Low dose busulfan facilitates chimerism and tolerance in a murine model

Transplant Immunology

Volumn 15, Issue 3, 2006, Pages 199-204

  Anam, Khairul ^a   Black, Alfred T ^b   Hale, Douglas A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b Department of Defense ^*  (United States)

Author keywords

Bone marrow; Chimerism; Sirolimus; Tolerance; Transplantation

Indexed keywords

BUSULFAN; CD4 ANTIGEN; CD8 ANTIGEN; MONOCLONAL ANTIBODY; RAPAMYCIN;

ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHIMERA; CONTROLLED STUDY; DONOR; DRUG EFFECT; DRUG TOLERANCE; FLOW CYTOMETRY; GRAFT SURVIVAL; LOW DRUG DOSE; MALE; MIXED LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; NONMYELOABLATIVE CONDITIONING; PHENOTYPE; PRIORITY JOURNAL; SKIN ALLOGRAFT; SKIN GRAFT; T LYMPHOCYTE;

ANIMALS; BONE MARROW TRANSPLANTATION; BUSULFAN; CLONAL DELETION; GRAFT SURVIVAL; IMMUNE TOLERANCE; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; MYELOABLATIVE AGONISTS; SKIN TRANSPLANTATION; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HOMOLOGOUS;

EID: 31144447883     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2005.09.009     Document Type: Article

References (28)

1. J.M. Main, and R.T. Prehn Successful skin homografts after the administration of high dosage × radiation and homologous bone marrow J Natl Cancer Inst 15 4 1955 1023 1029
2. S. Slavin, S. Strober, Z. Fuks, and H.S. Kaplan Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts J Exp Med 146 1 1977 34 48
3. S.T. Ildstad, and D.H. Sachs Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts Nature 307 5947 1984 168 170
4. Y. Sharabi, and D.H. Sachs Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen J Exp Med 169 2 1989 493 502
5. M.M. Durham, A.W. Bingaman, A.B. Adams, J. Ha, S.Y. Waitze, and T.C. Pearson Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning J Immunol 165 1 2000 1 4
6. D.A. Hale, R. Gottschalk, A. Umemura, T. Maki, and A.P. Monaco Establishment of stable multilineage hematopoietic chimerism and donor-specific tolerance without irradiation Transplantation 69 7 2000 1242 1251
7. K. Anam, E. Akpinar, N. Craighead, A.T. Black, and D.A. Hale Targeted T-cell depletion or CD154 blockade generates mixed hemopoietic chimerism and donor-specific tolerance in mice treated with sirolimus and donor bone marrow Transplantation 78 9 2004 1290 1298
8. R.S. Basch, F.L. Quito, J. Beh, and J.A. Hirst Growth of human hematopoietic cells in immunodeficient mice conditioned with cyclophosphamide and busulfan Stem Cells 15 4 1997 314 323
9. A.P. Monaco, J.J. Gozzo, M.L. Wood, and A. Liegeois Use of low doses of homozygous allogeneic bone marrow cells to induce tolerance with antilymphocyte serum (ALS): tolerance by intraorgan injection Transplant Proc 3 1 1971 680 683
10. R.E. Billingham, L. Brent, and P.B. Medawar The technique of free skin grafting in mammals J Exp Biol 28 1951 385
11. S.A. Bobbio, M.L. Wood, and A.P. Monaco Significant augmentation of specific unresponsiveness by rapamycin in ALS-treated, bone marrow injected mice Transplant Sci 3 1993 51
12. R.E. Billingham, L. Brent, and P.B. Medawar Actively acquired tolerance of foreign cells Nature 172 4379 1953 603 606
13. J.M. Main, and R.T. Prehn Fate of skin homografts in X-irradiated mice treated with homologous marrow J Natl Cancer Inst 19 6 1957 1053 1064
14. L.H. Buhler, T.R. Spitzer, M. Sykes, D.H. Sachs, F.L. Delmonico, and N. Tolkoff-Rubin Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease Transplantation 74 10 2002 1405 1409
15. T. Kawai, A.B. Cosimi, R.B. Colvin, J. Powelson, J. Eason, and T. Kozlowski Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys Transplantation 59 2 1995 256 262
16. M. Sykes, G.L. Szot, K.A. Swenson, and D.A. Pearson Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning Nat Med 3 7 1997 783 787
17. D.A. Hale, R. Gottschalk, A. Umemura, T. Maki, and A.P. Monaco Establishment of stable multilineage hematopoietic chimerism and donor-specific tolerance without irradiation Transplantation 69 7 2000 1242 1251
18. T. Wekerle, J. Kurtz, M. Sayegh, H. Ito, A. Wells, and S. Bensinger Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death J Immunol 166 4 2001 2311 2316
19. M.M. Durham, A.W. Bingaman, A.B. Adams, J. Ha, S.Y. Waitze, and T.C. Pearson Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning J Immunol 165 1 2000 1 4
20. E. Seung, J.P. Mordes, A.A. Rossini, and D.L. Greiner Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning J Clin Invest 112 5 2003 795 808
21. L.H. Buhler, T.R. Spitzer, M. Sykes, D.H. Sachs, F.L. Delmonico, and N. Tolkoff-Rubin Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease Transplantation 74 10 2002 1405 1409
22. M. Kimikawa, T. Kawai, D.H. Sachs, R.B. Colvin, A. Bartholomew, and A.B. Cosimi Mixed chimerism and transplantation tolerance induced by a nonlethal preparative regimen in cynomolgus monkeys Transplant Proc 29 1-2 1997 1218
23. Y. Sharabi, V.S. Abraham, M. Sykes, and D.H. Sachs Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance Bone Marrow Transplant 9 3 1992 191 197
24. A.B. Adams, M.M. Durham, L. Kean, N. Shirasugi, J. Ha, and M.A. Williams Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression J Immunol 167 2 2001 1103 1111
25. F. Baron, J.E. Baker, R. Storb, T.A. Gooley, B.M. Sandmaier, and M.B. Maris Kinetics of engraftment in patients with hematological malignancies given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning Blood 104 8 2004 2254 2262 (Jun 29)
26. D.A. Hale, R. Gottschalk, A. Umemura, T. Maki, and A.P. Monaco Immunologic mechanisms in tolerance produced in mice with nonradiation-based lymphoablation and donor-specific bone marrow Transplantation 74 4 2002 477 484
27. J.O. Manilay, D.A. Pearson, J.J. Sergio, K.G. Swenson, and M. Sykes Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimen Transplantation 66 1 1998 96 102
28. T. Wekerle, P. Blaha, Z. Koporc, S. Bigenzahn, M. Pusch, and F. Muehlbacher Mechanisms of tolerance induction through the transplantation of donor hematopoietic stem cells: central versus peripheral tolerance Transplantation 75 9 Suppl 2003 21S 25S