Early changes in biochemical markers of bone turnover predict bone mineral density response to antiresorptive therapy in Korean postmenopausal women with osteoporosis

Endocrine Journal

Volumn 52, Issue 6, 2005, Pages 667-674

  Kim, Sang Wan ^a,b   Park, Do Joon ^a,b   Park, Kyong Soo ^a,c   Kim, Seong Yeon ^a,c   Cho, Bo Youn ^a,c   Lee, Hong Kyu ^a,c   Shin, Chan Soo ^a,c  

^a Seoul National University   (South Korea)

^b Seoul National University Biomedical Research Institute   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

Author keywords

Bone mineral density; Bone turnover marker; Logistic regression; Responders

Indexed keywords

ALENDRONIC ACID; AMINO TERMINAL TELOPEPTIDE; CONJUGATED ESTROGEN; MEDROXYPROGESTERONE ACETATE; OSTEOCALCIN;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE MINERAL; BONE TURNOVER; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; DRUG RESPONSE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; POSTMENOPAUSE OSTEOPOROSIS; PREDICTION; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION;

ADULT; AGED; AGED, 80 AND OVER; ALENDRONATE; BIOLOGICAL MARKERS; BONE AND BONES; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; COLLAGEN; COLLAGEN TYPE I; DENSITOMETRY, X-RAY; ESTROGENS; FEMALE; FEMUR NECK; HUMANS; KOREA; LONGITUDINAL STUDIES; MEDROXYPROGESTERONE; MIDDLE AGED; OSTEOCALCIN; OSTEOPOROSIS, POSTMENOPAUSAL; PEPTIDES; SPINE; TIME FACTORS;

EID: 30844440985     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.52.667     Document Type: Article

References (23)

1. Reginster JY, Deroisy R, Collette J, Albert A, Zegels B (1997) Prediction of bone loss rate in healthy postmenopausal women. Calcif Tissue Int 60: 261-264.
2. Garnero P, Sornay-Rendu E, Duboeuf F, Delmas PD (1999) Markers of bone turnover predict postmenopausal forearm bone loss over 4 years: the OFELY study. J Bone Miner Res 14: 1614-1621.
3. Rogers A, Hannon RA, Eastell R (2000) Biochemical markers as predictors of rates of bone loss after menopause. J Bone Miner Res 15: 1398-1404.
4. Garnero P, Sornay-Rendu E, Chapuy MC, Delmas PD (1996) Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res 11: 337-349.
5. Garnero P, Dargent-Molina P, Hans D, Schott AM, Breart G, Meunier PJ, Delmas PD (1998) Do markers of bone resorption add to bone mineral density and ultrasonographic heel measurement for the prediction of hip fracture in elderly women? The EPIDOS prospective study. Osteoporos Int 8: 563-569.
6. Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, Genant HK, Palermo L, Scott J, Vogt TM (1993) Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet 341: 72-75.
7. Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Wahner HW, Riggs BL (1993) Long-term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res 8: 1227-1233.
8. Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM (1995) Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332: 767-773.
9. Rosen CJ, Chesnut CH 3rd, Mallinak NJ (1997) The predictive value of biochemical markers of bone turn-over for bone mineral density in early postmenopausal women treated with hormone replacement or calcium supplementation. J Clin Endocrinol Metab 82: 1904-1910.
10. Riis BJ, Overgaard K, Christiansen C (1995) Biochemical markers of bone turnover to monitor the bone response to postmenopausal hormone replacement therapy. Osteoporos Int 5: 276-280.
11. Hannon R, Blumsohn A, Naylor K, Eastell R (1998) Response of biochemical markers of bone turnover to hormone replacement therapy: impact of biological variability. J Bone Miner Res 13: 1124-1133.
12. Garnero P, Darte C, Delmas PD (1999) A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover. Bone 24: 603-609.
13. Chesnut CH 3rd, Bell NH, Clark GS, Drinkwater BL, English SC, Johnson CC Jr, Notelovitz M, Rosen C, Cain DF, Flessland KA, Mallinak NJ (1997) Hormone replacement therapy in postmenopausal women: urinary N-telopeptide of type I collagen monitors therapeutic effect and predicts response of bone mineral density. Am J Med 102: 29-37.
14. Civitelli R, Gonnelli S, Zacchei F, Bigazzi S, Vattimo A, Avioli LV, Gennari C (1988) Bone turnover in postmenopausal osteoporosis. Effect of calcitonin treatment. J Clin Invest 82: 1268-1274.
15. Greenspan SL, Parker RA, Ferguson L, Rosen HN, Maitland-Ramsey L, Karpf DB (1998) Early changes in biochemical markers of bone turnover predict the long-term response to alendronate therapy in representative elderly women: a randomized clinical trial. J Bone Miner Res 13: 1431-1438.
16. Garnero P, Shih WJ, Gineyts E, Karpf DB, Delmas PD (1994) Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab 79: 1693-1700.
17. Cooper C, Stakkestad JA, Radowicki S, Hardy P, Pilate C, Dain MP, Delmas PD (1999) Matrix delivery transdermal 17beta-estradiol for the prevention of bone loss in postmenopausal women. The International Study Group. Osteoporos Int 9: 358-366.
18. Chang SP, Kim DY, Kim SJ, Lee JE, Woo JT, Kim SW, Yang IM, Cho YW, Kim JW, Kim YS, Choi YK (1997) Distribution of urinary N-telopeptide level and its correlation with bone mineral density and other biochemical markers in Korean postmenopausal women. Korean J Bone Metab 4 (Suppl): 10.
19. Delmas PD, Christiansen C, Mann KG, Price PA (1990) Bone Gla protein (osteocalcin) assay standardization report. J Bone Miner Res 5: 5-11.
20. Gorai I, Hosoda K, Chaki O, Taguchi Y, Nakayama M, Yoh K, Yamaji T, Minaguchi H (1998) A heterogeneity in serum osteocalcin N-terminal fragments in Paget's disease: a comparison with other biochemical indices in pre- and postmenopause. Calcif Tissue Int 63: 459-465.
21. Cummings SR, Karpf DB, Harris F, Genant HK, Ensrud K, LaCroix AZ, Black DM (2002) Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs. Am J Med 112: 281-289.
22. Sarkar S, Mitlak BH, Wong M, Stock JL, Black DM, Harper KD (2002) Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. J Bone Miner Res 17: 1-10.
23. Delmas PD, Li Z, Cooper C (2004) Relationship between changes in bone mineral density and fracture risk reduction with antiresorptive drugs: some issues with meta-analyses. J Bone Miner Res 19: 330-337.