Effects of Gingko biloba extract on gap junction changes induced by reperfusion/reoxygenation after ischemia/hypoxia in rat brain

American Journal of Chinese Medicine

Volumn 33, Issue 6, 2005, Pages 923-934

  Li, Zhen ^a   Lin, Xian Ming ^a   Gong, Pei Li ^a   Zeng, Fan Dian ^a   Du, Guan Hua ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Connexin 43; Gap junction intercellular communication; Gingko biloba extract; Hypoxia reoxygenation; Ischemia reperfusion

Indexed keywords

CONNEXIN 43; GINKGO BILOBA EXTRACT; MESSENGER RNA; NIMODIPINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN HYPOXIA; BRAIN ISCHEMIA; CELL COMMUNICATION; CONTROLLED STUDY; DRUG MECHANISM; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GAP JUNCTION; HIPPOCAMPUS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; REOXYGENATION; REPERFUSION INJURY;

ANIMALS; ASTROCYTES; BRAIN ISCHEMIA; CELL COMMUNICATION; CELLS, CULTURED; CONNEXIN 43; GAP JUNCTIONS; GINKGO BILOBA; INJECTIONS, INTRAPERITONEAL; MALE; NIMODIPINE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA, MESSENGER; VASODILATOR AGENTS;

EID: 31144447355     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X05003430     Document Type: Article

References (32)

