Prognostic biomarkers in renal cell carcinoma: Relevance of DNA ploidy in predicting disease-related survival

International Journal of Biological Markers

Volumn 20, Issue 4, 2005, Pages 249-256

  Pinto, António E ^a   Monteiro, P ^a   Silva, G ^b   Ayres, J V ^a   Soares, J ^a  

^a INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

^b INSTITUTO SUPERIOR TÉCNICO   (Portugal)

Author keywords

DNA ploidy; Ki 67 index; p53 expression; Prognosis; Renal cell carcinoma

Indexed keywords

DNA; KI 67 ANTIGEN; PARAFFIN; PROTEIN P53; TUMOR MARKER;

ADULT; AGED; ANEUPLOIDY; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIPLOIDY; FEMALE; FLOW CYTOMETRY; FROZEN SECTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; KAPLAN MEIER METHOD; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; MALE; NEPHRECTOMY; PLOIDY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN EXPRESSION; TUMOR VOLUME; UNIVARIATE ANALYSIS;

EID: 30844435275     PISSN: 03936155     EISSN: None     Source Type: Journal    
DOI: 10.1177/172460080502000408     Document Type: Article

References (39)

1. Vogelzang NJ, Stadler WM. Kidney cancer. Lancet 1998; 352: 1691-6.
2. Robson CJ, Churchill BM, Anderson W. The results of radical nephrectomy for renal cell carcinoma. J Urol 1969; 101: 297-301.
3. Skinner DG, Colvin RB, Vermillion CD, Pfister RC, Lead-better WF. Diagnosis and management of renal cell carcinoma. A clinical and pathologic study of 309 cases. Cancer 1971; 28: 1165-77.
4. Medeiros LJ, Gelb AB, Weiss LM. Renal cell carcinoma. Prognostic significance of morphologic parameters in 121 cases. Cancer 1988; 61: 1639-51.
5. Giberti C, Oneto F, Martorana G, Rovida S, Carmignani G. Radical nephrectomy for renal cell carcinoma: long-term results and prognostic factors on a series of 328 cases. Eur Urol 1997; 31: 40-8.
6. Furhman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982; 6: 655-63.
7. Green LK, Ayala AG, Ro JY, et al. Role of nuclear grading in stage I renal cell carcinoma. Urology 1989; 34: 310-5.
8. Gelb AB, Shibuya RB, Weiss LM, Medeiros LJ. Stage I renal cell carcinoma. A clinicopathologic study of 82 cases. Am J Surg Pathol 1993; 17: 275-86.
9. Hofmockel G, Tsatalpas P, Müller H, et al. Significance of conventional and new prognostic factors for locally confined renal cell carcinoma. Cancer 1995; 76: 296-306.
10. Shankey TV, Rabinovitch PS, Bagwell B, et al. Guidelines for implementation of clinical DNA cytometry. Cytometry 1993; 14: 472-7.
11. Jochum W, Schröder S, al-Taha R, et al. Prognostic significance of nuclear DNA content and proliferative activity in renal cell carcinomas: A clinicopathologic study of 58 patients using mitotic count, MIB-1 staining, and DNA cytophotometry. Cancer 1996; 77: 514-21.
12. Papadopoulos I, Weichert-Jacobsen K, Wacker HH, Sprenger E. Correlation between DNA ploidy, proliferation marker Ki-67 and early tumor progression in renal cell carcinoma. A prospective study. Eur Urol 1997; 31: 49-53.
13. Uhlman DL, Nguyen PL, Manivel JC, et al. Association of immuno-histochemical staining for p53 with metastatic progression and poor survival in patients with renal cell carcinoma. J Natl Cancer Inst 1994; 86: 1470-5.
14. Bot FJ, Godschalk JCJ, Krishnadath KK, van der Kwast THM, Bosman FT. Prognostic factors in renal-cell carcinoma: immunohistochemical detection of p53 protein versus clinico-pathological parameters. Int J Cancer 1994; 57: 634-7.
15. Eble JN, Sauter G, Epstein JI, Sesterhenn IA, eds. WHO classification of tumours: Pathology and genetics of tumours of the urinary system and male genital organs. Lyon: IARC Press, 2004.
16. Sobin LH, Wittekind C, eds. International Union Against Cancer (UICC) TNM Classification of Malignant Tumors (ed 5). New York: NY, Wiley, 1997.
