"No one asked the baby" - An ethical issue in placebo-controlled trials in pregnant smokers

Canadian Journal of Clinical Pharmacology

Volumn 12, Issue 2, 2005, Pages

  Selby, Peter ^a   Kapur, Bhushan M ^a   Hackman, Richard ^a   Koren, Gideon ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Consent; Ethics; Nicotine; Placebo controlled trial

Indexed keywords

COTININE; NICOTINE PATCH; XENOBIOTIC AGENT;

ADULT; ANAMNESIS; ARTICLE; BABY; CASE REPORT; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DEPENDENCE; ETHICS; FEMALE; HUMAN; INFORMED CONSENT; MEDICAL EXAMINATION; NICOTINE REPLACEMENT THERAPY; PREGNANCY; SMOKING;

EID: 30744455062     PISSN: 1198581X     EISSN: 17106222     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Dempsy D, Jacob P, Benowitz NL. Accelerated metabolism of nicotine and cotinine in pregnant smokers. J Pharmacol Exp Ther 2002; 301: 594-8.
2. Fuchs FD, Klag MJ, Whelton PK. The classics: a tribute to the fiftieth anniversary of the randomized clinical trial. J Clin Epidemiol 2000; 53:335-42.
3. Shapiro AK, Shapiro E. The placebo: is it much ado about nothing? In: Anne Harrington, editor. The placebo effect. Cambridge: Harvard University Press; 1997. p. 12-36.
4. Windsor R, Boyd N, Orleans T. A meta-evaluation of smoking cessation intervention research among pregnant women: Improving the science and art, Health Educ Res. 1998; 13(3), 419-438.
5. Fisher S, Greenberg RP. How sound is the double-blind design for evaluating psychotropic drugs? J Nerv Ment Dis 1993; 181:345-50.
6. Koren G: Ethics of drug research in pregnancy, infancy and childhood. In: G. Koren, editor. Textbook of Ethics in Pediatric Research, Malabar, Fla; Krieger; 1993. p. 171-81.