Experience with levamisole in frequently relapsing, steroid-dependent nephrotic syndrome

Pediatric Nephrology

Volumn 21, Issue 2, 2006, Pages 201-205

  Al Saran, K ^a   Mirza, K ^a   Al Ghanam, G ^a   Abdelkarim, M ^a  

^a Riyadh Medical Complex   (Saudi Arabia)

Author keywords

Corticosteroids; Levamisole; Nephrotic syndrome; Steroid dependent

Indexed keywords

CORTICOSTEROID DERIVATIVE; IMMUNOMODULATING AGENT; LEVAMISOLE; PREDNISOLONE;

AGE DISTRIBUTION; ARTICLE; BODY WEIGHT; BONE MARROW SUPPRESSION; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG COST; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; EXPERIENCE; FEMALE; FOLLOW UP; HUMAN; IDIOPATHIC DISEASE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; NEPHROTIC SYNDROME; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENCE RISK; SEX RATIO; STATISTICAL SIGNIFICANCE; TREATMENT FAILURE;

ADJUVANTS, IMMUNOLOGIC; CHILD, PRESCHOOL; FEMALE; GLUCOCORTICOIDS; HUMANS; LEVAMISOLE; MALE; NEPHROTIC SYNDROME; PREDNISOLONE; PROSPECTIVE STUDIES; RECURRENCE;

EID: 30944434731     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-005-2080-9     Document Type: Article

References (24)

1. McEnery P.T. Strife C.E. (1982) Nephrotic syndrome in childhood. anagement and treatment in patients with minimal change, mesangial proliferation or focal glomerulosclerosis. Pediatr Clin North Am 29:875894 7050865
2. ISKDC (1978) The primary nephrotic syndrome in children: Prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. A report of the International Study of Kidney disease in children. Kidney Int 13:159-165 713276
3. Niaudet P (2004) Steroid-sensitive nephrotic syndrome in children. In: Avner ED, Harmon WE, Niaudet P (eds) Pediatric nephrology. Lippincott Williams and Wilkins, Philadelphia, pp 543-556
4. Koskimies O, Vilska J, Rapola J Hallman N (1987) Long-term outcome of primary nephrotic syndrome. Arch Dis Child 57:544-548
5. Szeto CC, Gillespie KM, Mathieeson PW (2000) Levamisole induces interleukin 18 and shifts THI/TH2 balance. Immunology 100:217-222 10.1046/j.1365-2567.2000.00042.x
6. Tanphaichitr P, Tanphaichitr D, Sureeratanan J (1980) Treatment of nephrotic syndrome with levamisole. J Ped 96:490-493
7. British Association for Pediatric Nephrology (1991) Levamisole for corticosteroid dependent nephrotic syndrome in childhood. Lancet 337:1555-1557 675705
8. Dayal U, Dayal AK, Shastry JC, Raghupathy P (1994). Use of levamisole in maintaining remission in steroid sensitive nephrotic syndrome in children. Nephron 66:408-412 8015643
9. Rashid HU, Ahmed S, Fatima N, Khanam A (1996) Levamisole in the treatment of steroid dependent or frequent relapsing nephrotic syndrome in children. Bangladesh Ren J 15:6-8
10. Al-Saran K, Grisaru S, Stephens D, Arbus G (2001) Levamisole vs. cyclophosphamide for frequently relapsing steroid-dependent nephrotic syndrome. Clin Nephrol 56:289-294 11680658
11. Niaudet P, Drachman R, Gangnadoux MF, Broyer M (1994) Treatment of idiopathic nephrotic syndrome with levamisole. Acta Pediatr Scand 73:637-641
12. Meregalli P, Bianchetti MG, Imoberdorf FG, Lutschg J, Reymond D, Oetliker OH (1994) Levamisole in children with frequently recurring idiopathic nephrotic syndrome. Schweiz Med Wochen Schr 124:801-805
13. Ksiazek J, Krynski J (2000) Evaluation of the efficacy of levamisole in corticosteroid-dependent nephrotic syndrome in children. Pediatr Taiwan 41:80-84
14. Bagga A, Sharma A, Srivastava RN (1998) Levamisole therapy in corticosteroid dependent nephrotic syndrome in children. Pediatr Nephrol 11:415-447 10.1007/s004670050307
15. Kemper MJ, Amon O, TimmerMann K, Aldrogge H, Muller Wiefel DE (1998) The treatment with levamisole of frequently recurring steroid sensitive idiopathic nephrotic syndrome in children. Dtsch Med Wochenschr 123:239-243 9524533
16. Fu LS, Chi CS (2000) Levamisole in steroid-sensitive nephrotic syndrome children with steroid dependency and/or frequent relapses. Acta Pediatr Taiwan 41:80-84
17. Drachman R, Schlesinger M, Alon U, Mor J, Etzioni A, Shapira H, Ohali M, Drukker A (1988) Immunoregulation with levamisole in children with frequently relapsing steroid responsive nephrotic syndrome. Acta Paediatr Scand 7:721-726
18. Alshaya HO, Kari JA (2002) Levamisole treatment in steroid-sensitive nephrotic syndrome. Saudi Med J. 23:1001-1104
19. Donia AF, Amer GM, Ahmed HA, Gazareen SH, Moustafa FE, Shoeib AA, Ismail AM, Khamis S, Sobh MA (2002) Levamisole: Adjunctive therapy in steroid-dependent minimal change nephrotic children. Pediatr Nephrol 17:355-358 10.1007/s00467-001-0813-y
20. Barbano G, Ginevri F, Ghiggeri GM, Gusmano R (1999) Disseminated autoimmune disease during levamisole treatment of nephrotic syndrome. Pediatr Nephrol 13:602-603 10.1007/s004670050753
21. Bulugahapitiya DT (1997) Liver toxicity in a nephrotic patient treated with levamisole. Arch Dis Child 76:289
22. Palcoux JB, Niaudet P, Goumy P (1994) Side effects of levamisole in children with nephrosis. Pediatr Nephrol 8:263-264 10.1007/BF00865500
23. Arbeitsgemeinschaft für Pädiatrische Nephrologie (1979) Alternate-day vs. intermittent prednisolone in frequently relapsing nephrotic syndrome. Lancet i:401-403
24. Durkan A, Hodson E, Willis N, Craig J (2001) Non-corticosteroid treatment for nephrotic syndrome in children. Kidney Int 59:1919-1926 10.1046/j.1523-1755.2001.0590051919.x