Enhancement of a pentacyclic tyrosine kinase inhibitor production in Cladosporium cf. cladosporioides by Cladosporol

Applied Microbiology and Biotechnology

Volumn 69, Issue 6, 2006, Pages 718-721

  Assante, Gemma ^a   Bava, Adriana ^b   Nasini, Gianluca ^b  

^a Facolta di Farmacia   (Italy)

^b POLITECNICO DI MILANO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCONVERSION; CELL CULTURE; DERIVATIVES; DNA; ENZYMES; METABOLITES;

CLADOSPOROL; FUNGAL BIOMASS; TOPOISOMERASE;

ENZYME INHIBITION;

CLADOSPOROL; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ENZYME;

ARTICLE; BIOTRANSFORMATION; CLADOSPORIUM; COMPARATIVE STUDY; CYTOKINE PRODUCTION; ENZYMATIC DEGRADATION; ENZYME KINETICS; FUNGAL BIOMASS; FUNGAL CELL CULTURE; FUNGUS GROWTH; NONHUMAN;

BIOTRANSFORMATION; CHROMONES; CLADOSPORIUM; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; FLUORENES; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; MOLECULAR STRUCTURE; PROTEIN-TYROSINE KINASES;

CLADOSPORIUM; CLADOSPORIUM CLADOSPORIOIDES; FUNGI;

EID: 31144433794     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-005-0054-2     Document Type: Article

References (14)

1. Arnone A, Assante G, Merlini L, Nasini G (1989) Structure and stereochemistry of Cladochrome D and E, novel perylenequinone pigments from C. cladosporioides. Gazz Chim Ital 119: 557-559
2. Assante G, Maffi D, Saracchi M, Farina G, Moricca S, Ragazzi A (2004) Hystological studies on the mycoparasitism of Cladosporium tenuissimum and urediniospores of Uromyces appendiculatus. Mycol Res 108:170-182
3. Brauers G, Ebel R, Edrada R, Wray V, Berg A, Gräfe U, Proksch P (2001) Hortein, a new natural product from the fungus Hortaea werneckii associated with the sponge Aplysina aerophoba. J Nat Prod 64:651-652
4. Edwards RL, Lockert HJ (1976) Constituents of higher fungi. Part XVI. Bulgarhodin and bulgarein, novel benzofluoranthenequinones from the fungus Bulgaria inquinans. J Chem Soc, Perkin Trans I 2149-2155
5. Fujii N, Yamashita Y, Saitoh Y, Nakano H (1993) Induction of mammalian DNA topoisomerase I-mediated DNA cleavage and DNA winding by bulgarein. J Biol Chem 268:13160-13165
6. Koyama K, Kuramochi D, Kinoshita K, Takahashi K (2002) Hypoxylonols A and B, novel reduced benzo[j]fluoranthene derivatives from the mushroom Hypoxylon truncatum. J Nat Prod 65:1489-1490
7. Liu LF (1994) DNA topoisomerases: biochemistry and molecular biology. Advances in Pharmacology, vol 29A, Academic Press, New York, USA, p 320
8. Moricca S, Ragazzi A, Mitchelson KR, Assante G (2001) Antagonism of the two-needle pine stem rust fungi Cronartium flaccidum and Peridermium pini by Cladosporium tenuissimum in vitro and in planta. Phytopathology 91:457-468
9. Nasini G, Arnone A, Assante G, Bava A, Moricca S, Ragazzi A (2004) Secondary mould metabolites of Cladosporium tenuissimum, a hyperparasite rust fungi. Phytochemistry 65:2107-2111
10. Quang DN, Hashimoto T, Tanaka M, Baumgartner M, Stadler M, Asakawa Y (2002) Chemical constituents of the Ascomycete Daldinia concentrica. J Nat Prod 65:1869-1874
11. Sakagami Y, Sano A, Hara O, Mikawa T, Marumo S (1995) Cladosporol, β-1,3-glucan biosynthesis inhibitor, isolated by the fungus Cladosporium cladosporioides. Tetrahedron Lett 36: 1469-1472
12. Tamaoki T, Nakano H (1990) Potent and specific inhibitors of protein kinase C of microbial origin. Bio/Technology 8:732-735
13. Weiss U, Merlini L, Nasini G (1987) Naturally occurring perylenequinones. Progress in the chemistry of organic natural products, vol 57, Springer, Wien, pp 1-71
14. Wrigley SK, Ainsworth AM, Kau DA, Martin SM, Bahl S, Tang JS, Hardick DJ, Rawlins P, Sadheghi R, Moore M (2001) Novel reduced benzo[j]fluoranthen-3-ones from Cladosporium cf. cladosporioides with cytokine production and tyrosine kinase inhibitory properties. J Antibiot 54:479-488