Synthesis of some new N-substituted pyrroles, pyrrolo[1,2-a]quinazoline, and diaza-as-indacene derivatives

Synthetic Communications

Volumn 36, Issue 1, 2006, Pages 83-89

  Abdelrazek, Fathy M ^a   Metwally, Nadia H ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

2 phenyl 1,1,3 tricyano 3 bromopropene; Aromatic amines; Diaza as indacenes; Pyrroles; Pyrrolo 1,2 a quinazolines

Indexed keywords

4 IMINO 2,7 DIPHENYL 4,5 DIHYDRO 1 OXA 5,8A DIAZA[AS]INDACENE 6,8 DICARBONITRILE; 4 IMINO 3,7 DIPHENYL 4,5 DIHYDRO 1 THIA 5,8A DIAZA[AS]INDACENE 6,8 DICARBONITRILE; 4 OXO 2,7 DIPHENYL 4,5 DIHYDRO 1 OXA 5,8A DIAZA[AS]INDACENE 6,8 DICARBONITRILE; 4 OXO 3,7 DIPHENYL 4,5 DIHYDRO 1 THIA 5,8A DIAZA[AS]INDACENE 2,6,8 DICARBONITRILE; 4 OXO 3,7 DIPHENYL 4,5 DIHYDRO 1 THIA 5,8A DIAZA[AS]INDACENE 6,8 DICARBONITRILE; 5 AMINO 1 (4 CHLOROPHENYL) 3 PHENYL 1H PYRROLE 2,4 DICARBONITRILE; 5 AMINO 1 (4 METHOXYPHENYL) 3 PHENYL 1H PYRROLE 2,4 DICARBONITRILE; 5 AMINO 1,3 DIPHENYL 1H PYRROLE 2,4 DICARBONITRILE; 5 AMINO 3 PHENYL 1 (4 TOLYL) 1H PYRROLE 2,4 DICARBONITRILE; 5 IMINO 2 PHENYL 4,5 DIHYDROPYRROLO[1,2 A]QUINAZOLIN 1,3 DICARBONITRILE; 5 OXO 2 PHENYL 4,5 DIHYDROPYRROLO[1,2 A]QUINAZOLIN 1,3 DICARBONITRILE; ALKENE DERIVATIVE; AROMATIC AMINE; HYDROBROMIC ACID; PYRROLE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; ELIMINATION REACTION; SUBSTITUTION REACTION;

EID: 30944435620     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397910500330213     Document Type: Article

References (13)

1. Abdelrazek, F. M. Heterocyclic synthesis with nitriles: Synthesis of some new thiophene and thieno[2,3-d]pyrimidine derivatives IV. Phosphorous, Sulfur Silicon Relat. Elem. 1996, 119, 271-277.
2. Metwally, N. H.; Abdelrazek, F. M. Heterocyclic synthesis with nitriles: Synthesis of some novel pyrrolo[2,1-b]thiadiazoline, pyrrolo[2,1-b] thiadiazolo[3,2-a]pyrimidine and pyridine derivatives. J. Prakt. Chem. Chem. Zeitung 1998, 340, 676-678.
3. Abdelrazek, F. M.; Salah-Eldin, A. M.; Mekky, A. E. The reaction of ethyl benzoyl-acetate with malononitrile: A novel synthesis of some pyridazine, pyridazino[2,3-a]quinazoline and pyrrole derivatives. Tetrahedron 2001, 57, 1813-1817.
4. Abdelrazek, F. M.; Metz, P.; Farrag, E. K. Synthesis and molluscicidal activity of 5-oxo-5,6,7,8-tetrahydro-4H-chromene derivatives. Arch. Pharm. Pharm. Med. Chem. (Weinheim) 2004, 337 (9), 482-485.
5. 3, ketones, and alkylhydrazines. J. Chem. Soc. Chem. Commun. 1987, 788-789.
6. Toja, E.; Depaoli, A.; Tuan, G.; Kettenring, J. Synthesis of 2-amino-3-ethoxy-carbonylpyrroles. Synthesis 1987, 272-274.
7. Abdelrazek, F. M. Some reactions with ω-bromoacetophenone: Synthesis of new-pyrazole, pyrrole and furan derivatives. J. Prakt. Chem. 1990, 332(4), 479-483.
8. Gewald, K.; Schaefer, H.; Bellmann, P.; Hain, U. On the synthesis of 3-aminopyrroles by Thorpe-Ziegler cyclization. J. Prakt. Chem. 1992, 334(4), 491-496.
9. Süsse, M.; Johne, S. A synthesis of pyrrolo[1,2-a]quinazoline, indolo[1,2-a]quinazolinones, pyrrolo[1,2-a]thieno[3,2-e]pyrimidinones, benzothieno[3,2-e]pyrrolo[1,2-a]pyrimidinones and 6H-cyclohepta[4,5]thieno[3,2- e]pyrrolo[1,2-a]pyrimidinones. J. Prakt. Chem. 1981, 323 (4), 647-658.
10. α,β- butenolide and its transformation into pyrrole derivatives. Heteroatom Chem. 1995, 6 (1), 77-80.
11. Hilmy, K. M. H.; Pedersen, E. B. Nitriles in heterocyclic synthesis: A novel synthesis of 2-amino-3-pyrrolecarbonitriles. Liebigs Ann. Chem. 1989, 1145-1146.
12. Abdelrazek, F. M.; Bahbouh, M. S. Heterocyclic synthesis with nitriles: Synthesis of some novel pyrrole, pyrrolo[1,2-a]quinazoline and pyrrolo[1,2-a]triazine derivatives. Phosphorous, Sulfur Silicon Relat. Elem. 1996, 116, 235-241 and references therein.
13. Abdelrazek, F. M. Heterocyclic synthesis with nitriles: Synthesis of some new thiophene, pyridazine, oxazine, thiopyran, pyrrole and pyrrolo[1,2-b] pyridazine derivatives. Synth. Commun. 2005, 35 (17).