Role of anti-TGF-β antibodies in the treatment of renal injury

Cytokine and Growth Factor Reviews

Volumn 17, Issue 1-2, 2006, Pages 89-96

  Gagliardini, Elena ^a   Benigni, Ariela ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Angiotensin II blockers; Progressive nephropathies; Proteinuria; Renal fibrosis; Transforming growth factor

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ANGIOTENSIN II; ANTISENSE OLIGODEOXYNUCLEOTIDE; CHIMERIC PROTEIN; COLLAGEN TYPE 4; DECORIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN 1; LAMININ; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; PLASMINOGEN ACTIVATOR INHIBITOR; RANTES; SCLEROPROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA ANTIBODY;

CANCER EPIDEMIOLOGY; CYTOKINE PRODUCTION; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG INHIBITION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLOMERULONEPHRITIS; GLOMERULOSCLEROSIS; GLOMERULUS; HYPERGLYCEMIA; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOPATHOLOGY; IMMUNOREGULATION; KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY INJURY; LUPUS ERYTHEMATOSUS NEPHRITIS; NEPHROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RECEPTOR BINDING; RENAL PROTECTION; REVIEW; SIGNAL TRANSDUCTION; URETER OBSTRUCTION; WOUND HEALING;

ANIMALIA;

EID: 30944442610     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2005.09.005     Document Type: Article

References (85)