17. Deitch AD, Law H, White RD. A stable propidium iodide staining procedure for flow cytometry. J Histochem Cytochem 1982; 168: 357-63.
18. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 1983; 31: 1333-5.
19. Dean PN, Jett JH. Mathematical analysis of DNA distributions derived from flow microfluorometry. J Cell Biol 1974; 60: 523-7.
20. Hsu SM, Raine L, Fanger H. The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase techniques. Am J Clin Pathol 1981; 75: 816-21.
21. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457-81.
22. Cox DR. Regression models and life-tables (with discussion). J Royal Stat Soc B 1972; 34: 187-220.
23. Grignon DJ, Ayala AG, el-Naggar AK, et al. Renal cell carcinoma. A clinicopathologic and DNA flow cytometric analysis of 103 cases. Cancer 1989; 64: 2133-40.
24. Abou-Rebyeh H, Borgmann V, Nagel R, Al-Abadi H. DNA ploidy is a valuable predictor for prognosis of patients with resected renal cell carcinoma. Cancer 2001; 92: 2280-5.
25. Silverio FD, Casale P, Colella D, Andrea L, Seccareccia F, Sciarra A. Independent value of tumor size and DNA ploidy for the prediction of disease progression in patients with organ-confined renal cell carcinoma. Cancer 2000; 88: 835-43.
26. Ljungberg B, Larsson P, Stenling R, Roos G. Flow cytometric deoxyribonucleic acid analysis in stage I renal cell carcinoma. J Urol 1991; 146: 697-9.
27. Gelb AB, Sudilovsky D, Wu CD, Weiss LM, Medeiros LJ. Appraisal of intratumoral microvessel density, MIB-1 score, DNA content, and p53 protein expression as prognostic indicators in patients with locally confined renal cell carcinoma. Cancer 1997; 80: 1768-75.
28. Lanigan DJ, McLean PA, Murphy DM, Donovan MG, Leader M. Image analysis in the determination of ploidy and prognosis in renal cell carcinoma. Eur Urol 1992; 22: 228-34.
29. Yu DS, Hsu CM, Lee WH, Chang SY, Ma CP. Flow cytometric DNA and cytomorphometric analysis in renal cell carcinoma: its correlation with histopathology and prognosis. J Surg Res 1993; 55: 480-5.
30. Tannapfel A, Hahn HA, Katalinic A, Fietkan RJ, Kühn R, Wittekind CW. Prognostic value of ploidy and proliferation markers in renal cell carcinoma. Cancer 1996; 77: 164-71.
31. Ljungberg B, Stenling R, Roos G. DNA content in renal cell carcinoma with reference to tumor heterogeneity. Cancer 1985; 56: 503-8.
32. Nakano E, Kondoh M, Okatani K, Seguchi T, Sugao H. Flow cytometric analysis of nuclear DNA content of renal cell carcinoma correlated with histologic and clinic features. Cancer 1993; 72: 1319-23.
33. Nowell PC. Mechanisms of tumor progression. Cancer Res 1986; 46: 2203-7.
34. Ruiz-Cerdá JL, Hernández M, Sempere A, O'Connor JE, Kimler BF, Jiménez-Cruz F. Intratumoral heterogeneity of DNA content in renal cell carcinoma and its prognostic significance. Cancer 1999; 86: 664-71.
35. Rioux-Leclercq N, Turlin B, Bansard J-Y, et al. Value of immunohistochemical Ki-67 and p53 determinations as predictive factors of outcome in renal cell carcinoma. Urology 2000; 55: 501-5.
36. Cheville JC, Zincke H, Lohse CM, et al. pT1 clear cell renal cell carcinoma: A study of the association between MIB-1 proliferative activity and pathologic features and cancer specific survival. Cancer 2002; 94: 2180-4.
37. Ljungberg B, Bozoky B, Kovacs G, et al. p53 expression in correlation to clinical outcome in patients with renal cell carcinoma. Scand J Urol Nephrol 2001; 35: 15-20.
38. Sorensen FB. Quantitative analysis of nuclear size for objective malignancy grading: a review with emphasis on new, unbiased stereologic methods. Lab Invest 1992; 66: 4-11.
39. Ruiz-Cerdá JL, Hernández M, Gomis F, et al. Value of deoxyribonucleic acid ploidy and nuclear morphometry for prediction of disease progression in renal cell carcinoma. J Urol 1996; 155: 459-65.