1. Alvarez-Maubecin, V., F. Garcia-Hernandez, J.T. Williams and E.J.V. Bockstaele. Functional coupling between neurons and glia. J. Neurosci. 20: 4091-4098, 2000.
2. Barkats, M., P. Venault, Y. Christen and C. Cohen-Salmon. Effect of long-term treatment with EGb 761 on age-dependent structural changes in the hippocampi of three inbred mouse strains. Life Sci. 156: 213-222, 1995.
3. Bennett, M.V., L.C. Barrio, T.A. Bargiello, D.C. Spray, E. Hertzberg and J.C. Saez. Gap junctions: New tools, new answers, new questions. Neuron 6: 305-320, 1991.
4. Beyer, E.C., D.L. Paul and D.A. Goodenough. Connexin 43: A protein from rat heart homologous to a gap junction protein from liver. J. Cell Biol. 105: 2621-2629, 1987.
5. 2+ homeostasis and cell death. J. Neurochem. 70: 958-970, 1998.
6. Bruzzone, R. and C. Giaume. Connexins and information transfer through glia. In: R. Matsas and M. Tsacopoulos (eds.). The Functional Roles of Glial Cells in Health and Disease. Kluwer Academic/Plenum Publishers, New York, 1999, pp. 321-337.
7. Clostre, F. Ginkgo biloba extract (EGb 761): State of knowledge in the dawn of the year 2000. Ann. Pharm. Fr. 57(Suppl. 1): 1S8-88, 1999.
8. Dermietzel, R., E.L. Hertzberg, J.A. Kessler and D.C. Spray. Gap junctions between cultured astrocytes: Immunicytochemical, molecular, and electrophysiological analysis. J. Neurosci. 11: 1421-1432, 1991.
9. Desagher, S., J. Glowinski and J. Premont. Astrocytes protect neurons from hydrogen peroxide toxicity. J. Neurosci. 16: 2553-2562, 1996.
10. Eckenstein, F.P. Fibroblast growth factors in the nervous system. J. Neurobiol. 25: 1467-1480, 1994.
11. Giaume, C. and K.D. McCarthy. Control of junctional communication in astrocytic networks. Trends Neurosci. 19: 319-325, 1996.
12. Goldberg, W.J., J.R. Connor and J.J. Bernstein. Glial fibrillary acidic protein immuno histochemistry of spinal cord astrocytes after induction of ischemia or anoxia in culture. J. Neurosci. Res. 17: 168-175, 1987.
13. Hossain, M.Z., J. Peeling, G.R. Sutherland, E.L. Hertzberg and J.I. Nagy. Ischemia-induced cellular redistribution of the astrocytic gap junctional protein connexin 43 in rat brain. Brain Res. 652: 311-322, 1994.
14. Ichihara, S., Y. Tsuda, N. Hosomi, M. Kitadai and H. Matsuo. Nimodipine improves brain energy metabolism and blood rheology during ischemia and reperfusion in gerbil brain. J. Neurol. Sci. 144: 84-90, 1996.
15. Li, W.E. and J.I. Nagy. Connexin 43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition. Eur. J. Neurosci. 12: 2644-2670, 2000.
16. Lin, J.H., H. Weigel, M.L. Cotrina, S. Liu, E. Bueno and A.J. Hansen. Gap junction-mediated propagation and amplification of cell injury. Nat. Neurosci. 1: 494-500, 1998.
17. Longa, E.Z., P.R. Weinstein, S. Carlson and R. Cummins. Reversible middle cerebral artery occlusion without cranieetomy in rats. Stroke 20: 84-91, 1989.
18. Martínez, A.D. and J.C. Sáez. Regulation of astrocyte gap junctions by hypoxia-reoxygenation. Brain Res. Rev. 32: 250-258, 2000.
19. Nagasawa, H. and K. Kogure. Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion. Stroke 20: 1037-1043, 1989.
20. Nakase, T., S. Fushiki and C. Naus. Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia. Stroke 34: 1987-1993, 2003.
21. Naus, C.C.G., J.F. Bechberger, Y.C. Zhang, L. Venance, H. Yamasaki, S.C. Juneja, G.M. Kidder and C. Giaume. Altered gap junctional communication, intercellular signaling and growth in cultured astrocytes deficient in connexin 43. J. Neurosci. Res. 49: 528-540, 1997.
22. Naus, C.C.G., M.A. Ozog, J.F. Bechberger and T. Nakase. A neuroprotective role for gap junctions. Cell Commun. Adhes. 8: 325-328, 2001.
23. Nudel, U., R. Zakut and M. Shani. The nucleotide sequence of the rat cytoplasmic b-actin gene. Nucleic Acids Res. 5: 1759-1771, 1983.
24. Ozog, M.A., R. Siushansian and C.C.G. Naus. Blocking gap junctions increases glutamate cytotoxicity. J. Neuropathol. Exp. Neurol. 61: 132-141, 2002.
25. Rodriguez, T.E.B., M.T. Droy-Lefaix and N.G. Bazan. Decreased electroconvulsive shock-induced diacylglycerols and free fatty acid accumulation in the rat brain by Ginkgo biloba extract (EGb 761): selective effect in hippocampus as compared with cerebral cortex. J. Neurochem. 61: 1438-1444, 1993.
26. Rouach, N., C.F. Calvo, J. Glowinski and C. Giaume. Brain macrophages inhibit gap junctional communication and down-regulate connexin 43 expression in cultured astrocytes. Eur. J. Neurosci. 15: 403-407, 2002.
27. Sakamoto, A., S.T. Ohnishi and R. Ogawa. Inhibition of lipid peroxidation by some dihydropyridine derivatives. J. Anesth. 7: 193-197, 1993.
28. Schwartz, J.P., N. Nishiyama, D. Wilson and T. Taniwaki. Receptor-mediated regulation of neuropeptide gene expression in astrocytes. Glia 11: 185-190, 1994.
29. Seko, Y., N. Takahashi, K. Tobe, T. Kadowaki and Y. Yazaki. Hypoxia and hypoxia/reoxygenation activate p65PAK, p38 MAPK, and SAPK in cultured rat cardiac myocytes. Biochem. Biophys. Res. Commun. 239: 840-844, 1997.
30. Tsacopoulos, M. and P.J. Magistretti. Metabolic coupling between glia and neurons. J. Neurosci. 16: 877-885, 1996.
31. Varga, E., A. Bodi, P. Ferdinandy, M.T. Droy-Lefaix, I.E. Blasig and A. Tosaki, The protective effect of EGb 761 in isolated ischemic/reperfused rat hearts: A link between cardiac function and nitric oxide production. J. Cardiovasc. Pharmacol. 34: 711-717, 1999.
32. Zhu, D., R. Li, G. Liu and W. Hua. Nimodipine inhibits calcium-independent nitric oxide synthase activity in transient focal cerebral ischemia rats and cultured mouse astroglial cells. Life Sci. 65: 221-231, 1999.