1. J.L. Xue, J.Z. Ma, T.A. Louis, and A.J. Collins Forecast of the number of patients with end-stage renal disease in the United States to the year J Am Soc Nephrol 12 2001 2753 2758
2. M.J. Lysaght Maintenance dialysis population dynamics: current trends and long-term implications J Am Soc Nephrol 13 Suppl 1 2002 S37 S40
3. B. Gridelli, and G. Remuzzi Strategies for making more organs available for transplantation N Engl J Med 343 2000 404 410
4. J. Massague The transforming growth factor-beta family Annu Rev Cell Biol 6 1990 597 641
5. T. Ando, S. Okuda, K. Tamaki, K. Yoshitomi, and M. Fujishima Localization of transforming growth factor-beta and latent transforming growth factor-beta binding protein in rat kidney Kidney Int 47 1995 733 739
6. T. Yanagida, S. Okuda, K. Tamaki, T. Ando, Y. Yonemitsu, and K. Sueishi Determination of the renal cells expressing TGF-beta-1 mRNA and LTBP mRNA in adriamycin (ADR)-nephropathy in rats by non RI in situ hybridisation J Am Soc Nephrol 5 1994
7. K. MacKay, P. Kondaiah, D. Danielpour, H.A. Austin III, and P.D. Brown Expression of transforming growth factor-beta 1 and beta 2 in rat glomeruli Kidney Int 38 1990 1095 1100
8. H.M. Wilson, A.W. Minto, P.A. Brown, L.P. Erwig, and A.J. Rees Transforming growth factor-beta isoforms and glomerular injury in nephrotoxic nephritis Kidney Int 57 2000 2434 2444
9. K. MacKay, L.J. Striker, J.W. Stauffer, T. Doi, L.Y. Agodoa, and G.E. Striker Transforming growth factor-beta. Murine glomerular receptors and responses of isolated glomerular cells J Clin Invest 83 1989 1160 1167
10. S.J. Shankland, J. Pippin, R.H. Pichler, K.L. Gordon, S. Friedman, and L.I. Gold Differential expression of transforming growth factor-beta isoforms and receptors in experimental membranous nephropathy Kidney Int 50 1996 116 124
11. G.C. Blobe, W.P. Schiemann, and H.F. Lodish Role of transforming growth factor beta in human disease N Engl J Med 342 2000 1350 1358
12. W. Wang, X.R. Huang, A.G. Li, F. Liu, J.H. Li, and L.D. Truong Signaling mechanism of TGF-{beta}1 in prevention of renal inflammation: role of Smad7 J Am Soc Nephrol 16 2005 1371 1383
13. G. Remuzzi, and T. Bertani Pathophysiology of progressive nephropathies N Engl J Med 339 1998 1448 1456
14. G. Remuzzi Nephropathic nature of proteinuria Curr Opin Nephrol Hypertens 8 1999 655 663
15. C. Zoja, M. Morigi, M. Figliuzzi, I. Bruzzi, S. Oldroyd, and A. Benigni Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins Am J Kidney Dis 26 1995 934 941
16. Y. Wang, J. Chen, L. Chen, Y.C. Tay, G.K. Rangan, and D.C. Harris Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein J Am Soc Nephrol 8 1997 1537 1545
17. C. Zoja, R. Donadelli, S. Colleoni, M. Figliuzzi, S. Bonazzola, and M. Morigi Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kB activation Kidney Int 53 1998 1608 1615
18. B.A. Yard, E. Chorianopoulos, D. Herr, and F.J. van der Woude Regulation of endothelin-1 and transforming growth factor-beta1 production in cultured proximal tubular cells by albumin and heparan sulphate glycosaminoglycans Nephrol Dial Transplant 16 2001 1769 1775
19. G. Wolf, R. Schroeder, F.N. Ziyadeh, and R.A. Stahl Albumin up-regulates the type II transforming growth factor-beta receptor in cultured proximal tubular cells Kidney Int 66 2004 1849 1858
20. M. Abbate, C. Zoja, M. Morigi, D. Rottoli, S. Angioletti, and S. Tomasoni Transforming growth factor-β1 is up-regulated by podocytes in response to excess intraglomerular passage of proteins Am Pathol 161 2002 2179 2193
21. L.A. Stephenson, L.B. Haney, I.M. Hussaini, L.R. Karns, and W.F. Glass II Regulation of smooth muscle alpha-actin expression and hypertrophy in cultured mesangial cells Kidney Int 54 1998 1175 1187
22. Y. Isaka, Y. Fujiwara, N. Ueda, Y. Kaneda, T. Kamada, and E. Imai Glomerulosclerosis induced by in vivo transfection of transforming growth factor-β or platelet-derived growth factor gene into the rat kidney J Clin Invest 92 1993 2597 2601
