman, and J.B. Michel Extracellular matrix remodeling in the vascular wall Pathol Biol 49 2001 326 332
34. F.W. Keeley, and A. Alatawi Response of aortic elastin synthesis and accumulation to developing hypertension and the inhibitory effect of colchicine on this response Lab Invest 64 1991 499 507
35. J.M. González, A.M. Briones, B. Starcher, M.V. Conde, B. Somoza, and C. Daly Influence of elastin on rat small artery mechanical properties Exp Physiol 90 2005 463 468
36. N.D. Ghinea, D. Alexandru, A. Fixman, D. Popov, M. Hasu, and L. Ghitesco Identification of albumin-binding proteins in capillary endothelial cells J Cell Biol 107 1988 231 239
37. J.E. Schnitzer, A. Sung, R. Horvard, and J. Bravo Preferential interaction of albumin-binding proteins, gp30 and gp18, with conformationally modified albumins J Biol Chem 267 1992 24544 24553
38. R. Stocker, A.N. Glazer, and B.N. Ames Antioxidant activity of albumin-bound bilirubin Proc Natl Acad Sci U S A 84 1987 5918 5922
39. T.W. Wu, D. Carey, J. Wu, and H. Sugiyama The cytoprotective effects of bilirubin and biliverdin on rat hepatocytes and human erythrocytes and the impact of albumin Biochem Cell Biol 69 1991 828 834
40. T.W. Wu, J. Wu, R.K. Li, D. Mickle, and D. Carey Albumin-bound bilirubins protect human ventricular myocytes against oxyradical damage Biochem Cell Biol 69 1991 683 688
41. M.E. Safar, P. Chamiot-Clerc, G. Dagher, and J.F. Renaud Pulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats Hypertension 38 2001 1416 1420
42. A. Benetos, B.I. Levy, P. Lacolley, F. Taillard, M. Duriez, and M.E. Safar Role of angiotensin II and bradykinin on aortic collagen following converting enzyme inhibition in spontaneously hypertensive rats Arterioscler Throm Vasc Biol 17 1997 3196 3201
43. M. Ruiz-Gayo, B. Somoza, R. Bravo, M.S. Fernández-Alfonso, and C. González Chronic losartan treatment decreases angiotensin II-mediated facilitation of noradrenaline release in the caudal artery of spontaneously hypertensive rats Life Sci 67 2000 3153 3162
44. D. Rizzoni, L. Rodella, E. Porteri, R. Rezzani, I. Sleiman, and S. Paiardi Effects of losartan and enalapril at different doses on cardiac and renal interstitial matrix in spontaneously hypertensive rats Clin Exp Hypertens 25 2003 427 441