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Careful addition of lithiated dimethyl methylphosphonate solution at -78°C to the methyl ester of acid 15 allowed for selective addition into the methyl ester over the pivaloyl ester.
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Conditions: PPTS, benzene, 40°C, aspirator vacuum. See Supporting Information for more detail. See: Allwein, S. P.; Cox, J. M.; Howard, B. E.; Johnson, H. W. B.; Rainier, J. D. Tetrahedron 2002, 58, 1997.
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30944455514
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See Supporting Information
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See Supporting Information.
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