Sirolimus for rescue of recurrent acute rejection and diabetes mellitus after liver transplantation. Report of one case;Rescate con Sirolimus por rechazo agudo recurrente y diabetes mellitus en trasplante hepático. Caso clínico pediátrico

Revista Medica de Chile

Volumn 133, Issue 10, 2005, Pages 1221-1224

  Roque E, Jorge ^a,c   Ríos M, Gloria ^a   Hepp K, Juan ^a   Humeres A, Roberto ^a   Ríos R, Horacio ^a   M Herrera, José ^a   Rius A, Montserrat ^b  

^a UNIVERSIDAD DEL DESARROLLO   (Chile)

^b Enfermera Universitaria

^c NONE   (Chile)

Author keywords

Liver transplantation; Sirolimus; Tacrolimus

Indexed keywords

EID: 30944447646     PISSN: 00349887     EISSN: 07176163     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. JAIN A, REYES J, KASHYAP R, ROHAL S, ABU-ELMAGD K, STARZL T ET AL. What have we learned about primary liver transplantation under tacrolimus immunosuppression? Long Term follow-up of the first 1000 patients. Ann Surg 1999; 230: 441-8.
2. SINDHI R. Sirolimus in pediatric transplant recipients. Transplant Proc 2003; 35 (3 Suppl): 113S-114S.
3. SINDHI R, GANJOO J, MCGHEE W, MAZARIEGOS G, REYES J. Preliminary immunosuppression withdrawal strategies with sirolimus in children with liver transplant. Transplant Proc 2002; 34: 1972-3.
4. TROTTER JF. Sirolimus in liver transplantation. Transplant Proc 2003; 35 (Suppl 3A): 193S-200S.
5. NEFF GW, MONTALBANO M, TZAKIS AG. Ten years of sirolimus therapy in orthotopic liver transplant recipients. Transplant Proc 2003; 35 (3 Suppl): 209S-216S.
6. KAHAN BD. The potential role of rapimycin in pediatric transplantion as observed from adult studies. Pediatr Transplant 1999; 3: 175-80.
7. SCHUBERT M, VENKATARAMANAN R, HOLT DW, SHAW LM, MCGHEE W, REYES J ET AL. Pharmacokinetics of sirolimus and tacrolimus in pediatric transplant patients. Am J Transplant 2004; 4: 767-73.
8. NEFF GW, MONTALBANO M, SLAPAK-GREEN G, BERNEY T, BEJARANO P, JOSHI A ET AL. A retrospective review of sirolimus (Rapamune) therapy in orthotopic liver transplant recipients diagnostised with chronic rejection. Liver Transplantation 2003; 9: 477-83.
9. KELLY PA, GRUBER SA, BEHBOD F, KAHAN BD. Sirolimus, a new, potent immunossuppressive agent. Pharmacotherapy 1997; 17: 1148-56.
10. CHANG GJ, MAHANTY HD, QUAN D, FREISE CE, ASCHER NL, ROBERTS JP ET AL. Experience with the use of sirolimus in liver transplantation-use in patients for whom calcineurin inhibitors are contraindicated. Liver Transpl 2000; 6: 734-40.
11. JIMÉNEZ-RIVERA C, AVITZUR Y, FECTEAU AH, JONES N, GRANT D, NG VL. Sirolimus for pediatric liver transplant recipients with post-transplant lymphoproliferative disease and hepatoblastoma. Pediatr Transplant 2004; 8: 243-8.
12. SINDHI R, WEBBER S, VENKATARAMANAN R, MCGHEE W, PHILLIPS S, SMITH A ET AL. Sirolimus for rescue and primary immunosuppression in transplanted children receiving tacrolimus. Transplantation 2001; 72: 851-4.
13. PARROT NR. Immunosuppression: «What's new?». En Transplantation Surgery: Current Dilemmas. Edited by John L R Forsythe. W.B. Saunders Company Limited. Second edition 2001; 101131.
14. DUNKELBERG JC, TROTER JF, WACHS M, KUGELMAS M, STREINBERG T, EVERSON GT ET AL. Sirolimus as primary immunosuppression in liver transplantation is not associated with hepatic artery or wound complications. Liver Transpl 2003; 9: 463-8.
15. FAIRBANKS KD, EUSTACE JA, FINE D, THULUVATH PJ. Renal function improves in liver transplant recipients when switched from a calcineurin inhibitor to sirolimus. Liver Transpl 2003; 9: 1079-85.
16. NEFF GW, MONTALBANO M, SLAPK-GREEN G, MEYER D, BERNEY T, SAFDAR K ET AL. Sirolimus therapy in orthotopic liver transplant recipients with calcineurin inhibitor related chronic renal insufficiency. Transpl Prc 2003; 35: 3029-31.
17. MARAMATTOM BV, EELCO FMW. Sirolimus may not cause neurotoxicity in kidney and liver transplant recipients. Neurology 2004; 63: 1958-9.
18. MARKELL M. New-onset diabetes mellitus in transplant patients: pathogenesis, complications, and management. Am J Kidney Dis 2004; 43: 953-65.
19. NEFF GW, RUIZ P, MADARIAGA JR, NISHIDA S, MONTALBANO M, MEYER D ET AL. Sirolimus associated hepatotoxicity in liver transplantation. Ann Pharmacother 2004; 38: 1593-6.
20. FLECHNER SM, ZHOU L, DERWEESH I, MASTROIANNI B, SAVAS K, GOLDFARB D ET AL. The impact of sirolimus, mycophenolate mofetil, cyclosporine, azathioprne, and steroids on wound healing in 513 kidney-transplant recipients. Transplantation 2003; 76: 1729-34.
21. WATSON CJ, FRIEND PJ, JAMIESON NV, FRICK TW, ALEXANDER G, GIMSON AE ET AL. Sirolimus: a potent new immunosuppressant for liver transplantation. Transplantation 1999; 67: 505-9.