Effects of ciclosporin and tacrolimus on replication of hepatitis B virus in vitro: A comparative study

National Medical Journal of China

Volumn 86, Issue 2, 2006, Pages 111-115

  Xia, Wei Liang ^a   Xie, Hai Yang ^a   Shen, Yan ^a   Wu, Li Ming ^a   Zhang, Feng ^a   Zheng, Shu Sen ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cyclosporine; Hepatitis B virus; Tacrolimus

Indexed keywords

CYCLOSPORIN A; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; TACROLIMUS; VIRUS DNA;

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HEPG2; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DETERMINATION; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; GROWTH INHIBITION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; SLOT BLOT HYBRIDIZATION; VIRUS REPLICATION;

CELL LINE, TUMOR; CELL SURVIVAL; CYCLOSPORINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; TACROLIMUS; TRANSFECTION; VIRUS REPLICATION;

EID: 31144470948     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Samuel D, Muller R, Alexander G, et al. Liver transplantation in European patients with the hepatitis B surface antigen. N Engl J Med, 1993, 329: 1842-1847.
2. Chinese source. 2005,85:1657-1659.
3. Busuttil RW, Lake JR. Role of tacrolimus in the evolution of liver transplantation. Transplantation, 2004, 77: S44-S51.
4. O'Grady JG, Burroughs A, Hardy P, et al. Tacrolimus versus microemulsified ciclosporin in liver transplantation: the TMC randomized controlled trial. Lancet, 2002, 360: 1119-1125.
5. Wiesner RH. A long-term comparison of tacrolimus (FK506) versus cyclosporine in liver transplantation: a report of the United States FK506 Study Group. Transplantation, 1998, 66: 493-499.
6. Martin P, Busuttil RW, Goldstein RM, et al. Impact of tacrolimus versus cyclosporine in hepatitis C virus-infected liver transplant recipients on recurrent hepatitis: a prospective randomized trial. Liver Transpl, 2004, 10: 1258-1262.
7. Sells MA, Chen ML, Acs G. Production of hepatitis B virus particles in HepG2 cells transfected with cloned hepatitis B virus DNA. Proc Natl Acad Sci, 1987, 84: 1005-1009.
8. Sells MA, Zelent AZ, Shvartsman M, et al. Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions. J Virol, 1988, 62: 2836-2844.
9. Chinese source. 2003, 24:310-312.
10. Platz KP, Mueller AR, Haller GW, et al. Impact of immunosuppression and acute rejection on hepatitis B recurrence. Transplant Proc, 1997, 29: 509-510.
11. Chinese source. 1999, 79:193.
12. Liu J, Farmer JD, Lane WS, et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell, 1991, 66: 807-815.
13. Matsuda S, Koyasu S. Mechanisms of action of cyclosporine. Immunopharmacology, 2000, 47: 119-125.
14. Bouchard MJ, Wang LH, Schneider RJ. Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science, 2001, 294: 2376-2378.
15. Lee YI, Hwang JM, Im JH, et al. Human hepatitis B-X protein alters mitochondrial function and physiology in human liver cells. J Biol Chem, 2004, 279: 15460-15471.
16. Xia WL, Shen Y, Zheng SS. Inhibitory effect of cyclosporine A on hepatitis B virus replication in vitro and its possible mechanisms. Hepatobiliary Pancreat Dis Int, 2005, 4: 18-22.
17. Ganem D, Varmus HE. The molecular biology of the hepatitis B viruses. Annu Rev Biochem, 1987, 56: 651-693.
18. Choo QL, Kuo G, Weiner AJ, et al. Isolation of a cDNA clone derived from a blood-borne non-A, Non-B viral hepatitis genome. Science, 1989, 244: 359-362.