Antiplatelet and antithrombotic activities of methanol extract of Usnea longissima

Phytotherapy Research

Volumn 19, Issue 12, 2005, Pages 1061-1064

  Lee, Kyung Ae ^a   Kim, Moo Sung ^b  

^a Korea Food Research Institute   (South Korea)

^b Macrocare Tech Ltd   (South Korea)

Author keywords

Antiplatelet; Antithrombosis; Lichen; Usnea longissima

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; COLLAGEN; HEPARIN; METHANOL; PLANT EXTRACT; UNCLASSIFIED DRUG; USNEA LONGISSIMA EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BLEEDING TIME; BLOOD CLOTTING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEATH; FIBRINOLYSIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; LUNG EMBOLISM; MALE; MOUSE; NONHUMAN; PARALYSIS; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; RAT; THROMBIN TIME; THROMBOCYTE AGGREGATION; USNEA; USNEA LONGISSIMA;

ANIMALS; BLEEDING TIME; MALE; MICE; MICE, INBRED ICR; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; THROMBOSIS; USNEA;

ANIMALIA; USNEA; USNEA LONGISSIMA;

EID: 31144467304     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.1791     Document Type: Article

References (17)

1. Antiplatelet Trialist Collaboration. 1994. Collaborative overview of randomised trials of antiplatelet therapy 1: Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients. Br Med J 308: 81-106.
2. AOAC Official Method of Analysis. 1985. 16th edn. Association of Official Analytical Chemists: Washington DC.
3. Astrup T, Mullertz S. 1952. The fibrin plate method for estimating fibrinolytic activity. Arch Biochem Biophys 40: 346-350.
4. Born GVR, Cross MJ. 1963. The aggregation of blood platelet. J Physiol 168: 178-195.
5. Crittenden PD, Porter N. 1991. Lichen forming fungi: potential sources of novel metabolites. Trends Biotechnol 9: 409-414.
6. Davies MJ, Thomas AC. 1985. Plaque fissuring - the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br Heart J 53: 363-373.
7. Dejana E, Callioni A, Quintana A, De Gaetano G. 1979. Bleeding time in laboratory animals. II-A comparison of different assay conditions in rats. Thromb Res 15: 191-197.
8. DiMinno G, Silver MJ. 1983. Mouse antithrombotic assay: a simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcohol. J Pharmacol Exp Ther 225: 57-60.
9. Gorden JL. 1981. Platelets in perspective. In Platelets in Biology and Pathology, Gorden JL (ed.). Elsevier, North-Holland Press: Amsterdam, 1-17.
10. Lee H, Nurden AT, Thomaidis A, Caen JP. 1982. Relationship between fibrinogen binding and the platelet glycoprotein deficiencies in Glanzmann's thrombasthenia type I and type II. Br J Haematol 48: 47-57.
11. Lo HS. 1994. Coloured Icones of Chinese Medicine, Vol II. Guangdong Science and Technology Press: Guangdong, 482.
12. Mallavadhani UV, Sudhakar AVS, Mahapatra A, Narasimhan K, Thirunavokkarasu M, Elix JA. 2004. Phenolic and steroidal constituents of the lichen Usnea longissima. Biochem Syst Ecol 32: 95-97.
13. Muller K. 2001. Pharmaceutically relevant metabolites from lichens. Appl Microbiol Biotechnol 56: 9-16.
14. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM. 1995. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease. Clin Chim Acta 235: 207-219.
15. Richardson DHS. 1988. Medicinal and other economic aspects of lichens. In Handbook of Lichenology, vol 3, Galun M (ed.). CRC Press: Boca Raton, 93-108.
16. Yoshimura I. 1994. Lichen Flora of Japan in Color. Hoikusha Publishing: Osaka, 25-40, 117-123.
17. Yuk DY, Ryu CK, Hong JT et al. 2000. Antithrombotic and antiplatelet activities of 2-chloro-3-[4-(ethylcarboxy)-phenyl]-amino-1,4-naphthoquinone (NQ12), a newly synthesized 1,4-naphthoquinone derivative. Biochem Pharmacol 60: 1001-1008.