Studies of interaction of trichloro{η2-cis-N,N-dimethyl-1- [6-(N′,N′-dimethyl-ammoniummethyl)-cyclohex-3-ene-1-yl] -methylammonium}platinum(II) chloride with DNA: Effects on secondary and tertiary structures of DNA. Cytotoxic assays on human ovarian cancer cell lines, resistant and non-resistant to cisplatin

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 5, 2006, Pages 1565-1572

  Gay, Marina ^a   Montaña, Ángel M ^a   Moreno, Virtudes ^a   Prieto, María José ^a   Pérez, José Manuel ^b   Alonso, Carlos ^b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Complex; Atomic force microscopy; Cancer cell lines resistant and non resistant to cisplatin; Circular dichroism; Cytotoxicity; Electrophoresis; Platinum(II)

Indexed keywords

[ETA 2 N,N DIMETHYL 1 [6 (N',N' DIMETHYL AMMONIUMMETHYL) CYCLOHEX 3 ENE 1 YL] METHYL AMMONIUM] PLATINUM CHLORIDE; ANTINEOPLASTIC AGENT; CISPLATIN; PLASMID DNA; UNCLASSIFIED DRUG;

ARTICLE; ATOMIC FORCE MICROSCOPY; CANCER CELL CULTURE; CELL COUNT; CELL VIABILITY; CHEMICAL BOND; CIRCULAR DICHROISM; COLORIMETRY; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA BINDING; DNA STRUCTURE; DRUG DNA INTERACTION; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG SYNTHESIS; ELECTROPHORETIC MOBILITY; HUMAN; HUMAN CELL; OVARY CANCER; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CISPLATIN; COLORIMETRY; DNA; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORESIS, AGAR GEL; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MICROSCOPY, ATOMIC FORCE; NUCLEIC ACID CONFORMATION; ORGANOPLATINUM COMPOUNDS; OVARIAN NEOPLASMS;

EID: 31044446503     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.016     Document Type: Article

References (33)

1. B. Rosenberg, L. Van Camp, and T. Krigas Nature 205 1965 698 699
2. B. Rosenberg, L. Van Camp, J.E. Trosko, and V.H. Mansour Nature 222 1969 385 386
3. R.B. Weiss, and M.C. Chistian Drugs 46 3 1993 360 377
4. M.A. Fuertes, C. Alonso, and J.M. Pérez Chem. Rev. 103 2003 645 662
5. E. Wong, and C.M. Giandomenico Chem. Rev. 99 1999 2451 2466
6. Z. Guo, and P.J. Sadler Angew. Chem. Int. Ed. 38 1999 1512 1531
7. E.R. Jamieson, and S.J. Lippard Chem. Rev. 99 1999 2467 2498
8. J. Reedijk, A.M.J. Fichtinger-Shepman, A.T. van Oosterom, and P. van de Putte Structure and Bonding 67 1987 53 89
9. P.M. Takahara, C.A. Frederick, and S.J. Lippard Nature 377 1995 649 652
10. A. Gelasco, and J.S. Lippard Biochemistry 37 1998 9230 9239
11. D. Yang, S.S.G.E. van Boom, J. Redjick, J.H. van Boom, and A.H.J. Wang Biochemistry 34 1995 12912 12920
12. D.B. Brown, D.B. Khokhar, A.R. Hacker, and M.P.J.J. McCormack Inorg. Chim. Acta 67 1982 45 52
13. M. Gay, A.M. Montaña, V. Moreno, M. Font-Bardia, and X. Solans J Organomet Chem 690 2005 4856 4866
14. E.D. Middlemas, and L.D. Quin J. Org. Chem. 44 1979 2587 2589
15. M. Gay, A.M. Montaña, V. Moreno, M. Font-Bardia, and X. Solans Chem. Eur. J. 11 2005 2130 2134
16. V.I. Ivanov, L.E. Minchenkova, A.K. Schvolkina, and A.I. Poletavev Biopolymers 12 1973 89 95
17. J.P. Maquet, and J.B. Butour Biochemie 60 1978 901 905
18. Feilfeder D. Técnicas de Bioquímica y Biologia Molecular. Serie de Biologia Molecular, Editorial Reverté S.A., Barcelona, 1991.
19. Adams, R. L. P.; Knowler, J. T.; Leadre, D. P. In The Biochemistry of the Nucleic Acids, 11th ed.; Chapman & Hall: London, UK, 1992.
20. P. Nielsen, W. Zhen, U. Henriksen, and O. Buchardt Biochemistry 27 1988 67
21. M.V. Keck, and S.J. Lippard J. Am. Chem. Soc. 114 1992 3386
22. C. Bustamante, and R. Garcia Investigación y Ciencia 1997 246
23. B.E. Bowler, L.S. Holis, and S.J. Lippard J. Am. Chem. Soc. 106 1984 6102
24. R.T. Espezo, and J. Lebowitz Anal. Biochem. 72 1976 95
25. G.L. Cohen, W.R. Bauer, J.K. Barton, and S.J. Lippard Science 203 1979 1014
26. W. Fritzche, A. Schaper, and T.M. Jovin Eur. Microsc. Anal. 1996 5 7
27. C. Bustamante, J. Vesenka, C.L. Tang, W. Rees, M. Guthod, and R. Keller Biochemistry 31 1992 22 26
28. Z. Shao, J. Mou, D.M. Czajkowsky, J. Yang, and J.Y. Yuan Adv. Phys. 46 1996 1 86
29. Saenger, W. In Principles of Nucleic Acid Structure, Springer: New York, 1984.
30. G.L. Cohen, W.R. Bauer, J.K. Barton, and S.J. Lippard Science 203 1979 1014 1016
31. B. Onoa, G. Cervantes, V. Moreno, and M.J. Prieto Nucleic Acids Res. 26 6 1998 1473 1480
32. L.R. Kelland, and C.D.J. Barnard Drugs Future 23 1999 1062 1065
33. P. Skehan, R. Storeng, D. Sandiero, A. Monks, J. McMahon, D. Vistica, J.T. Warren, H. Bokesh, S. Kenney, and M.R. Boyd J. Natl. Cancer Inst. 82 1990 1107 1112