Effects of indinavir in a preliminary phase I study on dogs with stage III slenic hemangiosarcoma

In Vivo

Volumn 20, Issue 1, 2006, Pages 125-128

  Spugnini, Enrico P ^a   Esposito, Vincenzo ^b,c   Groeger, Angela M ^c,d   Cassandro, Roberto ^b   Onori, Nicoletta ^e   Chirianni, Antonio ^b   Baldi, Alfonso ^a,f  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b AO Dei Colli Hospital for Infectious Diseases D Cotugno   (Italy)

^c International Society for the Study of Comparative Oncology ISSCO   (United States)

^d UNIVERSITY OF VIENNA   (Austria)

^e UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^f SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Dog; Hemagiosarcoma; Indinavir

Indexed keywords

INDINAVIR; PROTEINASE INHIBITOR;

ADVANCED CANCER; ANGIOSARCOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD TOXICITY; CANCER STAGING; CLINICAL STUDY; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; DOG DISEASE; DRUG EFFICACY; DRUG POTENCY; GASTROINTESTINAL TOXICITY; HEMOPERITONEUM; MICROSCOPY; MINIMAL RESIDUAL DISEASE; NONHUMAN; SPLEEN TUMOR;

EID: 30844449218     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Carpenter CC, Cooper DA and Fischl MA: Antiretroviral therapy in adults: updated recommendations of the International AIDS society-USA Panel. JAMA 283: 381-390, 2000.
2. Aversa SM, Cattelan AM, Salvagno L, Crivellari G, Banna G, Trevenzoli M, Chiarion-Sileni V and Monfardini S: Treatments of AIDS-related Kaposi's sarcoma. Crit Rev Oncol Hematol 53: 253-265, 2005.
3. Lebbe C, Blum L, Pellet C, Blanchard G, Verola O, Morel P, Danne O and Calvo F: Clinical and biological impact of antiretroviral therapy with protease inhibitors on HIV-related Kaposi's sarcoma. AIDS 2: F45-F49, 1998.
4. Cattelan AM, Calabro ML, Aversa SM, Zanchetta M, Meneghetti F, De Rossi A and Chieco-Bianchi L: Regression of AIDS-related Kaposi's sarcoma following antiretroviral therapy with protease inhibitors: biological correlates of clinical outcome. Eur J Cancer 35: 1809-1815, 1999.
5. Sgadari C, Barillari G, Toschi E, Carlei D, Bacigalupo I, Baccarini S, Palladino C, Leone P, Bagarini R, Malavasi L, CAfaro A, Falchi M, Valdembri D, Rezza G, Bussolino F, Monini P and Ensoli B: HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma. Nature Med 8: 225-232, 2002.
6. Hanahan D and Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364, 1996.
7. Singh RK, Bucana CD, Gutman M, Fan D, Wilson MR and Fidler IJ: Organ site-dependent expression of basic fibroblast growth factor in human renal cell carcinoma. Am J Pathol 145: 365-374, 1994.
8. Fosmire SP, Dickerson EB, Scott AM, Bianco SR, Pettengill MJ, Meylemans H, Padilla M, Frazer-Abel AA, Akhtar N, Getzy DM, Wojcieszyn J, Breen M, Helfand SC and Modiano JF: Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium. Lab Invest 84: 562-572, 2004.
9. Clifford CA, Hughes D, Beal MW, Mackin AJ, Henry CJ, Shofer FS and Sorenmo KU: Plasma vascular endothelial growth factor concentrations in healthy dogs and dogs with hemangiosarcoma. J Vet Intern Med 15: 131-135, 2001.
10. Prymac C, McKee L, Goldschmidt MH and Glickman LT: Epidemiologic, clinical, pathologic, and prognostic characteristics of splenic hemangiosarcoma and splenic hematoma in dogs: 217 cases. J Am Vet Med Assoc 193: 706-712, 1988.
11. Sprangler WL and Kass PH: Pathologic factors affecting postsplenectomy survival in dogs. J Vet Intern Med 11: 166-171, 1997.
12. Clifford CA, Hughes D, Beal MW, Mackin AJ, Henry CJ, Shoer FS and Soremno KU: Plasma vascular endothelial growth factor concentrations in healthy dogs and dogs with hemangiosarcoma. J Vet Intern Med 15: 131-135, 2001.
13. Racoosin JA and Kessler CM: Bleeding episodes in HIV-positive patients taking HIV protease inhibitors: a case series. Haemophilia 5: 266-269, 1999.
14. Wilde JT: Protease inhibitor therapy and bleeding. Haemophilia 6: 487-490, 2000.
15. Soremno KU, Jeglum KA and Helfand SC: Chemotherapy of canine hemangiosarcoma with doxorubicin and cyclophosphamide. J Vet Intern Med 7: 370-376, 1993.
16. Soremno KU, Baez JL, Clifford CA, Mauldin E, Overley B, Skorupski K, Bacham R, Samluk M and Shofer F: Efficacy and toxicity of a dose-intensified doxorubicin protocol in canine hemangiosarcoma. J Vet Intern Med 18: 209-213, 2004.