23. A.B. Roberts, and M.B. Sporn The transforming growth factor-beta s M.B. Sporn Peptide Growth Factors and Their Receptors vol. 1 1990 Springer Berlin 419 472
24. J.A. Bruijn, A. Roos, B. De Geus, and E. De Heer Transforming growth factor-beta and the glomerular extracellular matrix in renal pathology J Lab Clin Med 123 1994 34 47
25. S. Tomooka, W.A. Border, B.C. Marshall, and N.A. Noble Glomerular matrix accumulation is linked to inhibition of the plasmin protease system Kidney Int 42 1992 1462 1469
26. S. Kagami, W.A. Border, E. Ruoslahti, and N.A. Noble Coordinated expression of beta 1 integrins and transforming growth factor-beta-induced matrix proteins in glomerulonephritis Lab Invest 69 1993 68 76
27. W.A. Border, and N.A. Noble Transforming growth factor β in tissue fibrosis N Engl J Med 331 1994 1286 1292
28. M. Bitzer, R.B. Sterzel, and E.P. Bottinger Transforming growth factor-beta in renal disease Kidney Blood Press Res 21 1998 1 12
29. A. Miyajima, J. Chen, C. Lawrence, S. Ledbetter, R.A. Soslow, and J. Stern Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction Kidney Int 58 2000 2301 2313
30. L.J. Ma, S. Nakamura, J.S. Whitsitt, C. Marcantoni, J.M. Davidson, and A.B. Fogo Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1 Kidney Int 58 2000 2425 2436
31. C.L. Jones, S. Buch, M. Post, L. McCulloch, E. Liu, and A.A. Eddy Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats Am J Pathol 141 1992 1381 1396
32. T. Nakamura, I. Ebihara, M. Fukui, S. Osada, I. Nagaoka, and S. Horikoshi Messenger RNA expression for growth factors in glomeruli from focal glomerular sclerosis Clin Immunol Immunopathol 66 1993 33 42
33. L.J. Ma, S. Jha, H. Ling, A. Pozzi, S. Ledbetter, and A.B. Fogo Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats Kidney Int 65 2004 106 115
34. M. Abbate, C. Zoja, D. Rottoli, D. Corna, S. Tomasoni, and G. Remuzzi Proximal tubular cells promote fibrogenesis by TGF-β1-mediated induction of peritubular myofibroblasts Kidney Int 61 2002 2066 2077
35. A. Desmoulière, A. Geinoz, F. Gabbiani, and G. Gabbiani Transforming growth factor-beta1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts J Cell Biol 122 1993 103 111
36. H. Okada, T.M. Danoff, R. Kalluri, and E.G. Neilson Early role of Fsp1 in epithelial-mesenchymal transformation Am J Physiol 273 1997 F563 F574
37. C. Zoja, D. Corna, I. Bruzzi, C. Foglieni, T. Bertani, and G. Remuzzi Passive Heymann nephritis: evidence that angiotensin-converting enzyme inhibition reduces proteinuria and retards renal structural injury Exp Nephrol 4 1996 213 221
38. C. Zoja, D. Corna, D. Camozzi, D. Cattaneo, D. Rottoli, and C. Batani How to fully protect the kidney in a severe model of progressive nephropathy: a multidrug approach J Am Soc Nephrol 13 2002 2898 2908
39. J.S. Bollineni, and A.S. Reddi Transforming growth factor-beta 1 enhances glomerular collagen synthesis in diabetic rats Diabetes 42 1993 1673 1677
40. A. Erman, S. Veksler, U. Gafter, G. Boner, C. Wittenberg, and D.J. van Dijk Renin-angiotensin system blockade prevents the increase in plasma transforming growth factor beta 1, and reduces proteinuria and kidney hypertrophy in the streptozotocin-diabetic rat J Renin Angiotensin Aldosterone Syst 5 2004 146 151
41. R.E. Gilbert, A. Cox, L.L. Wu, T.J. Allen, U.L. Hulthen, and G. Jerums Expression of transforming growth factor-β1 and type IV collagen in the renal tubulointerstitium in experimental diabetes Diabetes 47 1998 414 422
42. A. Benigni, C. Zoja, D. Corna, C. Zatelli, S. Conti, and M. Campana Add-on anti-TGF-β antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat J Am Soc Nephrol 14 2003 1816 1824
43. S.J. Shankland, J.W. Scholey, H. Ly, and K. Thai Expression of transforming growth factor-beta 1 during diabetic renal hypertrophy Kidney Int 46 1994 430 442
44. C. Hill, A. Logan, C. Smith, H. Gronbaek, and A. Flyvbjerg Angiotensin converting enzyme inhibitor suppresses glomerular transforming growth factor beta receptor expression in experimental diabetes in rats Diabetologia 44 2001 495 500
