Epitaxial 2D nucleation of the stable polymorphic form of the steroid 7αMNa on the metastable form: Implications for Ostwald's rule of stages

International Journal of Pharmaceutics

Volumn 309, Issue 1-2, 2006, Pages 16-24

  Stoica, C ^a   Verwer, P ^a   Meekes, H ^a   Vlieg, E ^a   Van Hoof, P J C M ^b   Kaspersen, F M ^b  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b NV ORGANON   (Netherlands)

Author keywords

Epitaxial nucleation; Metastable zone; Polymorphism

Indexed keywords

(7ALPHA,17ALPHA) 17 HYDROXY 7 METHYL 19 NOR 17 PREGN 5(10) DN 20 YN 3 ONE; STEROID; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG FORMULATION; DRUG STRUCTURE; DRUG TRANSFORMATION; MICROSCOPY; PRIORITY JOURNAL; RAMAN SPECTROMETRY; THREE DIMENSIONAL IMAGING;

ACETONE; CRYSTALLIZATION; ETHANOL; KINETICS; MICROSCOPY, ELECTRON, SCANNING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PREGNENES; SOLUBILITY; SOLVENTS; SPECTRUM ANALYSIS, RAMAN; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 31144469912     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.10.041     Document Type: Article

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