Assay of clozapine and risperidone in commercial tablets by high performance liquid chromatography

Chinese Pharmaceutical Journal

Volumn 53, Issue 6, 2001, Pages 303-312

  Shen, Yi Ling ^a   Wu, Shou Mei ^a   Wu, Hsin Lung ^a   Ko, Wei Kung ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b Tsyr Huey Mental Hospital   (Taiwan)

Author keywords

Clozapine; HPLC UV; Risperidone; Tablet

Indexed keywords

EID: 30844442584     PISSN: 10161015     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Jann, M. W.; Grimsley, S. R.; Gray, E. C.; Chang, W. H. Pharmacokinetics and Pharmacodynamics of Clozapine. Clin. Pharmacokinet. 1993, 24, 161-176.
2. Daniel, D. G.; Whitcomb, S. R. Treatment of the Refractory Schizophrenic Patient. J. Clin. Psychiatry 1998, 59(suppl 1), 13-19.
3. Fitton, A.; Heel, R. C. Clozapine: A Review of Its Pharmacological Properties and Therapeutic Use in Schizophrenia. Drugs 1990, 40, 722-747.
4. Kane, J. M.; Honigfeld, G.; Singer, J.; Meltzer, H. Y. Clozaril Study Group. Clozapine for the Treatment-resistant Schizophrenic. Arch Gen. Psychiatry 1988, 45, 789-796.
5. Grant, S.; Fitton, A. Risperidone, a Review of Its Pharmacology and Therapeutic Potential in the Treatment of Schizophrenia. Drugs 1994, 48, 253-273.
6. National Disease Therapeutic Index (NDTI) (1997): International Medical Statistics (IMS) America Full year 1997 data.
7. Lovdahl, M. J.; Perry, P. J.; Miller, D. D. The Assay of Clozapine and N-Desmethylclozapine in Human Plasma by High-performance Liquid Chromatography. Ther. Drug Monit. 1991, 13(1), 69-72.
8. Weigmann, H.; Hiemke, C. Determination of Clozapine and Its Major Metabolites in Human Serum Using Automated Solid-phase Extraction and Subsequent Isocratic High-performance Liquid Chromatography with Ultraviolet Detection. J. Chromatogr. B 1992, 583, 209-216.
9. Olesen, O. V.; Poulsen, B. On-line Fully Automated Determination of Clozapine and Desmethylclozapine in Human Serum by Solid-phase Extraction on Exchangeable Cartridges and Liquid Chromatography Using a Methanol Buffer Mobile Phase on Unmodified Silica. J. Chromatogr. B 1993, 622, 39-46.
10. Balant-Gorgia, A. E.; Gex-Fabry, M.; Genet, C.; Balant, L. P. Therapeutic Drug Monitoring of Risperidone Using a New Rapid HPLC Method: Reappraisal of Interindividual Variability Factors. Ther. Drug Monit. 1999, 27, 105-115.
11. Chung, M. C.; Lin, S. K.; Chang, W. H.; Jann, M. W. Determination of Clozapine and Desmethylclozapine in Human Plasma by High Performance Liquid Chromatography with Ultravioletr Detection. J. Chromatogr. B 1993, 613, 168-173.
12. Gupta, R. N. Column Liquid Chromatographic Determination of Clozapine and N-Desmethylclozapine in Human Serum Using Solid-phase Extraction. J. Chromatogr. B 1995, 673, 311-315.
13. Freeman, D. J.; Li, M. C.; Oyewumi, K. Solid-phase Extraction and High-performance Liquid Chromatographic Analysis of Clozapine and Norclozapine in Human Plasma. Ther. Drug Monit. 1996, 18(6), 688-692.
14. Endo, L.; Combourieu, I.; Cazenave, M.; Tignol, J. Assay for Quantisation of Clozapine and Its Metabolite N-Desmethylclozapine in Human Plasma by High-performance Liquid Chromatography with Ultraviolet Detection. J. Pharm. Biomed. Anal. 1997, 16(6), 311-318.
15. Akerman, K. K. Analysis of Clozapine and Norclozapine by High-performance Liquid Chromatogrphy. J. Chromatogr. B 1997, 696, 253-259.
16. Avenoso, A.; Facciola, G.; Campo, G. M.; Fazio, A.; Spina, E. Determination of Clozapine, Desmethylclozapine and Clozapine N-Oxide in Human Plasma by Reversed-phase High-performance Liquid Chromatography with Ultraviolet Detection. J. Chromatogr. B 1998, 714, 299-308.
17. Coudore, F.; Nicolay, A.; Hoareau, M.; Eschalier, A. Another Use of Silica Gel and Aqueous Eluent for HPLC Analysis of Clozapine and Desmethylclozapine. J. Anal. Toxicol. 1999, 23, 195-199.