45. B.L. Riser, M. Denichilo, P. Cortes, C. Baker, J.M. Grondin, and J. Yee Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis J Am Soc Nephrol 11 2000 25 38
46. O. Gonzalez-Albarran, O. Gomez, E. Ruiz, P. Vieitez, and R. Garcia-Robles Role of systolic blood pressure on the progression of kidney damage in an experimental model of type 2 diabetes mellitus, obesity, and hypertension (Zucker rats) Am J Hypertens 16 2003 979 985
47. K. Shinomiya, M. Fukunaga, H. Kiyomoto, K. Mizushige, T. Tsuji, and T. Noma A role of oxidative stress-generated eicosanoid in the progression of arteriosclerosis in type 2 diabetes mellitus model rats Hypertens Res 25 2002 91 98
48. S. Kagami, W.A. Border, D.E. Miller, and N.A. Noble Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-β expression in rat glomerular mesangial cells J Clin Invest 93 1994 2431 2437
49. B.L. Riser, S. Ladson-Wofford, A. Sharba, P. Cortes, K. Drake, and C.J. Guerin TGF-beta receptor expression and binding in rat mesangial cells: modulation by glucose and cyclic mechanical strain Kidney Int 56 1999 428 439
50. F.N. Ziyadeh, K. Sharma, M. Ericksen, and G. Wolf Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-β J Clin Invest 93 1994 536 542
51. M.V. Rocco, Y. Chen, S. Goldfarb, and F.N. Ziyadeh Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule Kidney Int 41 1992 107 114
52. F.N. Ziyadeh, D.C. Han, J.A. Cohen, J. Guo, and M.P. Cohen Glycated albumin stimulates fibronectin gene expression in glomerular mesangial cells: involvement of the transforming growth factor-beta system Kidney Int 53 1998 631 638
53. C.W. Yang, H. Vlassara, E.P. Peten, C.J. He, G.E. Striker, and L.J. Striker Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease Proc Natl Acad Sci USA 91 1994 9436 9440
54. G. Zhou, C. Li, and L. Cai Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway Am J Pathol 165 2004 2033 2043
55. T. Yamamoto, T. Nakamura, N.A. Noble, E. Ruoslahti, and W.A. Border Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy Proc Natl Acad Sci USA 90 1993 1814 1818
56. M. Kitamura, and T.S. Suto TGF-beta and glomerulonephritis: anti-inflammatory versus prosclerotic actions Nephrol Dial Transplant 12 1997 669 679
57. W.A. Border, N.A. Noble, T. Jamamoto, J.R. Harper, Y. Yamaguchi, and M.D. Pierschbacher Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease Nature 360 1992 361 364
58. S. Komesli, D. Vivien, and P. Dutartre Chimeric extracellular domain type II transforming growth factor (TGF)-beta receptor fused to the Fc region of human immunoglobulin as a TGF-beta antagonist Eur J Biochem 254 1998 505 513
59. Y. Isaka, Y. Akagi, Y. Ando, M. Tsujie, T. Sudo, and N. Ohno Gene therapy by transforming growth factor-β receptor-IgG-Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis Kidney Int 55 1999 465 475
60. Y. Akagi, Y. Isaka, M. Arai, T. Kaneko, M. Takenaka, and T. Moriyama Inhibition of TGF-beta 1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis Kidney Int 50 1996 148 155
61. H.Y. Lan, W. Mu, N. Tomita, X.R. Huang, J.H. Li, and H.J. Zhu Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound- microbubble system in rat UUO model J Am Soc Nephrol 14 2003 1535 1548
62. C.C. Hou, W. Wang, X.R. Huang, P. Fu, T.H. Chen, and D. Sheikh-Hamad Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney Am J Pathol 166 2005 761 771
63. M. Sato, Y. Muragaki, S. Saika, A.B. Roberts, and A. Ooshima Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction J Clin Invest 112 2003 1486 1494
64. H. Fukasawa, T. Yamamoto, H. Suzuki, A. Togawa, N. Ohashi, and Y. Fujigaki Treatment with anti-TGF-beta antibody ameliorates chronic progressive nephritis by inhibiting Smad/TGF-beta signaling Kidney Int 65 2004 63 74
65. M. Islam, J.F. Burke Jr., T.A. McGowan, Y. Zhu, S.R. Dunn, and P. McCue Effect of anti-transforming growth factor-beta antibodies in cyclosporine-induced renal dysfunction Kidney Int 59 2001 498 506
