Circadian variations in the pharmacokinetics, tissue distribution and urinary excretion of nifedipine after a single oral administration to rats

Biopharmaceutics and Drug Disposition

Volumn 26, Issue 9, 2005, Pages 427-437

  Cao, Qing Ri ^a   Kim, Tae Wan ^a   Choi, Jun Shik ^b   Lee, Beom Jin ^a  

^a Kangwon National University   (South Korea)

^b Chosun University   (South Korea)

Author keywords

Circadian variations; Dosing time; Nifedipine; Pharmacokinetics; Rest activity cycle; Tissue distribution; Urinary excretion

Indexed keywords

NIFEDIPINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BIOLOGICAL RHYTHM; CIRCADIAN RHYTHM; CLINICAL OBSERVATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; DRUG URINE LEVEL; HUMAN; NONHUMAN; RAT; REST; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; TIME; URINARY EXCRETION;

ADMINISTRATION, ORAL; ANIMALS; CALCIUM CHANNEL BLOCKERS; CIRCADIAN RHYTHM; MALE; METABOLIC CLEARANCE RATE; NIFEDIPINE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 30944465481     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.474     Document Type: Article

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