18. Hariharan, U.; Hariharan M.; Naickar, J. S.; Tandon R. Determination of Clozapine and Its Two Major Metabolites in Human Serum by Liquid Chromatography Using Ultraviolet Detection. J. Liq. Chrom. & Rel. Technol. 1996, 19, 2409-2417.
19. Raggi, M. A.; Bugamelli, F.; Mandrioli, R.; De Ronchi, D.; Volterra, V. Development and Validation of an HPLC Method for the Simultaneous Determination of Clozapine and Desmethylclozapine in Plasma of Schizophrenic Patients. Chromatographia, 1999, 49, 75-80.
20. Raggi, M. A.; Bugamelli, F.; Sabbioni, C.; De Ronchi, D.; Pinzauti, S.; Volterra, V. An Improved HPLC-ED Method for Monitoring Plasma Levels of Clozapine and Its Active Metabolites in Schizophrenic Patients. Chromatographia, 2000, 51, 147-153.
21. Markowitz, J. S.; Patrick, K. S. Thermal Degradation of Clozapine-N-oxide to Clozapine During Gas Chromatographic Analysis. J. chromatogr. B 1995, 668, 171-174.
22. Pucci, V.; Raggi, M.; Kenndler, E. Separation of Antipsychotic Drugs (clozapine, loxapine) and Their Metabolites by Capillary Zone Electrophoresis. J. Chromatogr. A 1999, 853, 461-468.
23. Pucci, V.; Raggi, M.; Kenndler, E. Separation of Eleven Central Nervous System Drugs by Capillary Zone Electrophoresis. J. Chromatogr. B 1999, 728, 263-271.
24. Raggi, M. A.; Bugamelli, F.; Mandrioli, R.; Sabbioni, C.; Volterra, V.; Fanali, S. Rapid Capillary Electrophoretic Method for the Determination of Clozapine and Desmethylclozapine in Human Plasma. J. Chromatogr. A 2001, 916, 289-296.
25. Woestenborghs, R.; Lorreyne, W.; Rompaey, F. V.; Heykants, J. Determination of Risperidone and 9-Hydroxyrisperidone in Plasma, Urine and Animal Tissues by High-performance Liquid Chromatography. J. Chromatogr. B 1992, 583, 223-230.
26. Aravagiri, M.; Marder, S. R.; Putten, T. V.; Midha, K. K. Determination of Risperidone in Plasma by High-performance Liquid Chromatography with Electrochemical Detection: Application to Therapeutic Drug Monitoring in Schizophrenic Patients. J. Pharm. Sci. 1993, 82(5), 447-449.
27. Le Moing, J. P.; Edouard, S.; Levron, J. C. Determination of Risperidone and 9-Hydroxyrisperidone in Human Plasma by High-performance Liquid Chromatography with Electrochemical Detection. J. Chromatogr. B 1993, 614, 333-339.
28. Price, M. C.; Hoffman, D. W. Therapeutic Drug Monitoring of Risperidone and 9-Hydroxyrisperidone in Serum with Solid-phase Extraction and High-performance Liquid Chromatography. Ther. Drug Monit. 1997, 19(3), 333-337.
29. Aravagiri, M. M.; Marder, S. R. Simultaneous Determination of Risperidone and 9-Hydroxyrisperidone in Plasma by Liquid Chromatography/electrospray Tandem Mass Spectrometry. J. Mass Spectrom. 2000, 35, 718-724.
30. Avenoso, A.; Facciola, G.; Salemi, M.; Spina, E. Determination of Risperidone and Its Major Metabolite 9-Hydroxyrisperidone in Human Plasma by Reversed-phase Liquid Chromatography with Ultraviolet Detection. J. Chromatogr. B 2000, 746, 173-181.
31. Kracmar, J.; Kracmarova, J.; Remsova, M.; Bokovikova, T. N.; Ciciro, V. E.; Nesterova, G. A.; Suranova, A. V.; Trius, N. V. UV-spectrophotometry in Drug Control. Pharmazie 1990, 45, 411-413.
32. Raggi, M. A.; Bugamelli, F.; Casamenti, G.; Giovanninetti, G.; Volterra, V. Quality Control of Pharmaceutical Preparations Containing Clozapine by Means of HPLC and Derivative UV Spectrophotometry. Pharmazie 1998, 53, 452-455.
33. Raggi, M. A.; Pucci, V.; Bugamelli, F.; Volterra, V. Comparison of Three Analytical Methods for Quality Control of Clozapine Tablets. J. AOAC International. 2001, 84, 361-366.
34. Pucci, V.; Raggi, M. A.; Kenndler, E. Quality Control of Pharmaceutical Formulations of Neuroleptic Drugs by Capillary Zone Electrophoresis. J. Liq. Chrom. & Rel. Technol. 2000, 23, 25-34.
35. United States Pharmacopoeia XXIII (1995).
36. The Japanese Pharmacopoeia XIII (1996).
37. British Pharmacopoeia (1999) p. 400.