66. H. Ling, X. Li, S. Jha, W. Wang, L. Karetskaya, and B. Pratt Therapeutic role of TGF-beta-neutralizing antibody in mouse cyclosporin A nephropathy: morphologic improvement associated with functional preservation J Am Soc Nephrol 14 2003 377 388
67. K. Sharma, Y. Jin, J. Guo, and F.N. Ziyadeh Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice Diabetes 45 1996 522 530
68. F.N. Ziyadeh, B.B. Hoffman, D. Cheol Han, M.C. Iglesias-de la cruz, S. Won Hong, and M. Isono Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice PNAS 97 2000 8015 8020
69. S. Chen, M.C. Iglesias-de la Cruz, B. Jim, S.W. Hong, M. Isono, and F.N. Ziyadeh Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice Biochem Biophys Res Commun 300 2003 16 22
70. A.J. Dahly, K.M. Hoagland, A.K. Flasch, S. Jha, S.R. Ledbetter, and R.J. Roman Antihypertensive effects of chronic anti-TGF-β antibody therapy in Dahl S rats Am J Physiolol 283 2002 R757 R767
71. F.J. Kelly, S. Anderson, M.M. Thompson, T.T. Oyama, T.M. Kennefick, and C.L. Corless Acute and chronic renal effects of recombinant human TGF-beta2 in the rat J Am Soc Nephrol 10 1999 1264 1273
72. R. Sharma, A. Khanna, M. Sharma, and V.J. Savin Transforming growth factor-beta1 increases albumin permeability of isolated rat glomeruli via hydroxyl radicals Kidney Int 58 2000 131 136
73. T. Yamamoto, N.A. Noble, A.H. Cohen, C.C. Nast, A. Hishida, and L.I. Gold Expression of transforming growth factor-beta isoforms in human glomerular diseases Kidney Int 49 1996 461 469
74. K. Yoshioka, T. Takemura, K. Murakami, M. Okada, S. Hino, and H. Miyamoto Transforming growth factor-beta protein and mRNA in glomeruli in normal and diseased human kidneys Lab Invest 68 1993 154 163
75. J.H. Kim, B.K. Kim, K.C. Moon, H.K. Hong, and H.S. Lee Activation of the TGF-beta/Smad signaling pathway in focal segmental glomerulosclerosis Kidney Int 64 2003 1715 1721
76. P. De Muro, R. Faedda, P. Fresu, A. Masala, A. Cigni, and G. Concas Urinary transforming growth factor-beta 1 in various types of nephropathy Pharmacol Res 49 2004 293 298
77. R.W. Chan, F.M. Lai, E.K. Li, L.S. Tam, T.Y. Wong, and C.Y. Szeto Expression of chemokine and fibrosing factor messenger RNA in the urinary sediment of patients with lupus nephritis Arthritis Rheum 50 2004 2882 2890
78. A. Pfeiffer, K. Middelberg-Bisping, C. Drewes, and H. Schatz Elevated plasma levels of transforming growth factor-beta 1 in NIDDM Diabet Care 19 1996 1113 1117
79. H. Sato, M. Iwano, Y. Akai, H. Kurioka, A. Kubo, and T. Yamaguchi Increased excretion of urinary transforming growth factor beta 1 in patients with diabetic nephropathy Am J Nephrol 18 1998 490 494
80. J.A. Fagerudd, P.H. Groop, E. Honkanen, A.M. Teppo, and C. Gronhagen-Riska Urinary excretion of TGF-beta 1. PDGF-BB and fibronectin in insulin-dependent diabetes mellitus patients Kidney Int Suppl 63 1997 S195 S197
81. D.R. Cha, I.S. Kim, Y.S. Kang, S.Y. Han, K.H. Han, and C. Shin Urinary concentration of transforming growth factor-beta-inducible gene-h3(beta ig-h3) in patients with Type 2 diabetes mellitus Diabet Med 22 2005 14 20
82. P. Ruggenenti, A. Fassi, A.P. Ilieva, S. Bruno, I.P. Iliev, and V. Brusegan Preventing microalbuminuria in type 2 diabetes N Engl J Med 351 2004 1941 1951
83. B.M. Brenner, M.E. Cooper, D. Zeeuw Dd, J.P. Grunfeld, W.F. Keane, and K. Kurokawa The losartan renal protection study - rationale, study design and baseline characteristics of RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) J Renin Angiotensin Aldosterone Syst 1 2000 328 335
84. M. Praga, C.F. Andrade, J. Luno, M. Arias, R. Poveda, and J. Mora Antiproteinuric efficacy of losartan in comparison with amlodipine in non-diabetic proteinuric renal diseases: a double-blind, randomized clinical trial Nephrol Dial Transplant 18 2003 1806 1813
85. J.H. Song, S.W. Lee, J.H. Suh, E.S. Kim, S.B. Hong, and K.A. Kim The effects of dual blockade of the renin-angiotensin system on urinary protein and transforming growth factor-beta excretion in 2 groups of patients with IgA and diabetic nephropathy Clin Nephrol 60 2003 318 326